Pruritus and skin pain in psoriatic patients: the neglected symptoms

García-Fernández, Laura; Belinchón, Isabel; Pastor‐Tomás, Natalia; Lucas-Costa, Ana; Marín-Cabañas, Irene; Ramos‐Rincón, José‐Manuel

doi:10.1684/ejd.2019.3581

Cited by 3 publications

(3 citation statements)

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“…Psoriasis patients reporting skin pain were younger than those not reporting skin pain [ 26 ], and the proportion of women with skin pain was significantly higher than the proportion of men [ 23 , 26 ], but we did not observe such relations in our population. Additionally, we found no association between the intensity of skin pain and the PASI, which is consistent with some studies [ 27 , 28 ]. However, according to some other authors, skin pain was more frequent in patients with more severe psoriasis [ 21 , 29 ], and improvement in the PASI predicted improvement in skin pain over time [ 31 ].…”

Section: Discussionsupporting

confidence: 93%

“…In our study, 50% of patients with psoriasis experienced cutaneous pain in the past week, and 62.3% of our investigated population perceived skin pain during the whole disease, consistent with the foregoing research outcomes [25][26][27][28][29]. In our study, skin pain was of mild intensity as assessed with different pain assessment tools, in contrast to the results of previous investigations, which most often report skin pain of moderate intensity.…”

Section: Discussionsupporting

confidence: 89%

“…For instance, Misery et al interviewed 244 patients with psoriasis, reporting a prevalence of skin pain of 33.2% with a mean intensity of 5.83/10 points on the VAS scale [26]. In another study, García-Fernández examined 119 patients with moderate-to-severe psoriasis, in which 37.8% reported skin pain of 5.7 ± 2.6 points on the VAS scale [28] compared to the mean VAS of 1.92 ± 2.65 points in our investigation. Furthermore, Patruno et al [25] reported skin pain in the previous week in 43.6% of psoriasis patients with a mean intensity of 7,1 points (NRS) in a studied group of 163 psoriatic individuals.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Characteristics of Cutaneous Pain in Psoriasis

Kotewicz,

Krajewski,

Jaworek

et al. 2024

JCM

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Background: Psoriasis is a common inflammatory disease that is often associated with itch and pain. This study aimed to evaluate the clinical characteristics of skin pain among patients with psoriasis. Materials: A total of 106 patients diagnosed with psoriasis were included in the study (34% female; mean age 42.1 ± 13.0 years). Disease severity was assessed using the Psoriasis Area and Severity Index (PASI). Itch severity was evaluated using the numeric rating scale (NRS) and 4-Item Itch Score (4IIS). The intensity of skin pain was measured through the NRS, short-form McGill pain questionnaire (SF-MPQ), visual analog scale (VAS), and Douleur Neuropathique-4 questionnaire (DN4). Results: In the past week, 84.9% of psoriasis patients reported itch, while 50% of them reported skin pain. The average NRS for itch was 4.52 ± 2.88 points, and the 4IIS yielded a mean score of 6.79 ± 4.37 points. In terms of the intensity of cutaneous pain, the mean NRS was 2.42 ± 2.96 points; the SF-MPQ score averaged 4.84 ± 7.51 points; and the VAS score was 1.92 ± 2.65 points. Furthermore, 17% of adult psoriasis patients reported neuropathic pain. In 84.9% of the participants, skin pain was concurrent with areas affected by itch, while 18.9% of patients exhibited cutaneous pain encompassing all itchy areas. The pain NRS demonstrated significant correlations with the SF-MPQ (r = 0.531, p < 0.001), VAS (r = 0.779, p < 0.001), itch NRS (r = 0.551, p < 0.001), and 4IIS (r = 0.569, p < 0.001). No association was found between the pain NRS and PASI or disease duration. Conclusions: Skin pain of mild intensity and itch of moderate intensity are prevalent symptoms in psoriasis patients. Strong correlations between skin pain and itch can be explained by the process of neurogenic inflammation.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Characteristics of Cutaneous Pain in Psoriasis

Kotewicz,

Krajewski,

Jaworek

et al. 2024

JCM

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Early detection of skin cancer using AI: Deciphering dermatology images for melanoma detection

Deepa,

ALMahadin,

et al. 2024

AIP Advances

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This Review explores the transformative impact of artificial intelligence (AI) on the early detection of skin cancer, with a specific focus on melanoma, a potentially lethal form of the disease. Beginning with an overview of traditional diagnostic methods and their limitations, this paper delves into the evolution of AI within dermatology, emphasizing its application in image analysis and pattern recognition. A comprehensive examination of AI algorithms for melanoma detection, including machine learning and deep learning models, is provided. This Review critically assesses the performance metrics, training datasets, and comparative analyses with traditional methods. Addressing challenges such as data quality, interpretability, and ethical considerations, this paper outlines future directions, emphasizing ongoing research, algorithm improvements, and integration with clinical practices. Case studies and success stories highlight the real-world impact of AI in dermatology. This Review concludes by summarizing key findings and underlining the pivotal role of AI in revolutionizing early melanoma detection, with implications for personalized medicine and enhanced patient outcomes.

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Psychological Aspects of Cutaneous Pain in Psoriasis

Kotewicz,

Krajewski,

Jaworek

et al. 2024

JCM

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Introduction: Psoriasis is a chronic inflammatory disease that negatively impacts patients’ quality of life (QoL) and mental health. Itch and pain are prevalent symptoms of psoriasis and contribute to the psychosocial burden of this disease. This study aimed to evaluate the impact of skin pain on the prevalence and severity of symptoms of anxiety and depression and on the QoL in psoriasis patients. Methods: The studied population comprised 106 adults with psoriasis (34% female; mean age 42.1 ± 13.0 years). Disease severity was measured with the Psoriasis Area and Severity Index (PASI). The intensity of skin pain was assessed with the NRS and the Short Form McGill Pain Questionnaire (SF-MPQ). The Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) questionnaires were used to estimate the severity of depression and anxiety, respectively, as was the Hospital Anxiety and Depression Scale (HADS). Quality of life (QoL) was studied using the Dermatology Life Quality Index (DLQI). Results: Regarding anxiety assessment, females reported significantly higher scores with the HADS-A (8.42 ± 4.85 points vs. 5.14 ± 3.9 points; p < 0.001) and the GAD-7 compared to men (7.50 ± 5.58 points vs. 5.24 ± 4.79 points; p = 0.036). Similarly, the severity of depression was significantly higher in women, as measured with the PHQ-9 (7.50 ± 5.58 points vs. 5.24 ± 4.79 points, p = 0.021). Psoriasis patients with skin pain scored significantly higher in HADS Total score (p = 0.043), HADS-A (p = 0.022), PHQ-9 (p = 0.035), and DLQI (p < 0.001) than the rest of the studied group. The intensity of skin pain measured with the SF-MPQ correlated significantly with HADS Total score (p = 0.021), HADS-A (p < 0.001), HADS-D (p = 0.038), and PHQ-9 (p < 0.001). Additionally, there was a significant correlation between the intensity of cutaneous pain assessed using the VAS and the PHQ-9 (p = 0.022). Conclusions: Skin pain significantly influences the well-being of patients with psoriasis as well as the symptoms of anxiety and depression. In particular, women with psoriasis are at increased risk of developing anxiety and depression. Our findings underline the necessity for a multidisciplinary approach to the management of this dermatosis.

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Pruritus and skin pain in psoriatic patients: the neglected symptoms

Cited by 3 publications

References 10 publications

Clinical Characteristics of Cutaneous Pain in Psoriasis

Clinical Characteristics of Cutaneous Pain in Psoriasis

Early detection of skin cancer using AI: Deciphering dermatology images for melanoma detection

Psychological Aspects of Cutaneous Pain in Psoriasis

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