2001
DOI: 10.1002/dc.2027
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Pseudallescheria: An underdiagnosed fungus?

Abstract: Pseudallescheria has been identified as one of the "clinically significant emerging mycoses" but has received little attention in the cytology literature. Recognition of this fungus is of particular importance clinically, because unlike most other fungi (including Aspergillus, with which it is most frequently confused), Pseudallescheria is not effectively treated with amphotericin B, the most frequently and often the only antifungal agent administered. Features helpful in the diagnosis of Pseudallescheria in c… Show more

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Cited by 25 publications
(28 citation statements)
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“…However, Scedosporium and Aspergillus may have some differences in histopathological preparations of tissue and fluids. Aspergillus displays a regular, dichotomous branching pattern in cytology and histopathological sections, while Scedosporium may present a more irregular branching (460). Similar to the case for Aspergillus fumigatus, branching in Scedosporium spp.…”
Section: Histopathologymentioning
confidence: 81%
See 1 more Smart Citation
“…However, Scedosporium and Aspergillus may have some differences in histopathological preparations of tissue and fluids. Aspergillus displays a regular, dichotomous branching pattern in cytology and histopathological sections, while Scedosporium may present a more irregular branching (460). Similar to the case for Aspergillus fumigatus, branching in Scedosporium spp.…”
Section: Histopathologymentioning
confidence: 81%
“…Scedosporium spp. may also present terminal or intercalary chlamydospores (460) that can be confused with yeasts.…”
Section: Histopathologymentioning
confidence: 99%
“…and other hyphomycete fungi, leading to frequent misidentification [7•, 20]. Some experts testify that in contrast to the regular dichotomous branching pattern typical of Aspergillus hyphae, Scedosporium hyphae are slightly more irregular, with multiple branching at acute angles, providing a distinguishing characteristic [20,21]; however, in practice, this was found to have low discriminatory value. Others reported unique histopathological characteristics observed, which include parallel hyphae bridging at right angles, in H patterns, and intravascular conidiation and conidia present in tissue are terminal or intercalary globose chlamydospores [7•, 21, 22].…”
Section: Histopathology Stainsmentioning
confidence: 99%
“…Detection of invasive P. boydii infections, based on cytopathology and histopathology, is problematic since it can occur in tissue and bronchoalveolar and bronchial washing specimens with other hyaline septated fungi, such as Aspergillus and Fusarium spp. (7,23,53,60), which exhibit similar morphological characteristics upon microscopic examination (2,23,24,28,37,44,53,60). Early diagnosis of infection by P. boydii and differentiation from other agents of hyalohyphomycosis is imperative, since it is refractory to antifungal compounds, such as amphotericin B, that are commonly administered for the control of fungal infections (10,39,58).…”
mentioning
confidence: 99%
“…boydii is thought to be an underdiagnosed fungus (60), and misidentification is one of the reasons that the mortality rate due to invasive pseudallescheriasis is high. Detection of invasive P. boydii infections, based on cytopathology and histopathology, is problematic since it can occur in tissue and bronchoalveolar and bronchial washing specimens with other hyaline septated fungi, such as Aspergillus and Fusarium spp.…”
mentioning
confidence: 99%