Prussian blue nanozymes: progress, challenges, and opportunities

He, Hongliang; Long, Mengmeng; Duan, Yifan; Gu, Ning

doi:10.1039/d3nr01741a

Cited by 19 publications

(5 citation statements)

References 120 publications

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“…In this nano platform, the drug can be released slowly, which signi cantly improves the therapeutic effect of the drug. In addition, Pb-based nanoplatforms can be designed to have convenient sizes active sites, which can effectively target speci c cells and also help improve drug e cacy [12,13]. However, previous studies have found this regulation less effective under physiological conditions.…”

Section: Introductionmentioning

confidence: 99%

Artificial nano platform for controlling bone microenvironment to reduce bone loss

Gao,

Guo,

Chen

et al. 2024

Preprint

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Treatment on the regeneration of osteoporosis (OP) remains a challenge due to the severe dysregulation of the bone microenvironment. With the continuous development of nano-platform technology, new nanomaterials have become a hot topic in recent years. In recent research reports, Prussian blue, characterized by its diversity and high-cost performance, has gained attention. Therefore, we synthesized and developed a new Prussian blue particle, Pb-Fe-Cs, which has ability to clear reactive oxygen species (ROS) and specific regulatory effect on the inflammatory micro-environment. As a class of active metal ions, both Fe and Cs have specific antioxidant capacities. In summary, the combination of these two elements can significantly reduce the occurrence of bone loss. The constructed Pb-Fe-Cs nanase has the ability to induce bone marrow mesenchymal stem cells (BMSCs) to differentiate into osteoblasts, minimizing damage, osteoclast formation, and bone loss when oxidative stress occurs in the bone microenvironment. In vivo experiments confirmed that Pb-Fe-Cs promotes the formation of osteoblasts, reduces osteoclasts. These results suggest that the microenvironmental regulatory effect of these artificial biodegradable nanoplatforms is beneficial for treating OP. This study opens up an exciting prospect for applying OP therapy and supports the clinical significance of Pb-Fe-Cs.

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Section: Introductionmentioning

confidence: 99%

Artificial nano platform for controlling bone microenvironment to reduce bone loss

Gao,

Guo,

Chen

et al. 2024

Preprint

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“…Nanoparticles of PB and its analogues are recognized as effective PTT agents and have been widely used to combat complex diseases such as cancer and neurodegenerative disorders. 21 The doping performances of PB nanocrystals by Mn, Gd, Cu, Cr, and Zn elements have been studied, 22−26 yet there has been no direct investigation into the doping of PB by Ag + ions, although PB nanocubes decorated with silver nanoparticles were reported. 16 The AgPB nanoparticles exhibit appreciable photothermal effect, and moreover, the releases of Ag + and Fe 2+/3+ ions occur spontaneously under an 808 nm near-infrared (NIR) laser treatment.…”

Section: ■ Introductionmentioning

confidence: 99%

“…To address this limitation, we present the preparation of Ag + ion-doped Prussian blue (AgPB) nanoparticles through a straightforward one-pot reaction, with Ag + ions interstitially displacing a part of K + ions in the PB crystals. Nanoparticles of PB and its analogues are recognized as effective PTT agents and have been widely used to combat complex diseases such as cancer and neurodegenerative disorders . The doping performances of PB nanocrystals by Mn, Gd, Cu, Cr, and Zn elements have been studied, − yet there has been no direct investigation into the doping of PB by Ag + ions, although PB nanocubes decorated with silver nanoparticles were reported .…”

Section: Introductionmentioning

confidence: 99%

Dental Caries Management with Antibacterial Silver-Doped Prussian Blue Hydrogel by the Combined Effects of Photothermal Response and Ion Discharge

Li,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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Caries is a destructive condition caused by bacterial infection that affects the hard tissues of the teeth, significantly reducing the quality of life for individuals. Photothermal therapy (PTT) offers a noninvasive and painless treatment for caries, but the use of unsafe laser irradiance limits its application. To address this challenge, we prepared nanoparticles of silver ion-doped Prussian blue (AgPB), which was encased within cationic guar gum (CG) to form the antibacterial PTT hydrogel CG-AgPB with a photothermal conversion efficiency of 34.4%. When exposed to an 808 nm laser at a power density of 0.4 W/cm2, the hydrogel readily reached a temperature of over 50 °C in just 3 min, synchronized by the discharge of Ag+ ions from the interstitial sites of AgPB crystals, resulting in broad-spectrum and synergistic antibacterial activities (>99%) against individual oral pathogens (Streptococcus sanguinis, Streptococcus mutans, and Streptococcus sobrinus) and pathogen-induced biofilms. In vivo, CG-AgPB-mediated PTT demonstrated a capability to profoundly reduce the terminal number of cariogenic bacteria to below 1% in a rat model of caries. Given the outstanding biocompatibility, injectability, and flushability, this CG-AgPB hydrogel may hold promise as a next-generation oral hygiene adjunct for caries management in a clinical setting.

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“…The use of nanozymes in immunosensors and immunoassays is summarized in some reviews [40][41][42], as is their use specifically for food control [43,44]. Several studies have shown that in nanozyme-based LFIAs with catalytic enhancement, the analyte's limit of detection (LOD) can be reduced due to increased coloration in the bands of test strips [30,[45][46][47].…”

Section: Introductionmentioning

confidence: 99%

“…Before the discovery of catalytic properties, blue-colored Prussian blue was used as a pigment. Later, Prussian blue found application as a peroxidase-mimic catalytic material for the selective reduction of hydrogen peroxide [47,48]. Due to their very high catalytic activity, enzymatic selectivity, ease of synthesis, stability, and low cost, PBNPs are a promising alternative to expensive and insufficiently stable natural peroxidase.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Immunochromatographic Detection of Porcine Myoglobin as Biomarker for Meat Authentication Using Prussian Blue Nanozyme

Hendrickson,

Zvereva,

Dzantiev

et al. 2023

Foods

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This study was aimed at the sensitive immunodetection of porcine myoglobin (MG) as a species-specific biomarker in meat products. The enhanced lateral flow immunoassay (LFIA) was created in the sandwich format using monoclonal antibodies (Mab) with specificity to porcine MG and labeled by Prussian blue nanoparticles (PBNPs) as peroxidase-mimicking nanozymes. Signal amplification was provided by the colored product of oxidation catalyzed by the PBNPs. Several Mab–PBNP conjugates with different antibody loads were synthesized; the one that provided the best analytical characteristics of the LFIA was selected. Advanced optimization of the test system was carried out. As a result, the visual limit of detection (LOD) of MG was 1.5 ng/mL. Involvement of the catalytic nanozyme properties allowed the LOD to be decreased by ~9 times in comparison to the LFIA based on gold nanomarkers, and by ~27 times compared to the LFIA based on PBNP coloration. The assay time was 30 min, including catalytic enhancement. A simple technique of meat sample pre-treatment aimed at effective MG extraction and matrix disposal was proposed. The specificity of the LFIA towards the pork meat was demonstrated. The applicability of the created test system was shown by testing extracts obtained from finished meat products.

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Prussian blue nanozymes: progress, challenges, and opportunities

Abstract: Prussian Blue Nanozymes (PBNZ) have emerged as a highly efficient agent for reactive oxygen species (ROS) elimination, owing to their multiple enzyme-like properties encompassing catalase (CAT), peroxidase (POD), and superoxide...

Cited by 19 publications

References 120 publications

Artificial nano platform for controlling bone microenvironment to reduce bone loss

Artificial nano platform for controlling bone microenvironment to reduce bone loss

Dental Caries Management with Antibacterial Silver-Doped Prussian Blue Hydrogel by the Combined Effects of Photothermal Response and Ion Discharge

Highly Sensitive Immunochromatographic Detection of Porcine Myoglobin as Biomarker for Meat Authentication Using Prussian Blue Nanozyme

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