Pru p 3 oral immunotherapy efficacy, induced immunological changes and quality of life improvement in patients with LTP syndrome

Pérez, Alejandra González; Martínez, Antonio Carbonell; Pastor, Ana; Garrido, C Navarro; López, Juan Carlos

doi:10.1186/s13601-020-00325-y

Cited by 7 publications

(13 citation statements)

References 5 publications

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“…In this study, the possibility of using Pru p 3 SLIT to treat patients suffering from LTP syndrome was confirmed, as also shown in other papers, with a positive impact on patients' quality of life as well [87,88]. Indeed, in the paper by González-Pérez et al, the authors showed that, in 18 adult patients treated for 3 consecutive years with Pru p 3 SLIT, the results on the Food Allergy Quality of Life Questionnaire-Adult Form (FAQLQ-AF) significantly decreased, showing a favorable impact on the patients' quality of life [87].…”

Section: Allergen Immunotherapysupporting

confidence: 85%

“…Furthermore, Beitia et al showed the effectiveness of Pru p 3 SLIT in a real-life study, including 29 patients, showing that, one year after starting SLIT, 73% had a negative challenge to peach, and, after 2 years, 95% of them did not react to the fruit [ 86 ]. In this study, the possibility of using Pru p 3 SLIT to treat patients suffering from LTP syndrome was confirmed, as also shown in other papers, with a positive impact on patients’ quality of life as well [ 87 , 88 ]. Indeed, in the paper by González-Pérez et al, the authors showed that, in 18 adult patients treated for 3 consecutive years with Pru p 3 SLIT, the results on the Food Allergy Quality of Life Questionnaire-Adult Form (FAQLQ-AF) significantly decreased, showing a favorable impact on the patients’ quality of life [ 87 ].…”

Section: Prevention and Managementsupporting

confidence: 84%

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Phenotypes and Endotypes of Peach Allergy: What Is New?

et al. 2022

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Peach allergy is emerging as a common type of fresh-fruit allergy in Europe, especially in the Mediterranean area. The clinical manifestations of peach allergy tend to have a peculiar geographical distribution and can range from mild oral symptoms to anaphylaxis, depending on the allergic sensitization profile. The peach allergen Pru p 7, also known as peamaclein, has recently been identified as a marker of peach allergy severity and as being responsible for peculiar clinical features in areas with high exposure to cypress pollen. This review addresses the latest findings on molecular allergens for the diagnosis of peach allergy, the clinical phenotypes and endotypes of peach allergy in adults and children, and management strategies, including immunotherapy, for peach allergy.

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Section: Allergen Immunotherapysupporting

confidence: 85%

Section: Prevention and Managementsupporting

confidence: 84%

Phenotypes and Endotypes of Peach Allergy: What Is New?

et al. 2022

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“…On the other hand, the LEAP study revealed that early food introduction can prevent the onset of allergy [ 14 ], the STOP study showed that induction of tolerance can halt allergy [ 15 ], and Pru p 3 SLIT induces an improvement not only in peach allergy but also acts upon other relevant food allergens causing severe reactions, such as peanut or tree nuts [ 16 , 17 , 18 ]. These facts could also have important implications for dietary recommendations for LTP-allergic patients.…”

Section: Introductionmentioning

confidence: 99%

LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later

et al. 2021

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Introduction: Allergy to nonspecific lipid transfer protein (nsLTP) is the main cause of plant-food allergy in Spain. nsLTPs are widely distributed in the plant kingdom and have high cross-reactivity but extremely variable clinical expression. Little is known about the natural evolution of this allergy, which complicates management. The objective of this study was to assess the development of allergy to new plant foods in nsLTP-sensitized patients 10 years after diagnosis. Methods: One hundred fifty-one patients showing specific IgE to nsLTP determined by ISAC (Thermofisher) were included. After clinical workup (i.e., anamnesis, skin test, and challenge when needed), these patients were divided into two groups: 113 patients allergic to one or more plant food (74.5%) and 38 patients not allergic to any plant food (25.1%). Ten years later, a telephone interview was conducted to check whether patients had developed additional allergic reactions to plant foods. Results: Ten years after diagnosis, 35 of the 113 (31%) plant-food-allergic patients sensitized to nsLTP reported reactions to new, previously tolerated plant foods, mainly Rosaceae/Prunoideae fruits and nuts followed by vegetables, Rosacea/Pomoideae fruits, legumes, and cereals. Five out of 38 (13.2%) patients previously sensitized to nsLTP but without allergy to any plant food had experienced allergic reactions to some plant food: two to Rosaceae/Prunoideae fruits, two to Rosaceae/Prunoideae fruit and nuts, and one to legumes. Conclusion: Patients sensitized to nsLTP developed allergic reactions to other plant foods, mainly Rosaceae-Prunoideae fruits and nuts. This was more frequent among plant-food-allergic patients than among those who had never had plant-food allergy.

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“…Except for one [ 19 ], all studies were performed in Spain. The majority of enrolled patients were young female and a frequent co-sensitization to pollens was present [ 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…Most studies adopted a protocol comprising build-up phase of several days, usually four, but rush and ultra-rush protocols, carried out in 2 and 1 day respectively, were also used [ 14 , 16 , 17 , 18 , 19 , 20 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

Immunotherapy with Pru p 3 for food allergy to peach and non-specific lipid transfer protein: a systematic review

et al. 2023

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Background Non-specific lipid-transfer protein (nsLTP) is a pan-allergen in the plant world, and a cause of significant concern as food allergen in the Mediterranean area, due to its general heat- and acid-resistance and hence the risk of severe allergic reactions. Pru p 3, the peach nsLTP, is considered the primary sensitizer to this allergen family and this allergy is usually persistent. Allergen-free diet and acute treatment of manifestations are the main recognized management goals in food allergy. Main text The role of immunotherapy for treating food allergy in adult patients is controversial, but immunotherapy for Pru p 3 could potentially represent a relevant therapeutic strategy. We systematically searched databases for studies assessing the role of immunotherapy Pru p 3 in food allergy. Overall, nine studies were included. Immunotherapy with Pru p 3 appears to be effective and with a good safety profile in both peach and LTP allergy for some foods, such as peanut, in both RCT and real-life studies. Conclusions Immunotherapy with Pru p 3 is a possible treatment option for food allergy to the peach LTP in the Mediterranean area, although at present have not reached routinary clinical practice. Larger studies are needed to confirm these findings and identify predictive biomarkers.

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Pru p 3 oral immunotherapy efficacy, induced immunological changes and quality of life improvement in patients with LTP syndrome

Cited by 7 publications

References 5 publications

Phenotypes and Endotypes of Peach Allergy: What Is New?

Phenotypes and Endotypes of Peach Allergy: What Is New?

LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later

Immunotherapy with Pru p 3 for food allergy to peach and non-specific lipid transfer protein: a systematic review

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