Proyecto dosis eritematosa mínima (DEM): en busca del consenso en la técnica del fototest

Pérez‐Ferriols, A.

doi:10.1016/j.ad.2013.04.004

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…When it comes to the methods of adjusting UV-B dose which should be administered, the most popular is defining "Minimal Erythema Dose" (MED). MED refers to the smallest UV-B dose which is capable of provoking minimal erythema on the patient's skin [17]. Skin phototype can play a role in determining UV-B dosage.…”

Section: Nb-uvbmentioning

confidence: 99%

Phototherapy in Atopic Dermatitis

Lesiak¹,

Ciążyńska²

2021

Atopic Dermatitis - Essential Issues

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Atopic dermatitis (AD) is an inflammatory, recurrent and chronic disease that occurs in 2–10% of the population. Therapy of AD could be divided into topical (corticosteroids, calcineurin inhibitors) and systemic (cyclosporine, methotrexate, azathioprine or biological treatment). Phototherapy is taken into consideration as a second-line treatment, when topical therapy is unsuccessful. We distinguish many types of phototherapy, e.g. narrowband UVB (311–313 nm), UVA-1 therapy (340–400 nm), UVA/B combination, UVA therapy plus 8-methoxypsoralens (PUVA), 308 nm excimer laser (EL) and blue light. Phototherapy is effective in many cases, whether in adults or in children. It should be remembered that during therapy possible side effects may occur. Among them the risk of carcinogenesis is the most severe.

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Section: Nb-uvbmentioning

confidence: 99%

Phototherapy in Atopic Dermatitis

Lesiak¹,

Ciążyńska²

2021

Atopic Dermatitis - Essential Issues

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“…The MED is usually assessed by eye in a semiquantitative way. The degree of erythema depends on human skin phototypes , and it is unreliable in darker skin types .…”

Section: Introductionmentioning

confidence: 99%

Photosensitivity of murine skin greatly depends on the genetic background: clinically relevant dose as a new measure to replace minimal erythema dose in mouse studies

Gyöngyösi

Lőrincz

Keszeg

et al. 2016

Experimental Dermatology

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Artificial UV irradiation of murine skin is a frequently used method for testing photosensitivity, study carcinogenesis and photoprotective effects of different compounds. However, doses of UV radiation and mouse strains used in experiments vary greatly. The genetic background of mice may influence the photosensitivity as melanin content, pigmentation and hair cycle parameters are dissimilar. Doses of UV are often expressed in relation to the minimal erythema dose (MED) that was not necessarily determined for the given strain. We set out to standardize the method of measuring photosensitivity in three commonly used mouse strains, C57BL/6N, Balb/c and SKH-1. We found that MED may not be determined for some strains as erythema development in mice with diverse genotypes differs greatly. We measured the oedema response in vivo and ex vivo by using OCT. Given the strain-specific variability of erythema, we introduced Clinically Relevant Dose (CRD) as a new term to replace MED in experiments, to describe the lowest dose that triggers a perceptible skin reaction in mice. Not only the CRD but the proportion of erythema and oedema were different in strains examined. C57BL/6N mice display skin reactions at the lowest UVB dose, while SKH-1 hairless mice show changes, mostly oedema, after higher doses of UVB. The cellular composition and skin thickness were examined by histopathology. IL-1beta and IL-6 levels in skin correlated with the increasing doses of UVB. Despite the variations in the degree of erythema and oedema, no major differences in cytokine expressions were seen among various strains of mice.

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Phototherapy in Atopic Dermatitis

Salvador

Pérez‐Ferriols

2017

Advances in Experimental Medicine and Biology

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Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. Currently management of AD includes avoidance of triggering factors, skin care aiming to compensate the skin barrier defects, anti-inflammatory therapy (mostly topical corticosteroids and topical calcineurin inhibitors). When these first-line approaches are unsuccessful, systemic treatment or phototherapy ought to be carried out as next line of defence. Current phototherapy modalities for AD include broadband UVB (290-320 nm), narrowband UVB (311-313 nm), UVA-1 therapy (340-400 nm), UVA therapy plus 8-methoxypsoralens (PUVA), 308 nm excimer laser (EL) and Full spectrum light (FSL).

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Proyecto dosis eritematosa mínima (DEM): en busca del consenso en la técnica del fototest

Cited by 6 publications

References 4 publications

Phototherapy in Atopic Dermatitis

Phototherapy in Atopic Dermatitis

Photosensitivity of murine skin greatly depends on the genetic background: clinically relevant dose as a new measure to replace minimal erythema dose in mouse studies

Phototherapy in Atopic Dermatitis

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