2011
DOI: 10.1016/j.ijsu.2010.09.005
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Pseudoangiomatous stromal hyperplasia (PASH): A brief review

Abstract: Pseudoangiomatous stromal hyperplasia (PASH) is a benign entity of the breast and typically found incidentally. It warrants thorough investigation in order to exclude more sinister pathology masquerading as this form of benign breast disease and can often be managed expectantly without the need for surgical intervention. We provide a brief review of the literature on PASH, discussing its clinicopathological features and management.

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Cited by 44 publications
(74 citation statements)
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“…The histological features may lead to the misdiagnosis of low-grade angiosarcoma, but the channel found in PASH are not true vascular spaces but slit-like spaces lined by myofibroblasts caused by disruption and separation of stromal collagen fibres. In these cases, immunochemistry is helpful [ 12 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The histological features may lead to the misdiagnosis of low-grade angiosarcoma, but the channel found in PASH are not true vascular spaces but slit-like spaces lined by myofibroblasts caused by disruption and separation of stromal collagen fibres. In these cases, immunochemistry is helpful [ 12 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is however also described in men with gynecomastia and in immune-suppressed patients. It may also present as a mass or nodule and it is typically solitary, circumscribed, rubbery and mobile; macroscopically it presents as a well-circumscribed fibrous mass which can be white, grey or tan in colour [ 12 , 14 ]. Because it can sometimes rapidly increase in size, PASH may be causing concern regarding a possible malignant nature of the tumour.…”
Section: Discussionmentioning
confidence: 99%
“…Particularly, in men with gynecomastia, it reportedly exists in 98% of PASH cases (Badve and Sloane 1995). Various sizes have been reported from 1 to 12 cm (Jaunoo et al 2011), with most being about 3–5 cm. The tumor in our patient with macroscopic PASH characteristics had a maximum diameter of 11 cm, but we could find no other reports of such a large tumor in a man.…”
Section: Discussionmentioning
confidence: 99%
“…The treatment is not definitively specified, but the lesion may be closely watched after verification with a core needle biopsy, if there is no clinical doubt or clinical symptoms. Otherwise tumour resection should be considered [6,7].…”
Section: Mesenchymal Stromal Hyperplasiamentioning
confidence: 99%