PRS58 Treatment Outcomes of New Smear Positive Pulmonary Tuberculosis Patients in North East Libya

Solliman, M.M.; Hassali, M.A.; Shafie, A.A.; Atif, Muhammad; Saleem, Fahad; Al-Haddad, Mahmoud S.; Hadidan, M.

doi:10.1016/j.jval.2011.08.1445

Cited by 6 publications

(12 citation statements)

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“…Studies showed that foreigners either prefer to be transferred to their countries or defaulted from the treatment due to the fear of compulsory expulsion by the immigration authorities [ 15 , 21 ]. Similar to the findings of our study, two African studies also reported low treatment success rate in TB patients [ 17 , 22 ]. Likewise, in recent years, TB treatment success rate (new smear positive PTB cases) in Japan, Hong Kong and Fiji was less than 70%.…”

Section: Discussionsupporting

confidence: 92%

“…In this study, defaulters were the second most common group of patients in the unsuccessful treatment outcome category. Our finding (8.93%) is somewhat comparable to the results of studies from Singapore (9%), Germany (10%), Cameron (20%) and Libya (28%) [ 4 , 17 , 22 , 27 ]. In contrast, American and Norwegian studies showed relatively lower defaulter rates among TB patients [ 15 , 28 ].…”

Section: Discussionsupporting

confidence: 88%

“…Pseudo R square values were reported to provide information about the percentage of variance explained by the model. A p-value of <0.05 was considered statistically significant [ 4 , 15 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

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Treatment outcome of new smear positive pulmonary tuberculosis patients in Penang, Malaysia

et al. 2014

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BackgroundAccording to the World Health Organization’s recent report, in Malaysia, tuberculosis (TB) treatment success rate for new smear positive pulmonary tuberculosis (PTB) patients is still below the global success target of 85%. In this study, we evaluated TB treatment outcome among new smear positive PTB patients, and identified the predictors of unsuccessful treatment outcome and longer duration of treatment (i.e., > 6 months).MethodsThe population in this study consisted of all new smear positive PTB patients who were diagnosed at the chest clinic of Penang General Hospital between March 2010 and February 2011. During the study period, a standardized data collection form was used to obtain socio-demographic, clinical and treatment related data of the patients from their medical charts and TB notification forms (Tuberculosis Information System; TBIS). These data sources were reviewed at the time of the diagnosis of the patients and then at the subsequent follow-up visits until their final treatment outcomes were available. The treatment outcomes of the patients were reported in line with six outcome categories recommended by World Health Organization. Multiple logistic regression analysis was used to find the independent risk factors for unsuccessful treatment outcome and longer treatment duration. Data were analyzed using the PASW (Predictive Analysis SoftWare, version 19.0. Armonk, NY: IBM Corp).ResultsAmong the 336 PTB patients (236 male and 100 female) notified during the study period, the treatment success rate was 67.26% (n = 226). Out of 110 patients in unsuccessful outcome category, 30 defaulted from the treatment, 59 died and 21 were transferred to other health care facilities. The mean duration of TB treatment was 8.19 (SD 1.65) months. In multiple logistic regression analysis, risk factors for unsuccessful treatment outcome were foreign nationality, male gender and being illiterate. Similarly, risk factors for mortality due to TB included high-grade sputum and presence of lung cavities at the start of treatment, being alcoholic and elderly. Likewise, concurrent diabetes, presence of lung cavities at the start of the treatment and being a smoker were the significant predictors of longer treatment duration.ConclusionOur findings indicated that the treatment success rate among the new smear positive PTB patients was less than the success target set by World Health Organization. The proportion of patients in the successful outcome category may be increased by closely monitoring the treatment progress of the patients with aforementioned high risk characteristics. Similarly, more aggressive follow-up of the treatment defaulters and transferred out patients could also improve the TB treatment success rate.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

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Treatment outcome of new smear positive pulmonary tuberculosis patients in Penang, Malaysia

et al. 2014

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“…In the current study the major reasons for the lower treatment success rate were firstly, higher loss to follow-up and secondly, the death rate. Studies from Libya and Ethiopia also documented consistent findings regarding loss to follow-up among smear positive PTB patients [ 14 , 18 ]. At the local level, patient loss to follow-up might also be compounded by the need to purchase medicines to alleviate the side effects of TB medicines in those who already have poor financial status.…”

Section: Main Textmentioning

confidence: 62%

Analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in Bahawalpur, Pakistan

Atif

Anwar

Fatima³

et al. 2018

BMC Res Notes

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ObjectiveMonitoring tuberculosis treatment outcomes and understanding the reasons for unsuccessful treatment are important indicators for evaluating the performance of the national tuberculosis control program. The aim of this study was to evaluate the treatment outcomes among pulmonary TB (PTB) patients and identify the predictors of unsuccessful treatment outcome.ResultsTreatment success rate of 67.8% among new and retreatment PTB patients and 69% in new smear positive PTB patients was observed. Close to 21% (20.9%) and 15.7% PTB and new smear positive PTB patients had loss to follow-up during treatment. Overall, older patients (AOR 1.02; 95% CI 1.01–1.0), smokers (AOR 1.65; 95% CI 1.02–2.67) and retreatment cases of TB (AOR 2.34; 95% CI 1.43–3.84) were at greater risk of having unsuccessful treatment outcomes. Moreover, sputum positivity at 2 months (AOR 13.78; 95% CI 5.09–37.26) was a significant predictor of poor treatment outcomes in new smear positive PTB patients. The treatment success rate among PTB patients was lower than the recommended 85% success rate. TB patients at higher risk of unsuccessful treatment outcomes should be provided with enhanced supervision and treatment monitoring to improve the success rate of TB management in Pakistan.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3473-8) contains supplementary material, which is available to authorized users.

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“…This was a retrospective record review [15][16][17] of EPTB patients registered at the study site from 2015 to 2017.…”

Section: Methodsmentioning

confidence: 99%

Treatment outcomes of extrapulmonary tuberculosis in Bahawalpur, Pakistan; a record review

Atif

Fatima²,

Ahmad

et al. 2020

J of Pharm Policy and Pract

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Background: There is limited published data form Pakistan on treatment success rate among extrapulmonary tuberculosis (EPTB) patients. The aim of this study was to assess clinical form, treatment outcomes, and identify the factors associated with unfavorable treatment outcome among EPTB patients. Methods: A retrospective study was conducted at the Chest Disease Unit of the Bahawal Victoria Hospital, Pakistan. Medical records of EPTB patients, registered at the study site from January 1, 2015 to September 30, 2017, were reviewed to obtain the data. Final treatment outcomes among EPTB patients were evaluated in accordance with the standard Word Health Organization (WHO) criteria. Multivariate binary logistic regression analysis was used to identify the factors associated with unfavorable treatment outcome. Results: A total of 651 EPTB patients were included in the study. Highest proportion of patients had pleural TB (n = 217, 33.3%). Out of the total 651 patients, 463 (71.1%) successfully completed the treatment. Among 177 (27.2%) patients with unfavorable treatment outcome, 10 (1.5%) died, while 165 (25.4%) lost to follow-up the treatment. Lymph node TB (AOR 0.65, 95% CI 0.422, 0.989) and meningeal TB (AOR 2.1, 95% CI 1.065, 4.144) were significantly associated with unfavorable treatment outcome. Conclusion: The treatment success (favorable outcome) rate among EPTB patients was less than the target (i.e., ≥ 90%) set by the WHO. Highest proportion of patients lost to follow-up during the treatment.

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PRS58 Treatment Outcomes of New Smear Positive Pulmonary Tuberculosis Patients in North East Libya

Cited by 6 publications

References 0 publications

Treatment outcome of new smear positive pulmonary tuberculosis patients in Penang, Malaysia

Treatment outcome of new smear positive pulmonary tuberculosis patients in Penang, Malaysia

Analysis of tuberculosis treatment outcomes among pulmonary tuberculosis patients in Bahawalpur, Pakistan

Treatment outcomes of extrapulmonary tuberculosis in Bahawalpur, Pakistan; a record review

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