Pseudoangiomatous Xanthelasmoid Mastocytosis – a new histopathological entity

Salah, Lucie; Ljungberg, Otto; Svensson, Åke; Rubin, Agneta Troilius

doi:10.1111/jdv.13987

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Considering pseudoangiomatous xanthelasmoid mastocytosis, only one dermoscopic case of this rare entity was published revealing a pigment network (brown reticular lines) and yellow blots (structureless areas) [ 7 ].…”

Section: Resultsmentioning

confidence: 99%

“…According to the current World Health Organization (WHO) classification, CM is divided into three forms: maculopapular cutaneous mastocytosis (MPCM) (including clinical subtypes previously known as urticaria pigmentosa [UP] and telangiectasia macularis eruptiva perstans [TMEP]), diffuse cutaneous mastocytosis (DCM), and mastocytoma of the skin [ 5 ]. Other clinical variants of CM have been described, e.g., nodular mastocytosis, plaque-type mastocytosis, pseudoangiomatous xanthelasmoid mastocytosis, and pseudoxanthomatous localised mastocytosis, though they are no longer recognised as separate entities but as clinical subtypes of either MPCM or mastocytoma based on the number of the lesions (>5 MPCM and ≤5 mastocytoma) [ 2 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. The diagnosis of cutaneous mastocytosis is generally based on clinical assessment (presentation of cutaneous lesions, positive Darier’s sign, and symptoms arising from mediator release) in association with additional investigations, such as histopathological, immunohistochemical, and sometimes genetic assessment.…”

Section: Introductionmentioning

confidence: 99%

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Dermoscopic Features of Different Forms of Cutaneous Mastocytosis: A Systematic Review

Sławińska

Kaszuba

Lange

et al. 2022

JCM

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The term mastocytosis refers to a heterogeneous group of disorders characterised by accumulation of clonal mast cells in different organs, most commonly in the skin. Little is known about the role of dermoscopy in the diagnostics of mastocytosis. To date, no systematic review on the dermoscopic features of cutaneous mastocytosis has been performed. The aim of this study was to summarise the current knowledge in the field as well as to identify the knowledge gaps to show possible directions for further studies, based on a systematic search of PubMed, Scopus, and Web of Science databases and related references published before 3 January 2022. Dermoscopic features, type of dermoscope, polarisation mode, magnification, and number of cases were analysed. In total, 16 articles were included in this review (3 case series and 13 case reports), analysing 148 patients with different variants of cutaneous mastocytosis; all of the studies analysed had a low level of evidence (V). The main dermoscopic features of urticaria pigmentosa included brown structureless areas, brown lines arranged in a network, and linear vessels distributed in a reticular pattern, with this last finding also being typical of telangiectasia macularis eruptiva perstans. The presence of either circumscribed yellow structureless areas or diffuse yellowish background was a constant pattern of mastocytoma, while nodular, pseudoangiomatous xanthelasmoid, and plaque-type mastocytosis were typified by light-brown structureless areas and/or pigment network, though the first two variants also showed yellow/yellow-orange structureless areas. Finally, pigmented streaks of radial distribution surrounding hair follicles were described to be a pathognomonic dermoscopic feature of pseudoxanthomatous mastocytosis. Although this review shows that the various clinical forms of cutaneous mastocytosis may feature diagnostic dermoscopic clues, it also underlines the need for further investigation as several relevant data are missing, including evaluation of dermoscopic pattern according to anatomical locations or “lesion age”, studies on rare mastocytosis variants, evaluation of the prognostic role of dermoscopy in the context of systemic involvement, and comparative analyses with common clinical mimickers.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dermoscopic Features of Different Forms of Cutaneous Mastocytosis: A Systematic Review

Sławińska

Kaszuba

Lange

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…[ 1 ] Another interesting case report of a rare variant “pseudoangiomatous xanthelasmoid mastocytosis” on dermoscopy also showed a brown reticular pattern and yellow blots. [ 4 ]…”

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confidence: 99%