Pseudo-Aids

Walker, Dena; Lilleyman, J S

doi:10.1016/s0140-6736(83)90323-9

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…Wird nun eine Patientengruppe mit einer Kontrollgruppe verglichen, die zu einem systematisch anderen Zeitpunkt zur Blutentnahme kommt werden schon aufgrund dieser Bedingung signifikante Unterschiede festgestellt ohne daß dieser Beobachtung ein Krankheitswert zukommt. Auch manifeste Infekte oder nur eine Insolation können die OKT 4/OKT 8-Ratio beeinflussen (28,29). Die Randbedingungen und die Störanfälligkeit dieser Untersuchungsmethode sind also noch nicht hinlänglich bekannt, dadurch wird die Verwendung dieses Parameters zur Screening-Untersuchung z.…”

Section: Diskussionunclassified

Immunitätslage bei Blutspendern und Hämophilen: Bericht über eine laufende Studie

Köhler¹,

Hellstern²,

Kiehl³

et al. 1984

LaboratoriumsMedizin

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The clinical and immunological Status of blood donors f hemophiliacs, and drug abusers is determined in a prospective study. Preliminary results indicate that Hepatitis B-markers and elevated IgG-concentrations are more frequent in severe hemophiliacs. Additionally, these patients demonstrate decreased reactions toward recall-antigens using a skin-test (Multitest®) f äs well äs an increased percentage of OKT 8 (suppressor) lymphocytes. In patients with mild hemophilia, the transaminases and IgG-concentrations are altered similar to severe hemophiliacs, however, Hepatitis B-markers, cell-mediated immunity (Multitest®) and lymphocyte subsets are comparable to blood donors. Predictivity and relevance of these Undings for the development of acquired immune deficiency syndrome (AIDS) cannot yet be conclusively determined.

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Section: Diskussionunclassified

Immunitätslage bei Blutspendern und Hämophilen: Bericht über eine laufende Studie

Köhler¹,

Hellstern²,

Kiehl³

et al. 1984

LaboratoriumsMedizin

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A critical analysis of the HIV-T4-cell-AIDS hypothesis

Papadopulos-Eleopulos

Turner

Papadimitriou

et al. 1996

AIDS: Virus- Or Drug Induced?

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Impaired natural killer cell function in hemophiliacs with or without continuous substitution

Porzsolt

Hauser

Piper

et al. 1984

Blut

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In the present study, 28 hemophiliacs substituted continuously and 5 hemophiliacs who had received almost no blood products were investigated. Cells of OKT 3+, OKT 4+, and OKT 8+ subsets were counted. Percoll separated fractions of peripheral blood mononuclear cells were examined by morphological criteria and were tested for NK cell activity. We found that the NK cell activity of both groups of hemophiliacs was decreased on testing Ficoll separated cells or low density Percoll separated cells. Normal NK cell activity was found in medium density cells of hemophiliacs. Two possible explanations are discussed: first, the NK cell activity may be suppressed in hemophiliacs and secondly, there may be a block in maturation of NK cell activity. It is unlikely that chronic substitution by blood products counts for these alterations. The possible role of chronic infections is discussed.

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Pseudo-Aids

Cited by 6 publications

References 4 publications

Immunitätslage bei Blutspendern und Hämophilen: Bericht über eine laufende Studie

Immunitätslage bei Blutspendern und Hämophilen: Bericht über eine laufende Studie

A critical analysis of the HIV-T4-cell-AIDS hypothesis

Impaired natural killer cell function in hemophiliacs with or without continuous substitution

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