Ps 08-85 Association of Aldosterone Synthase (Cyp11b2) Gene Polymorphisms With Obesity in Essential Hypertensive Children and Adolescents From the Urals

Samarina, O. P.; Ковтун, О. П.; Chuykov, Alexander; Sozonov, Andrey; Устюжанина, М. А.; Trunova, Yulia; Averianov, Oleg

doi:10.1097/01.hjh.0000500779.78710.28

Cited by 2 publications

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“…Эти исследования и сопровождавшие их экспериментальные работы позволили сформулировать концепцию «тысячедневного окна возможностей», в течение которого возможно репрограммирование патологии [69]. Было показано, что у детей с полиморфизмом генов жирового, углеводного обмена, ренин-ангиотензиновой системы, способных индуцировать развитие метаболического синдрома и артериальной гипертензии, полноценное питание грудным молоком уменьшает вероятность реализации такого сценария в последующей жизни [68,70].…”

Section: повышенное питание матери и факторы риска развития кардиометunclassified

Maternal Nutrition and the Problem of Intrauterine Disease Programming in Children

et al. 2018

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Environmental conditions during perinatal development such as maternal undernutrition or overnutrition can program changes in the integration among physiological systems leading to cardio-metabolic diseases. This phenomenon can be understood in the context of the phenotypic plasticity and refers to the adjustment of a phenotype in response to environmental input without genetic change. Experimental studies indicate that fetal exposure to an adverse maternal environment may alter the morphology and physiology that contribute to the development of cardio-metabolic diseases. The significance and role of genetic polymorphism, markers of chronic inflammation, oxidative stress, endothelial dysfunction, leptin synthesis disruption, rennin-angiotensin system in intrauterine cardio-metabolic disease programming are discussed. The study demonstrated that both maternal protein restriction and overnutrition alter the central and peripheral control of arterial pressure and metabolism. Breastfeeding may have beneficial effect on obesity risk later in life in genetically predisposed groups. Understanding the mechanisms which affect health outcomes in the offspring influenced by the macronutrient composition of the maternal diet during pregnancy or lactation may lead to new maternal nutrition recommendations, disease prevention strategies, and therapies that reduce the increasing incidence of cardio-metabolic diseases in children and adults.

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Section: повышенное питание матери и факторы риска развития кардиометunclassified