Pseudo‐maple syrup urine disease due to maternal prenatal ingestion of fenugreek

Korman, Stanley H.; Cohen, Eugene J.; Preminger, Avia

doi:10.1046/j.1440-1754.2001.00617.x

Cited by 31 publications

(15 citation statements)

References 8 publications

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“…94 Use of fenugreek in lactating women also is associated with maple-syrup odor in infants. 95 Available data do not support the routine use of other herbal products, such as fennel, to facilitate lactation. 96 In summary, galactagogues have a limited role in facilitating lactation and have not been subject to full assessments of safety for the nursing infant.…”

Section: Galactagoguesmentioning

confidence: 99%

The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics

Sachs¹

2013

Pediatrics

468

198

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Many mothers are inappropriately advised to discontinue breastfeeding or avoid taking essential medications because of fears of adverse effects on their infants. This cautious approach may be unnecessary in many cases, because only a small proportion of medications are contraindicated in breastfeeding mothers or associated with adverse effects on their infants. Information to inform physicians about the extent of excretion for a particular drug into human milk is needed but may not be available. Previous statements on this topic from the American Academy of Pediatrics provided physicians with data concerning the known excretion of specific medications into breast milk. More current and comprehensive information is now available on the Internet, as well as an application for mobile devices, at LactMed (http://toxnet.nlm.nih.gov). Therefore, with the exception of radioactive compounds requiring temporary cessation of breastfeeding, the reader will be referred to LactMed to obtain the most current data on an individual medication. This report discusses several topics of interest surrounding lactation, such as the use of psychotropic therapies, drugs to treat substance abuse, narcotics, galactagogues, and herbal products, as well as immunization of breastfeeding women. A discussion regarding the global implications of maternal medications and lactation in the developing world is beyond the scope of this report. The World Health Organization offers several programs and resources that address the importance of breastfeeding (see http://www.who.int/topics/breastfeeding/en/).

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Section: Galactagoguesmentioning

confidence: 99%

The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics

Sachs¹

2013

Pediatrics

468

198

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“…Despite its interesting proprieties, fenugreek use remains limited because, after ingestion, a bad taste and odour appear, called ''maple syrup" odour in human sweat and urine (Bartley, Hiltry, Andreson, Clairemont, & Maschke, 1981;Korman, Cohen, & Preminger, 2001). In fact, the presence of this ''maple syrup" odour in the sweat and urine of newborn infants may also reveal maple syrup urine disease (MSUD), which is an inborn error of amino acid metabolism leading to neurological damage and mental retardation.…”

Section: Introductionmentioning

confidence: 99%

“…The same odour may also be detected exuding from the mother's skin. ''Pseudo-MSUD" in newborn infants can also result from postnatal fenugreek exposure via mother's breast milk (Korman et al, 2001). Moreover, in Middle East, India and Mediterranean countries when the seeds are used as home remedies, several cases of ''pseudo-MSUD" have been reported after ingestion of seed infusion (Bartley et al, 1981;Korman et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…''Pseudo-MSUD" in newborn infants can also result from postnatal fenugreek exposure via mother's breast milk (Korman et al, 2001). Moreover, in Middle East, India and Mediterranean countries when the seeds are used as home remedies, several cases of ''pseudo-MSUD" have been reported after ingestion of seed infusion (Bartley et al, 1981;Korman et al, 2001). Analysis by enantioselective multidimensional gas chromatography-mass spectrometry of urine samples revealed the presence of 4,5-dimethyl-3-hydroxy-2[5H] furanone (sotolon) in seven MSUD patients (Podebrad et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Analysis of human male armpit sweat after fenugreek ingestion: Instrumental and sensory optimisation of the extraction method

et al. 2010

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“…Interestingly, there are case reports of neonates being born with a peculiar odor following maternal consumption of fenugreek just before delivery, which supports the transplacental passage of fenugreek compounds to the fetus [13,19].…”

Section: Fenugreek (Trigonella Foenum Graecum)mentioning

confidence: 87%

Herbal laxatives and antiemetics in pregnancy

Samavati

Ducza

Hajagos-Tóth

et al. 2017

Reproductive Toxicology

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a b s t r a c tConstipation appears in the 2nd and 3rd trimester of pregnancy, while nausea is the strongest in the 1st trimester. This review summarizes the applicability of herbal laxatives and antiemetics in pregnancy.A human study has shown that flax oil as laxative is safe from 2nd trimester. Human data is not available about the rhubarb, but animal studies reveal that its emodin content induces fetal abnormalities. Fenugreek induces teratogenic malformation both in human and animals. Senna seed is proved as a safe laxative in pregnancy. The antiemetic ginger is safe during 1st trimester, but it reduces the gestational period when applied from the 2nd trimester. Cannabis induces fetal neurological disorders while fennel can shorten the gestational age.There is herbal alternative for laxative therapy (senna) for the whole length of pregnancy, but nausea and vomiting might be reduced by herbal medicine (ginger) safely in the 1st trimester, only.

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Pseudo‐maple syrup urine disease due to maternal prenatal ingestion of fenugreek

Cited by 31 publications

References 8 publications

The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics

The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics

Analysis of human male armpit sweat after fenugreek ingestion: Instrumental and sensory optimisation of the extraction method

Herbal laxatives and antiemetics in pregnancy

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