This study explores the intersection of meditation and neurostimulation, focusing on Focused Ultrasound Stimulation (FUS) as a potential aid in achieving meditative states. We compared the effects of FUS to sham stimulation in experienced and novice meditators, targeting three specific brain regions: the posterior cingulate cortex (PCC), the caudate nucleus (CN), and the insular cortex (Iav). Our investigation is particularly relevant given the growing evidence of meditation's positive impact on mental health and well-being, and the challenges many face in maintaining regular meditative practice. The chosen targets are backed by empirical and theoretical support, reflecting their roles in meditative states and related cognitive functions. This study not only contributes to understanding the neural mechanisms of meditation but also explores the potential of FUS in enhancing meditative practices, especially for those who struggle to achieve these states independently.