Pseudoangiomatous retinal gliosis (PARG) treated with iodine plaque in patient with chronic retinal detachment

Marquez, Marilyn A.; Fortun, Jorge A.; Iyer, Prashanth G.; Harbour, J. William; Haddock, Luis J.

doi:10.1016/j.ajoc.2022.101614

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…11,12 Uygun tedavi ile gerilemeyen veya tekrar eden yırtıklı veya eksüdatif dekolmanlarda altta yatan aktif RRAT varlığı araştırılmalıdır. 13 Kliniğimizde, RRAT olguları için tercih edilen ilk sıradaki tedavi yöntemi kriyoterapi olup, yanıt alınamaması veya progresyon izlenmesi hâlinde tedavi modalitesi değiştirilmektedir. Lezyon kalınlığının daha yüksek izlendiği vakalarda plak brakiterapi birincil veya ikincil olarak tercih edilebilir.…”

Section: Discussionunclassified

Treatment and Follow-up of Reactive Retinal Astrocytic Tumors: A Cross-Sectional Study

KOÇ¹,

KIRAĞI²,

KIRATLI³

2023

Turkiye Klinikleri J Ophthalmol

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Çalışmanın amacı, kliniğimizde son 20 yıl içinde tanı almış reaktif retinal astrositik tümör (RRAT) hastalarının takip ve tedavi sonuçlarını bildirmektir. Gereç ve Yöntemler: Kliniğimizde RRAT ile takipli 29 ardışık hastanın 30 gözüne ait veriler retrospektif olarak hasta dosyalarından elde edilmiştir. Elde edilen değişkenler demografik bilgiler, tanı anında ve takip süresi sonundaki görme keskinliği düzeyleri, eşlik eden fundus bulguları, tedavi şekli ve sayısı ile takip süresidir. Bulgular: Yirmi dokuz hastanın 16'sı (%55,2) kadın, 13'ü (%44,8) erkek idi. Ortalama yaş 36,1±22,0 yıldı. Bir (%3,4) hastada bilateral RRAT mevcuttu. Üç (%10,3) hastada ikincil RRAT tespit edildi. Yirmi dört (%80,0) göz birincil olarak kriyoterapi ile tedavi edilirken, 6 (%20,0) göz için takip uygulandı. Başlangıç görme keskinliği ortalaması 0,2±0,2 düzeyinde bulundu. Ortalama 33,5±33,3 ay takipten 30 gözde görme keskinliğindeki ortalama değişim 0,02±0,12 idi. Kriyoterapi uygulanan gözlerde ortalama kriyoterapi sayısı 2,0±1,1 (aralık: 1-5) olarak tespit edildi. Toplamda 1 (%3,3) gözde tümör tümüyle kaybolurken, 26 (%86,7) gözde stabil veya gerilemiş hastalık, 3 (%10,0) gözde ise kötüleşme izlendi. Klinik izlem uygulanan 6 gözün 6'sında ortalama 33,7±29,6 ay takip sonunda stabil hastalık veya stabil bulgular görüldü. Sonuç: RRAT'ler ortalama 4. dekadda, unilateral ve sıklıkla alt temporal kadranda izlenen tümörlerdir. Bu tümörlerde ortalama 2 seans kriyoterapi ve/veya klinik izlem anatomik kontrolü sıklıkla sağlasa da (%86,7) tümörün tümüyle gerilemesini sağlayacak metodlar ve faktörler çalışmaya açıktır.Anah tar Ke li me ler: Gözbilim; kriyoterapi ABS TRACT Objective: In this study we aim to report treatment and follow-up results of reactive retinal astrocytic tumors (RRATs) which were diagnosed at our clinic in the last 20 years. Material and Methods: Retrospectively hospital charts of 30 eyes of 29 consecutive patients were reviewed. Recorded data were demographic details, visual acuities at the time of diagnosis and at the end of follow-up, accompanying fundus findings, mode and number of treatment and follow-up time. Results: Out of 29 patients 16 (55.2%) were female, 13 (44.8%) were male. Average age at the time of diagnosis was 36.1±22.0 years. One (3.4%) patient manifested bilateral RRAT. Three (10.3%) patients had secondary RRAT. Twenty four (80.0%) eyes were primarily treated with cryotherapy while 6 (20.0%) eyes were clinically observed. The mean initial visual acuity was 0.2±0.2. Following a mean follow-up of 33.5±33.3 months, the mean change in visual acuity was 0.02±0.12. The mean number of cryotherapy in the eyes which received cryotherapy was found to be 2.0±1.1 (range: 1-5). In one (3.3%) eye the tumor disappeared completely whereas in 26 (86.7%) the disease was either stable or regressed and 3 (10.0%) eyes showed progression. In 6 of 6 eyes which were managed with observation, either stable disease or stable findings were noted at the end of mean 33.7±29.6 months of followup. Conclusion: RRATs are most commonly seen i...

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Section: Discussionunclassified

Treatment and Follow-up of Reactive Retinal Astrocytic Tumors: A Cross-Sectional Study

KOÇ¹,

KIRAĞI²,

KIRATLI³

2023

Turkiye Klinikleri J Ophthalmol

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“…7 However, in recent years, the tumor has been found to be less of vascular origin, as the current name suggests, and more of a glial or astrocytic mass. 1,5,6,8,9 Hence, a suggestion has been made to rename this lesion to "pseudoangiomatous retinal gliosis," 10 "reactive retinal astrocytic tumor," or "focal nodular gliosis," 8 but we have continued to name this lesion as VPL because it is still the most commonly used term for the tumor.…”

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confidence: 99%

Surgical outcomes of pars plana vitrectomy for intraocular complications related to vasoproliferative tumour of the retina

Jong

Jawaheer

Spiteri-Cornish

et al. 2023

Retina

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Purpose: To investigate the safety and efficacy of vitrectomy (PPV) in managing intraocular complications relating to vasoproliferative tumours of the retina (VPL). Methods: Retrospective study. 17 VPL patients who underwent vitrectomy at Sheffield Teaching Hospital NHS Trust from 2005 to 2020 were included. Patient demographics, clinical characteristics, intraoperative data and surgical outcomes were collected and evaluated. Results: The mean age was 52 years. Indications for PPV included epiretinal membrane (ERM, n=7), vitreous haemorrhage (VH, n=5), retinal detachment (RD, n=3), diagnostic (n=1) and others (n=1). After PPV, 14/17(82.4%) have stabilised vision, and 3/17(17.6%) deteriorated. Subgroup analysis of ERM peel had good outcomes with 6/7(85.7%) noticing improvement or stabilisation of symptoms, mean LogMAR visual acuity improved from 0.719[6/30]±0.267[6/12] to 0.476[6/19]±0.271[6/12]. Patients undergoing surgery for VH also had good outcomes with resolution (and no recurrence) of the haemorrhage in 3/5(60%) and 5/5(100%) with one or more surgeries respectively. Outcomes for RD surgery were LogMAR 2.126[HM]±0.301[6/12] pre-operatively and 1.185[6/95]±0.522[6/19] post-operatively, with one recurrence of retinal detachment. In the ERM group, 3 patients had adjunctive treatment for VPL intraoperatively and 4 patients had none, no difference found between the two groups in terms of outcome or complications. Tumour with thickness of ≥2mm exhibited inferior visual outcomes compared to <2mm (p<0.05). Conclusions: This is one of the largest datasets in looking at outcomes of vitrectomy for complications of VPL. PPV is effective and safe in managing VPL-related intraocular complications with good outcomes and a low rate of complications, especially for patients with ERM and VH.

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Retinal Gliovascular Proliferation Secondary to Retinoblastoma Treated With Radiotherapy

Istre-Wilz,

Ebert,

Augsburger

et al. 2024

Ophthalmic Surg Lasers Imaging Retina

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Background and Objective Retinal gliovascular proliferation (RGVP) is a benign lesion of the retina that can arise idiopathically or secondary to another disease entity. This study describes the clinical features, treatment, and outcomes of six patients with secondary RGVP associated with irradiated, regressed retinoblastoma, and distinguishes it from late local relapse of retinoblastoma. Patients and Methods In a retrospective review of available clinical records of 550 patients evaluated for retinoblastoma in a single ocular oncology practice between 1975 and 2022, seven eyes of six patients were identified as having secondary RGVP overlying a treated and regressed retinoblastoma. The clinical features, treatment, and outcomes are described. Results The median age at RGVP diagnosis was 20 years. All RGVPs were associated with a completely regressed retinoblastoma and in proximity to a calcific tumor residue or chorioretinal atrophy that remained after external beam radiotherapy (six eyes) or plaque brachytherapy (one eye). Lesions were measured between 2.8 to 12 mm in largest basal diameter and 1.3 to 4.4 mm in thickness and described as globular, raised areas with focal retinal telangiectasis often associated with overlying subretinal fluid or hemorrhage. Median time between initial retinoblastoma treatment and detection of RGVP was 20 years. Treatment was decided based on evidence of lesion growth and most often consisted of laser photocoagulation and intravitreal anti-VEGF injection. Through available follow-up of the treated lesions, all exhibited at least partial regression, while two untreated lesions remained stable, reassuring us against late local relapse of retinoblastoma. Conclusions Secondary RGVP develops occasionally in association with regressed previously irradiated retinoblastoma. This lesion must be distinguished from late local relapse of active retinoblastoma. [ Ophthalmic Surg Lasers Imaging Retina 2024;55:714–720.]

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Pseudoangiomatous retinal gliosis (PARG) treated with iodine plaque in patient with chronic retinal detachment

Cited by 3 publications

References 16 publications

Treatment and Follow-up of Reactive Retinal Astrocytic Tumors: A Cross-Sectional Study

Treatment and Follow-up of Reactive Retinal Astrocytic Tumors: A Cross-Sectional Study

Surgical outcomes of pars plana vitrectomy for intraocular complications related to vasoproliferative tumour of the retina

Retinal Gliovascular Proliferation Secondary to Retinoblastoma Treated With Radiotherapy

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