Abstract:Background and Objectives:The Caveolin (CAV1-3) family contains a unique class of membrane integral proteins with cytosolic termini. CAV1 or CAV3 are essential components of the caveolar core complex, a disc-shaped multimeric macromolecular scaffold, which interacts with membrane lipids and proteins. CAV3 was conceptualized as a muscle-specific and CAV1 alternative isoform. Finally, most CAV3 protein interactions were identified under non-endogenous conditions in heterologous overexpression systems. However, r… Show more
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