Pruritus and psoriasis

Abstract

Reference1 Veysey E, Downs AMR. Adverse side-effects following attempted removal of tattoos using a non-laser method.

Factors affecting sleep quality in patients with psoriasis

“…76 This neuropeptide and its neurokinin 1 receptor are found in high concentrations in lesional skin of patients with psoriasis. 14,17 Alterations noted in the epidermis and dermis of these patients as well as symptoms of pruritus may be subsequently mediated by SP through stimulation and recruitment of inflammatory cells and degranulation of mastocytes at the affected areas. 14,17 However, plasma concentrations of SP are not significantly elevated in patients with psoriasis.…”

“…14,17 Alterations noted in the epidermis and dermis of these patients as well as symptoms of pruritus may be subsequently mediated by SP through stimulation and recruitment of inflammatory cells and degranulation of mastocytes at the affected areas. 14,17 However, plasma concentrations of SP are not significantly elevated in patients with psoriasis. 17,77 Effects of SP related to stress, affective disorders, and sleep have also been investigated, demonstrating that stressful stimuli alter SP concentrations in the brain.…”

“…15 As one of the most distressing symptoms of psoriasis, pruritus parallels disease severity. [2][3][4]6,16,17 Furthermore, pruritus significantly impairs quality of life. 15 The association between sleep disturbance and pruritus has been established, but its relationship is not clearly defined.…”

Pruritus und Psoriasis

“…Da zu zählen Neuropeptide, Substanz P (SP), CGRP ("calcitonin generelated peptide"), VIP (vasoaktives intestinales Peptid), In terleukin2 und Opioide [1,4,15,19,20,24,25]. Verglichen mit Hautgesunden war CGRP im Plasma [24] und Gewebe [4] bei Patienten mit pruritogener Psoria sis signifikant erhöht. Neuropeptid Y war im Plasma bei Psoriasispatienten mit Pru ritus im Vergleich zu Psoriasispatienten ohne Pruritus signifikant erniedrigt, wo hingegen SP und VIP erhöht waren [19].…”

“…der Intensität von Pruritus [9,18]. Bei 81% war das Ju cken auf die betroffenen Hautareale be schränkt, bei 19% war auch die nichtbe fallene Haut betroffen [23,24]. Alle Pso riasispatienten, die im Monat vor dem Krankheitsschub Stress gehabt hatten, lit ten an Pruritus [24].…”