Przypadek pokrzywki autoimmunologicznej współistniejącej z autoimmunologicznym zespołem wielogruczołowym typu III związanym z chorobą Hashimoto, cukrzycą typu 1 i bielactwem

Abstract

We present a case of autoimmune polyglandular syndrome type III (APS III) associated with Hashimoto's disease, type 1 diabetes mellitus, vitiligo and autoimmune urticaria. This rare genetic disorder occurs with unknown frequency in the Polish population. It is characterised by endocrine tissue destruction resulting in the malfunction of multiple organs. Several cases of APS III associated with organ-specific autoimmune diseases such as coeliac disease, hypogonadism and myasthenia gravis, as well as organ-nonspecific or systemic autoimmune diseases such as sarcoidosis, Sjögren syndrome, and rheumatoid arthritis have been described. To the best of our knowledge, we here describe the first case of APS III associated with autoimmune thyroiditis, type 1 diabetes mellitus, vitiligo and autoimmune urticaria in an adult patient.

Metabolic-targeted Combination Therapy With Dichloroacetate and Metformin Suppresses Glioblastoma Cell Line GrowthIn VitroandIn Vivo

“…MET can activate AMP activated protein kinase (AMPK) (17,18), a powerful mediator in cellular energy metabolism (19). AMPK inhibits protein synthesis and induces cell cycle arrest (20), affects cell growth by inhibiting the mTOR pathway, which in turn plays an important role in metabolism, growth and proliferation of cancer cells (21). It was suggested by Evans and her team in 2005 that the use of MET may be related to reduced incidence of cancer (22).…”