Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling

Guo, Qingling; Qu, Haili; Zhang, Hong; Zhong, Xia

doi:10.2147/dddt.s325814

Cited by 21 publications

(19 citation statements)

References 25 publications

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“…The thyroid volume, thyroiditis inflammation score and serum thyroglobulin antibody levels of EAT rats were attenuated by PV treatment. Mechanism studies manifested that PVL could attenuates EAT by inhibiting HMGB1/TLR9 Signaling ( Guo et al, 2021 ). For more information, Supplementary Table S4 .…”

Section: Pharmacologymentioning

confidence: 99%

Prunella vulgaris L. – A Review of its Ethnopharmacology, Phytochemistry, Quality Control and Pharmacological Effects

2022

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Prunella vulgaris L. (PVL) is dried fruit spike of Lamiacea plant Prunella vulgaris L., which is a perennial herb with medicinal and edible homology used for thousands of years. PVL is bitter, acrid, cold, and belongs to the liver and gallbladder meridians. It clears the liver and dissipate fire, improve vision, disperse swelling, and has satisfactory clinical therapeutic effects on many diseases such as photophobia, dizziness, scrofula, goiter, breast cancer. The collection of information and data related to PVL comes from literatures retrieved and collated from various online scientific databases (such as CNKI, VIP, PubMed, Web of Science, Research Gate, Science Database), ancient books of traditional chinese medicine (Encyclopedia of Traditional Chinese Medicine, Classics of Traditional Chinese Medicine, Dictionary of Traditional Chinese Medicine), and Doctoral and Master’s Dissertations. Currently, the major chemical constituents isolated and identified from PVL are triterpenoids, steroids, flavonoids, phenylpropanoids, organic acids, volatile oils and polysaccharides. Modern pharmacological studies have shown that PVL has a wide range of pharmacological activities, including anti-inflammatory, anti-tumor, antibacterial and antiviral effects, as well as immune regulation, antihypertensive, hypoglycemic, lipid-lowering, antioxidant, free radical scavenging, liver protection, sedative and hypnotic effects. This paper reviewes the botany, ethnopharmacology, traditional application, phytochemistry, analytical methods, quality control, pharmacological effects of PVL. It can be used not only as medicine, but also gradually integrated into the “medicine and food homology” and “Chinese medicine health” boom. More importantly, it has great potential for drug resources development. This paper deeply discusses the shortcomings of current PVL research, and proposes corresponding solutions, in order to find a breakthrough point for PVL research in the future. At the same time, it is necessary to further strengthen the research on its medicinal chemistry, mechanism of action and clinical application efficacy in the future, and strive to extract, purify and synthesize effective components with high efficiency and low toxicity, so as to improve the safety and rationality of clinical medication.

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Section: Pharmacologymentioning

confidence: 99%

Prunella vulgaris L. – A Review of its Ethnopharmacology, Phytochemistry, Quality Control and Pharmacological Effects

2022

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“…HMGB1/TLR9/MYD88 is also one of the pathways in the pathogenesis of HT. Activation of this pathway produces large amounts of inflammatory factors such as TNF-α, IL-6, and IL-1β, which cause impaired thyroid function and lead to organ damage [81] (Fig. 3).…”

Section: Cytokines and Signaling Pathwaysmentioning

confidence: 99%

Pathogenesis Markers of Hashimoto's Disease—A Mini Review

Jin¹,

Wang²,

Fan³

2022

Front. Biosci. (Landmark Ed)

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Hashimoto's thyroiditis (HT) is the most common autoimmune disease involving the thyroid gland. HT often clinically manifest as hypothyroidism due to the destruction of thyroid cells mediated by humoral and cellular immunity. The pathogenesis of HT is a complex process in which environmental factors, hereditary inclination, trace elements immune factors, cytokines, and DNA and miRNA all play an important role. Herein, we summarize the precision factors involved in the pathogenesis of HT and offer an update over the past 5 years to provide a theoretical basis for further investigation of the relevant targets for HT treatment.

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“…Meanwhile, Azam et al [ 43 ] found that myeloid differentiation primary response 88 (MyD88)- or non-MyD88-dependent signaling could be activated by HMGB1 to trigger downstream signals via activation of TLR4, which enhances the secretion of cytokines via the NF-κB pathway. In addition, HMGB1 has been associated with activation of the TLR9/MyD88 pathway and the release of proinflammatory cytokines in autoimmune thyroiditis [ 44 ]. Besides, the lack of HMGB1 leads to increased susceptibility to hepatocyte death through TLR9 in response to oxidative stress [ 22 ].…”

Section: Hmgb1 Structure and Receptorsmentioning

confidence: 99%

“…In liver injury, activated HSCs can express TLR2, TLR3, TLR4, and TLR9. The interaction between TLR4 and liver inflammation has been widely reported [ 42 , 43 , 44 ]. For instance, TLR4 promotes early alcohol-induced liver injury by responding to increasing levels of circulating endotoxins [ 89 ].…”

Section: Hmgb1 and Schistosome-induced Liver Damagementioning

confidence: 99%

From Inflammation to Fibrosis: Novel Insights into the Roles of High Mobility Group Protein Box 1 in Schistosome-Induced Liver Damage

et al. 2022

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Schistosomiasis is a chronic helminthic disease of both humans and animals and the second most prevalent parasitic disease after malaria. Through a complex migration process, schistosome eggs trapped in the liver can lead to the formation of granulomas and subsequent schistosome-induced liver damage, which results in high mortality and morbidity. Although praziquantel can eliminate mature worms and prevent egg deposition, effective drugs to reverse schistosome-induced liver damage are scarce. High mobility group box 1 (HMGB1) is a multifunctional cytokine contributing to liver injury, inflammation, and immune responses in schistosomiasis by binding to cell-surface Toll-like receptors and receptors for advanced glycation end products. HMGB1 is increased in the serum of patients with schistosomiasis and enables hepatic stellate cells to adopt a proliferative myofibroblast-like phenotype, which is crucial to schistosome-induced granuloma formation. Inhibition of HMGB1 was found to generate protective responses against fibrotic diseases in animal models. Clinically, HMGB1 presents a potential target for treatment of the chronic sequelae of schistosomiasis. Here, the pivotal role of HMGB1 in granuloma formation and schistosome-induced liver damage, as well the potential of HMGB1 as a therapeutic target, are discussed.

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Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling

Cited by 21 publications

References 25 publications

Prunella vulgaris L. – A Review of its Ethnopharmacology, Phytochemistry, Quality Control and Pharmacological Effects

Prunella vulgaris L. – A Review of its Ethnopharmacology, Phytochemistry, Quality Control and Pharmacological Effects

Pathogenesis Markers of Hashimoto's Disease—A Mini Review

From Inflammation to Fibrosis: Novel Insights into the Roles of High Mobility Group Protein Box 1 in Schistosome-Induced Liver Damage

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