Pseudo-spin model for the microtubule wall in external field

Chen, Ying; Xijun, Qiu; Dong, Xianlin

doi:10.1016/j.biosystems.2005.06.005

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…The kink-like excitation or traveling solitary wave partly relies on this elastic coupling, and as a result, the solitary wave carries the free portion of this energy of GTP hydrolysis. This is in agreement with a pseudo-spin model of GTP hydrolysis that similarly suggests GTP hydrolysis is a critical factor in determining the dipole state of the tubulin dimer [ 71 ]. Also, there is a double-well potential in the tubulin dimer that can be attributed to a mobile electron, which is localized either to the α - or β-tubulin dimer [ 71 , 72 ].…”

Section: Microtubules Propagate and Amplify Electrical Signalssupporting

confidence: 88%

“…This is in agreement with a pseudo-spin model of GTP hydrolysis that similarly suggests GTP hydrolysis is a critical factor in determining the dipole state of the tubulin dimer [ 71 ]. Also, there is a double-well potential in the tubulin dimer that can be attributed to a mobile electron, which is localized either to the α - or β-tubulin dimer [ 71 , 72 ]. Viewed in the pseudo-spin model, a state change of this mobile electron would be coupled to GTP hydrolysis.…”

Section: Microtubules Propagate and Amplify Electrical Signalssupporting

confidence: 88%

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Neural cytoskeleton capabilities for learning and memory

2009

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This paper proposes a physical model involving the key structures within the neural cytoskeleton as major players in molecular-level processing of information required for learning and memory storage. In particular, actin filaments and microtubules are macromolecules having highly charged surfaces that enable them to conduct electric signals. The biophysical properties of these filaments relevant to the conduction of ionic current include a condensation of counterions on the filament surface and a nonlinear complex physical structure conducive to the generation of modulated waves. Cytoskeletal filaments are often directly connected with both ionotropic and metabotropic types of membraneembedded receptors, thereby linking synaptic inputs to intracellular functions. Possible roles for cable-like, conductive filaments in neurons include intracellular information processing, regulating developmental plasticity, and mediating transport. The cytoskeletal proteins form a complex network capable of emergent information processing, and they stand to intervene between inputs to and outputs from neurons. In this manner, the cytoskeletal matrix is proposed to work with neuronal membrane and its intrinsic components (e.g., ion channels, scaffolding proteins, and adaptor proteins), especially at sites of synaptic contacts and spines. An information processing model based on cytoskeletal networks is proposed that may underlie certain types of learning and memory.

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Section: Microtubules Propagate and Amplify Electrical Signalssupporting

confidence: 88%

Section: Microtubules Propagate and Amplify Electrical Signalssupporting

confidence: 88%

Neural cytoskeleton capabilities for learning and memory

2009

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“…5). Microtubules and actin filaments of the cytoskeleton are capable of transmitting electrical signals ( 217,218,219,220,221,222 ) and are comparable to a RCL circuit, having resistance, non-linear capacitance and inductance ( 223,224,225,226,227,228,229,230 ). Both are present, especially in the apical region of the cytoskeleton, forming part of the cuticular plate and reticular lamina ( 231).…”

Section: The Destruction Of the Cytoskeleton Annihilates The Electric...mentioning

confidence: 99%

Overt and covert paths for sound in the auditory system of mammals

Auriol¹,

Béard²,

Bibé³

et al. 2019

Preprint

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Current scientific consensus holds that sound is transmitted, solely mechanically, from the tympanum to the cochlea via ossicles.But this theory does not explain the hearing extreme quality regarding high frequencies in mammals. So, we propose a bioelectronic pathway (the covert path) that is complementary to the overt path..We demonstrate experimentally that the tympanum produces piezoelectric potentials isochronous to acoustic vibrations thanks to its collagen fibers and that their amplitude increases along with the frequency and level of the vibrations. This finding supports the existence of an electrical pathway, specialized in transmitting high-frequency sounds, that works in unison with the mechanical pathway. A bio-organic triode, similar to a field effect transistor, is the key mechanism of our hypothesized pathway. We present evidence that any deficiency along this pathway produces hearing impairment. By augmenting the classical theory of sound transmission, our discovery offers new perspectives for research into both normal and pathological audition and may contribute to an understanding of genetic and physiological problems of hearing. Approval for the studyThe official title of this research is " Non-invasive Study in vivo of the generation of microvoltages by the tendons and the tympanum when they are subjected to moderate sound stimulations". This work was promoted by CNRS-INSB (ID RCB N°2012-A01375-38; protocole12 008), Paris (France). This study was carried out in accordance with the recommendations

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“…Accordingly, the solitary waves carry the free portion of this energy of GTP hydrolysis. There exists a double-well electrostatic potential within the tubulin dimer as experienced by a mobile electron that can be localized either to the α-or β-tubulin dimer [51,52]. There exists a double-well electrostatic potential within the tubulin dimer as experienced by a mobile electron that can be localized either to the α-or β-tubulin dimer [51,52].…”

Section: Microtubules: Ferroelectric and Pyroelectric Propertiesmentioning

confidence: 99%

The Cytoskeleton as a Nanoscale Information Processor: Electrical Properties and an Actin-Microtubule Network Model

Woolf¹,

Priel²,

Tuszyński³

2009

Nanoneuroscience

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One of the major goals of nanotechnology is to advance the field of information processing. The central processing units of the future are likely to be quite different from those currently used. While biomolecular processors are unlikely to displace semiconductor processors for speed and accuracy, certain proteins may offer solutions to problems confronting logical processor design, including self-assembly and emergent computation. Cytoskeletal proteins may prove useful as biomolecular processors or may inspire hybrid designs. Actin filaments and microtubules, for example, have highly charged surfaces that enable them to conduct electric currents and process information. The biophysical properties of these filaments relevant to the conduction of ionic current include a condensation of counterions on the filament surface, the non-linear complex physical structure, and in the case of microtubules, nanopores that allow ions to pass between the outer environment to the microtubule lumen. Possible roles for cable-like, conductive filaments in neurons include intracellular information processing, regulation of developmental plasticity, and mediation of transport. Operating as an interconnected matrix, cytoskeletal proteins form a complex network capable of emergent information processing; moreover, they stand to intervene between inputs to and outputs from neurons. The cytoskeletal matrix receives information from the neuronal membrane and its intrinsic components (e.g., ion channels, scaffolding proteins, and adaptor proteins), especially at sites of synaptic contacts and spines, and in turn affects the output of the neuron. An information-processing model based on cytoskeletal networks is described, which may underlie certain types of learning and memory. 863 The Cytoskeleton as a Nanoscale Information Processor 3.

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Pseudo-spin model for the microtubule wall in external field

Cited by 6 publications

References 24 publications

Neural cytoskeleton capabilities for learning and memory

Neural cytoskeleton capabilities for learning and memory

Overt and covert paths for sound in the auditory system of mammals

The Cytoskeleton as a Nanoscale Information Processor: Electrical Properties and an Actin-Microtubule Network Model

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