Prune homolog 2 with BCH domain (PRUNE2) gene expression is associated with feed efficiency-related traits in Nelore steers

Lima, A. O. de; Malheiros, Jessica Moraes; Afonso, Juliana; Petrini, Juliana; Coutinho, Luiz Lehmann; Diniz, Wellison J. S.; Bressani, Flavia A.; Tizioto, P. C.; Oliveira, P. S. N.; Ribeiro, Janssen Ayna Silva; Oliveira, Karina Santos de; Rocha, M. I. P.; Andrade, Bruno de Bezerril; Fukumasu, Heidge; Beiki, Hamid; Reecy, James M.; Zerlotini, Adhemar; Mourão, Gérson Barreto; Regitano, L. C. de A.

doi:10.1007/s00335-022-09960-1

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“…The genes GNA12 and AMZ1 on BTA25 were reported as important for carcass gain in Holsteins (Mao et al, 2016). AMZ1, BRAT1, and PRUNE2 affected residual feed intake and maintenance efficiency in Nelore cattle [51,52]. For example, BRAT1 regulates cell growth and apoptosis [53].…”

Section: Discussionmentioning

confidence: 99%

Genotype by Prenatal Environment Interaction for Postnatal Growth of Nelore Beef Cattle Raised under Tropical Grazing Conditions

Júnior

Bignardi

Pereira

et al. 2023

Animals

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The prenatal environment is recognized as crucial for the postnatal performance in cattle. In tropical regions, pregnant beef cows commonly experience nutritional restriction during the second half of the gestation period. Thus, the present study was designed to analyze the genotype by prenatal environment interaction (G × Epn) and to identify genomic regions associated with the level and response in growth and reproduction-related traits of beef cattle to changes in the prenatal environment. A reaction norm model was applied to data from two Nelore herds using the solutions of contemporary groups for birth weight as a descriptor variable of the gestational environment quality. A better gestational environment favored weights until weaning, scrotal circumference at yearling, and days to first calving of the offspring. The G × Epn was strong enough to result in heterogeneity of variance components and genetic parameters in addition to reranking of estimated breeding values and SNPs effects. Several genomic regions associated with the level of performance and specific responses of the animals to variations in the gestational environment were revealed, which harbor QTLs and can be exploited for selection purposes. Therefore, genetic evaluation models considering G × Epn and special management and nutrition care for pregnant cows are recommended.

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Section: Discussionmentioning

confidence: 99%