Pseudo-Tumour of Bone in Haemophilia

Nelson, Marlene; Mitchell, Evan

doi:10.1159/000207256

Cited by 8 publications

(3 citation statements)

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“…Reported complications have primarily been life‐threatening haemorrhage and infection. Modern surgical case reviews are not available [4–6]. Surgical resection, factor replacement, radiation and laparoscopic resection with injection of fibrin glue have all been used successfully as treatment modalities.…”

Section: Discussionmentioning

confidence: 99%

Cranial Pseudotumour in Haemophilia

Libby

White

2004

Haemophilia

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Section: Discussionmentioning

confidence: 99%

Cranial Pseudotumour in Haemophilia

Libby

White

2004

Haemophilia

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“…6 The process appears to be initiated by subperiosteal bleeding, followed by calcification of the hematoma. It may not progress beyond this stage, in which case the lesion is harmless and does not require treatment.…”

Section: Commentmentioning

confidence: 99%

The Problem of Unrecognized "Mild Hemophilia"

Pappas¹,

Barr²,

Salzman³

et al. 1964

JAMA

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“…Only very few publications have reported on the aspects of muscle haematoma in patients with severe haemophilia [1,5]. Predominantly, reports have focused on the management of m. psoas major bleeds [6,7] and haemophilia pseudotumours [8–10]. As of today, limited consensus exists regarding choice of factor concentrate, dosages of factor substitution utilized, frequency of dosing, and duration of the haemostatic treatment.…”

Section: Introductionmentioning

confidence: 99%

Current practice in the management of muscle haematomas in patients with severe haemophilia

Beyer¹,

Ingerslev²,

Sørensen³

2010

Haemophilia

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Muscle haematomas (MH) represent 10-25% of all bleeds in patients with severe haemophilia. We performed a cross-sectional survey on current practice in the management of MH with participation from 22 consultants. The respondents reported 492 MH/year, corresponding an average of 25/centre, mostly associated with trauma. Iliopsoas (55%), calf (18%) and thigh (18%) bleeds were scored as most serious. Half of the respondents distinguished between contusion and strains, whereas the majority (68.2%) did not categorize bleedings as intra- or intermuscular, although 77.3% routinely used ultrasound. Half of the respondents used a standard protocol for the management of MH. Twenty of 22 (90.9%) respondents offered physiotherapy in the hospital following MH, with no clear consensus on timing and type of treatment. In a theoretical case, for a 70-kg patient with a soleus triceps haematoma, the average initial dose of factor VIII was 2730 U (range: 1750-4000) twice daily for 3-5 days. In a similar case of a patient with inhibitors, 31.8% reported first-line and only use of either recombinant factor VIIa (rFVIIa) or activated prothrombin complex concentrate (APCC), while 36.4% switched between bypassing agents. Using rFVIIa, the median dose was 100 μg/kg (range: 85-270) and with APCC, the median dose was 70 U kg(-1) (range: 50-100). The majority (68.2%) did not use antifibrinolytics. Resolution of pain (81.8% & 77.3%) was regarded as the key clinical marker of arrest of bleeding as compared with diminished swelling and improved range of motion. The survey outlines limited consensus in the management of MH in patients with haemophilia and highlights potential topics for future studies.

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Pseudo-Tumour of Bone in Haemophilia

Cited by 8 publications

References 0 publications

Cranial Pseudotumour in Haemophilia

Cranial Pseudotumour in Haemophilia

The Problem of Unrecognized "Mild Hemophilia"

Current practice in the management of muscle haematomas in patients with severe haemophilia

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