PS3:58 Lipid profile characterisation in patients with juvenile sle with and without lupus nephritis – experience of a portuguese centre

Abstract

sites and relation to clinical characteristics, laboratory features and disease activity. Patients and methods Medical records of 250 Egyptian SLE patients attending the Rheumatology department, Cairo University hospitals were reviewed retrospectively for the clinical and laboratory features, SLE disease activity index (SLEDAI) and treatment received. Results Infection was found in 119 (47.6%) patients, with bacterial infection being the commonest in 99 (83%) followed by fungal infection in 30 (25%) and viral infection in 22 (18.5%). The commonest site of infection was the skin (37%) followed by the urinary tract (31%) and chest (19%). In SLE patients with infection there was a significant increase in the frequency of malar rash (p=0.001), photosensitivity (p=0.01), oral ulcers (p<0.001), alopecia (p=0.017) and Raynauds (p=0.017) compared to those without infection. Pulmonary and neuropsychiatric manifestations were also significantly increased in those with infection (p=0.001 and p<0.001). A significantly higher number of patients with infection were receiving pulse steroids (p=0.016), cyclophosphamide (p=0.011) and a higher oral prednisolone dose (p=0.03). The SLEDAI was significantly higher (26.02±8.23) in those with infection compared to those without (15.57±6.43) (p<0.001). C-reactive protein (CRP) was significantly higher in those with infection (p<0.001). On performing a logistic regression analysis, only SLEDAI (p<0.001) and CRP (p<0.001) were significant predictors of infection. Conclusion Disease activity and CRP are important predictors for infection in SLE patients.

Cardiovascular risk factors and complications in patients with systemic lupus erythematosus with and without nephritis: a systematic review and meta-analysis

“…10 two-arm studies (n=1207) had the required data for analysing the relationship between LN and lipid profile. 4 24 25 27 32 35 37 38 41 43 Seven of them included the mean total TC levels, 24 25 35 37 38 41 43 while six included the mean HDL, LDL and TG levels. 24 25 35 37 41 43 Three studies reported the OR of hyperlipidaemia.…”

“…4 24 25 27 32 35 37 38 41 43 Seven of them included the mean total TC levels, 24 25 35 37 38 41 43 while six included the mean HDL, LDL and TG levels. 24 25 35 37 41 43 Three studies reported the OR of hyperlipidaemia. 4 27 32 The pooled outcomes showed that patients with SLE with LN were associated with significantly higher TC (MD=0.44, 95% CI=0.12 to 0.76, p=0.006, I 2 =73%) ( figure 3A ), LDL (MD=0.37, 95% CI=0.02 to 0.71, p =0.04, I 2 =70%) ( figure 3B ) and risk of hyperlipidaemia (OR=11.03, 95% CI=4.20 to 28.95, p<0.00001, I 2 =0%) ( figure 3E ) within the random-effects model.…”