Pruritic papular eruption of the acquired immunodeficiency syndrome: predominance of CD8<sup>+</sup> cells

Rosatelli, Jacy Berti; Soares, Fernando Augusto; Roselino, Ana Maria

doi:10.1046/j.1365-4362.2000.00914-2.x

Cited by 13 publications

(8 citation statements)

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“…The quantitative analysis of the Langerhans cells showed that these cells were part of the dermal inflammatory infiltrate, differing from other studies that have reported absence of S100 protein positive cells (Langerhans cells) in the dermal infiltrate (35) or an increased number of these cells in PPE‐HIV lesions (36). The morphological signs of endothelial cell activation disclosed by electron microscopy (characterized by increased numbers of transcellular channels and pseudopods) suggest a possible role for these cells in the genesis of the lesion.…”

Section: Discussioncontrasting

confidence: 91%

Pruritic Papular Eruption Associated with HIV‐Etiopathogenesis Evaluated by Clinical, Immunohistochemical, and Ultrastructural Analysis

Ramos

Pagliari

Takakura

et al. 2005

The Journal of Dermatology

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Pruritic Papular Eruption with Human Immunodeficiency Virus infection (PPE-HIV) is characterized by symmetrically distributed papules with pruritus in the skin of patients suffering advanced HIV infection. Although known since 1985, the etiology of this symptomatic dermatitis is unclear. We set out to characterize the phenotype of the infiltrating cells and the cytokine profile in the lesions, as an attempt to contribute to determining its etiopathogenesis. Clinical data and histological, immunohistochemical, and ultrastructural features of skin biopsies from 20 HIV patients with PPE were studied. The histopathological aspects, cell immunophenotypes, and cytokine expressions in the lesions where quantified and compared to perilesional skin, and to those in the clinically normal skin of HIV patients without PPE-HIV (n=11) and those in normal skin samples from HIV negative individuals (n=10). PPE-HIV occurred mainly in HIV patients with mean CD4+ counts of 124.6 +/- 104 lymphocytes/mm3. Furthermore, their eosinophil counts were significantly increased. The skin lesions were characterized by a predominantly perivascular dermal lymphohistiocytic inflammatory infiltrate. Langerhans cells were normally distributed in the epidermis and seen among the cellular components of dermal infiltrates. The density of CD8+ lymphocytes was elevated and the density of CD4+ cells was reduced in dermal infiltrates. Interleukin 5 was the predominant cytokine in the lesions. Electron microscopic analysis didn't disclose HIV or other infectious agents in the lesions. These results refute the hypothesis of an infectious etiology of PPE-HIV. CD8+ lymphocytes and Langerhans cells seem to have roles in the pathogenesis of PPE-HIV. The increased frequency of IL5 was associated with abundant eosinophils in the lesions, suggesting a type Th2 response in this dermatitis.

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Section: Discussioncontrasting

confidence: 91%

Pruritic Papular Eruption Associated with HIV‐Etiopathogenesis Evaluated by Clinical, Immunohistochemical, and Ultrastructural Analysis

Ramos

Pagliari

Takakura

et al. 2005

The Journal of Dermatology

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“…Mast cell inflammatory infiltration that has been described in both entities 24,25 was, in this study, significantly more intense in the HIV-EF group than in the HIV-PPE group, showing that it could also be useful for differentiating between these two manifestations. However, the eosinophil and mast cell infiltrates were not present in all cases of HIV-EF.…”

Section: Discussionsupporting

confidence: 62%

Pruritic papular eruption and eosinophilic folliculitis associated with human immunodeficiency virus (HIV) infection: A histopathological and immunohistochemical comparative study

Afonso

Tomimori

Michalany

et al. 2012

Journal of the American Academy of Dermatology

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“…The increased concentrations of serum IL‐2, IL‐12, and γ‐IFN, and of IL‐5, taken together with the decreased CD4 + T lymphocytes in peripheral blood and the predominance of CD8 + T cells in the infiltrate of lesioned skin, known to occur in PPE, 15 could explain the occurrence of a mixed pattern, Th1/Th2 or Th0, in which cytokines may be produced by CD8 + T lymphocytes, with a consequent large number of eosinophils in the cutaneous infiltrate of PPE, as well as eosinophilia and hyper‐IgE 6,15 …”

Section: Discussionmentioning

confidence: 99%

“…In PPE, increased CD8 + T lymphocytes, eosinophils, mast cells, and macrophages have been observed quantitatively by the immunoperoxidase technique in lesioned skin when compared to healthy skin, together with eosinophilia and high serum IgE 6,15 …”

Section: Introductionmentioning

confidence: 99%

Cytokines in the pruritic papular eruption of HIV

et al. 2000

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Pruritic papular eruption of the acquired immunodeficiency syndrome: predominance of CD8⁺ cells

Cited by 13 publications

References 12 publications

Pruritic Papular Eruption Associated with HIV‐Etiopathogenesis Evaluated by Clinical, Immunohistochemical, and Ultrastructural Analysis

Pruritic Papular Eruption Associated with HIV‐Etiopathogenesis Evaluated by Clinical, Immunohistochemical, and Ultrastructural Analysis

Pruritic papular eruption and eosinophilic folliculitis associated with human immunodeficiency virus (HIV) infection: A histopathological and immunohistochemical comparative study

Cytokines in the pruritic papular eruption of HIV

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Pruritic papular eruption of the acquired immunodeficiency syndrome: predominance of CD8+ cells

Cited by 13 publications

References 12 publications

Pruritic Papular Eruption Associated with HIV‐Etiopathogenesis Evaluated by Clinical, Immunohistochemical, and Ultrastructural Analysis

Pruritic Papular Eruption Associated with HIV‐Etiopathogenesis Evaluated by Clinical, Immunohistochemical, and Ultrastructural Analysis

Pruritic papular eruption and eosinophilic folliculitis associated with human immunodeficiency virus (HIV) infection: A histopathological and immunohistochemical comparative study

Cytokines in the pruritic papular eruption of HIV

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Pruritic papular eruption of the acquired immunodeficiency syndrome: predominance of CD8⁺ cells