Pruritus and mast cell proliferation in the skin of haemodialysis patients

Szepietowski, Jacek; Thepen, Theo; Vloten, W. A. van; Szepietowski, T; Bihari, Ilse C.

doi:10.1007/bf01674408

Cited by 32 publications

(22 citation statements)

References 4 publications

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“…Several reports have indicated that there is a significant relationship between pruritus and higher serum Ca and P levels [12,13,14,15,16]. Parallel to increased serum levels, increased concentrations in the skin may cause pruritus leading to microprecipitation in the skin.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Pruritus in Children on Peritoneal Dialysis

et al. 2008

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Background/Aims: The aim of this study was to evaluate the characteristics of pruritus in pediatric patients undergoing peritoneal dialysis. Patients and Methods: Twenty-seven patients (16 females, 11 males), aged between 5 and 18 years, were evaluated for the presence, intensity, onset, activation time, duration, characteristics, localization and increasing factors for pruritus. The intensity of pruritus was scored using a visual analog scale. Patients were grouped according to the existence of pruritus and other clinical and laboratory parameters (dialysis duration, dialysis adequacy, hemoglobin, blood urea nitrogen, creatinine, Ca, P, albumin, bicarbonate, parathyroid hormone (PTH), C-reactive protein (CRP)) were compared between the 2 groups. Results: The mean age of patients was 11.85 ± 4.4 years. There were 21 patients (77.7%) without pruritus and 6 patients with pruritus (22.2%). Serum P, PTH, CRP levels and Ca×P product were significantly higher in patients with pruritus compared to patients without pruritus (p = 0.027, p = 0.03, p < 0.026, p = 0.031, respectively). In a stepwise logistic regression model, P (p = 0.01), Ca×P product (p = 0.09), PTH (p = 0.03) and CRP (p = 0.02) were independently associated with pruritus. Conclusion: Our study indicates that pruritus remains a common but not troublesome symptom in children on peritoneal dialysis. Higher serum P, Ca×P product, PTH and CRP concentrations appear to be important factors associated with uremic pruritus in this group.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Pruritus in Children on Peritoneal Dialysis

et al. 2008

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“…Despite these significant histological changes, only a few investigators found a correlation with uremic pruritus [32,33]. No difference in the above histology was appreciated in pruritic and nonpruritic uremic patients [9,31]. Mast cell numbers may be an important factor modulating the sensation of itch and the effect of some antipruritic medications.…”

Section: Mast Cells and Autacoidsmentioning

confidence: 99%

“…The pattern of distribution is diffuse rather than localized to the upper dermis with the majority demonstrating degranulation [9,31]. Despite these significant histological changes, only a few investigators found a correlation with uremic pruritus [32,33].…”

Section: Mast Cells and Autacoidsmentioning

confidence: 99%

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Uremic Pruritus – An Update

2001

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“…Studies have shown that uremic patients have increased number of mast cells and also increased histamine levels [17]. Some observed contradictory findings, that even though the mast cells and histamine levels were increased there was no direct correlation between itching and histamine levels [18].…”

Section: Mast Cellsmentioning

confidence: 99%

Uremic pruritus – a review

Pvs¹,

Pk²,

Nethra³

et al. 2016

Glob Dermatol

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Uremic pruritus remains a frequent concern for hemodialysis patients with the most frustrating and disabling symptoms. The word uremic may denote that patients suffer from acute renal injury. Hence it is preferred to use the recent term "chronic kidney disease associated pruritus" (CKD-associated pruritus). The prevalence of CKD-associated pruritus in patients ranges from 15%-90% in various studies.Interestingly, in CKD associated pruritus the skin lesions are not found. The various skin lesions which range from excoriations, impetigo, linear crusts, papules and ulcers are secondary. Other co-existing diseases like cardiovascular diseases, diabetes, hypothyroidism, chronic liver or hematological diseases may challenge the diagnosis and management.The pathophysiology remains unexplained. There may be an imbalance between the antagonistic activities of µ-and] κ-opioid receptors. Itch sensation are correlated with the activation of certain areas in the brain, spatial and temporal aspects may be processed in the primary somatosensory cortex, planning of scratch response in the pre-motor and supplementary motor cortices, and affective and motivational aspects in the anterior cingulate cortex.

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Pruritus and mast cell proliferation in the skin of haemodialysis patients

Cited by 32 publications

References 4 publications

Characteristics of Pruritus in Children on Peritoneal Dialysis

Characteristics of Pruritus in Children on Peritoneal Dialysis

Uremic Pruritus – An Update

Uremic pruritus – a review

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