PSA bounce predicts early success in patients with permanent iodine-125 prostate implant

Patel, C.; Elshaikh, Mohamed A.; Angermeier, Kenneth W.; Ulchaker, James; Klein, Eric A.; Chehade, Nabil El Hage; Wilkinson, Dominic; Reddy, Chandana A.; Ciezki, Jay P.

doi:10.1016/j.urology.2003.08.025

Cited by 75 publications

(62 citation statements)

References 7 publications

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“…Of both practical and theoretical interest, prostate-specific antigen (PSA) kinetics after PB differ from those after external beam radiation therapy in that PSA bounces (benign rises in PSA) are frequently observed and have been reported in several of brachytherapy studies. The incidence of PSA bounce varies according to the threshold definition used and ranges between 20% and 84% (4)(5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Phoenix Definition of Biochemical Failure After 125I Prostate Brachytherapy: Can PSA Kinetics Distinguish PSA Failures From PSA Bounces?

Thompson

Keyes

Pickles

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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Section: Introductionmentioning

confidence: 99%

Evaluating the Phoenix Definition of Biochemical Failure After 125I Prostate Brachytherapy: Can PSA Kinetics Distinguish PSA Failures From PSA Bounces?

Thompson

Keyes

Pickles

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…2 Approximately 15%-60% of hormone-naive patients show a temporary PSA elevation after brachytherapy. [2][3][4][5][6][7][8][9][10][11][12] It has been proposed that this PSA "bounce" is probably the result of some mechanism compromising membrane integrity; that is, radiation-induced prostatitis, in PSA-producing epithelium. In 1997, the American Society for Therapeutic Radiology and Oncology (ASTRO) consensus conference recommended three consecutive increases in PSA levels after the nadir, with readings spaced 3-6 months apart, as the defi nition of biochemical failure.…”

Section: Introductionmentioning

confidence: 99%

Prediction of PSA bounce after permanent prostate brachytherapy for localized prostate cancer

et al. 2009

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“…All patients had at least 1 year of follow-up. PSA bounce was de!ined as an absolute increase of 0.2ng/ml from the previous PSA level, followed by a subsequent decrease (25) .…”

Section: Methodsmentioning

confidence: 99%

Prostate-specific antigen kinetics after hypofractionated stereotactic body radiotherapy for localized prostate cancer

Kim

Phak

Kim

2016

IJRR

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Background: stereotac c body radiotherapy (SBRT) has emerged as an effec ve treatment for localized prostate cancer. However, prostate-specific an gen (PSA) kine cs a'er SBRT has not been well characterized. The objec ve of the current study is to analyze the rate of PSA decline and PSA nadir following hypofractonated SBRT in localized prostate cancer. Materials and Methods: From 2008 to 2014, thirty-nine pa ents newly diagnosed, localized prostate (25.6% low risk, 66.7% intermediate risk and 7.7% high risk) cancer were treated with SBRT using Cyberknife. Total dose of 36.25 Gy in 5 frac ons of 7.25 Gy were administered. No one received androgen depriva on therapy (ADT). PSA nadir and rate of change in PSA (slope) were calculated and compared. Results: With a median follow-up of 52 months (range, 13-71), the median rates of decline of PSA were -0.372, -0.211 and -0.128 ng/mL/month, respec vely, for dura ons of 1, 2 and 3 years a'er radiotherapy, respec vely. The decline of PSA was maximal in the first year and con nuously decreased for dura ons of 2 and 3 year. The median PSA nadir was 0.28 ng/mL a'er a median 33 months. There was one biochemical failure, occurring in a high risk pa ent. 5-year actuarial biochemical failure (BCF) free survival was 94.2%. Conclusion: In this report of localized prostate cancer, con nuous decrease of PSA level for dura on 1, 2 and 3 year following SBRT using Cyberknife resulted in lower PSA nadir. Also, SBRT leaded to long-term favorable BCF-free survival.

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PSA bounce predicts early success in patients with permanent iodine-125 prostate implant

Cited by 75 publications

References 7 publications

Evaluating the Phoenix Definition of Biochemical Failure After 125I Prostate Brachytherapy: Can PSA Kinetics Distinguish PSA Failures From PSA Bounces?

Evaluating the Phoenix Definition of Biochemical Failure After 125I Prostate Brachytherapy: Can PSA Kinetics Distinguish PSA Failures From PSA Bounces?

Prediction of PSA bounce after permanent prostate brachytherapy for localized prostate cancer

Prostate-specific antigen kinetics after hypofractionated stereotactic body radiotherapy for localized prostate cancer

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