Pseudoanguillosporin A and B: Two New Isochromans Isolated from the Endophytic Fungus <i>Pseudoanguillospora</i> sp.

Kock, Ines; Draeger, Siegfried; Schulz, Barbara; Elsässer, Brigitta; Kurtán, Tibor; Kenéz, Ágnes; Antus, Sándor; Pescitelli, Gennaro; Salvadori, Piero; Speakman, J.B.; Rheinheimer, Joachim; Krohn, Karsten

doi:10.1002/ejoc.200801083

Cited by 48 publications

(46 citation statements)

References 40 publications

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“…Both ustilaginoidins D (20) and E (21) exhibited strong cytotoxicity on KB cells by inhibiting biosynthesis of nucleic acid and protein [2]. Ustilaginoidin A (15) also inhibited ATP synthesis in mitochondria by uncoupling oxidative phosphorylation and depressing state-3 respiration of mitochondria [55].…”

Section: Cytotoxic and Antitumor Activitymentioning

confidence: 99%

“…Isochaetochromin B 2 (6) and ustilaginoidin D (20) isolated from the sponge-derived fungus Metarhizium anisopliae mxh-99 exhibited anti-tubercular activity with MIC values of 50.0 μg/mL [16]. 8'-O-Demethylnigerone (57) and 8'-O-demethylisonigerone (58) from the marine-derived Aspergillus carbonarius also showed weak anti-tubercular activity against Mycobacterium tuberculosis H37Rv with MIC values of 43.0 and 21.5 μM, respectively [7].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…The remaining bis-naphtho-γ-pyrones produced by fungi and their bioactivities need to be further studied. In recent years, an increasing number of bis-naphtho-γ-pyrones have been isolated from endophytic fungi [3,10,20] and marine-derived fungi [7,16,23]. These fungi could be the rich sources of biologically active metabolites that are indispensable for medicinal and agricultural applications [1,[63][64][65][66].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

Tian

Sun

et al. 2014

Molecules

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Bis-naphtho-γ-pyrones are an important group of aromatic polyketides derived from fungi. They have a variety of biological activities including cytotoxic, antitumor, antimicrobial, tyrosine kinase and HIV-1 integrase inhibition properties, demonstrating their potential applications in medicine and agriculture. At least 59 bis-naphtho-γ-pyrones from fungi have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, biosynthesis, and structure, as well as their biological activities. Some considerations regarding to synthesis, production, and medicinal and agricultural applications of bis-naphtho-γ-pyrones are also discussed.

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Section: Cytotoxic and Antitumor Activitymentioning

confidence: 99%

Section: Antimicrobial Activitymentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

Tian

Sun

et al. 2014

Molecules

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“…The first alternative is isochroman pseudoanguillosporin B, showing the strong antimicrobial activity. [20] The second option is embelin, undecylcyclohexadiene substituted by hydroxy and keto groups, showing in vivo antitumor, anti-inflammatory [21] and antioxidant activity. [22][ 23] In the same algae strain, bengazole C with antitumor, antibiotic and anthelmintic properties [24] was found in the semi-polar extract.…”

Section: U-hplc/hr-ms/ms Non-target Screening and Tentative Compoundsmentioning

confidence: 99%

Bioprospecting of Turbinaria Macroalgae as a Potential Source of Health Protective Compounds

Stranska-Zachariasova

Kurniatanty

Gbelcová

et al. 2017

Chemistry & Biodiversity

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The present study aims to focus on the bioprospecting of marine macroalgae of Turbinaria species, plenteous biomass of the world ocean. Three types of solvents, i.e., H 2 O, MeOH/H 2 O (80:20, v/v) and hexane/i-PrOH (50:50, v/v), were used for extraction. Both the biological activity and the pattern of present chemicals were characterized. For the cell proliferation assay, the human embryonic kidney 293 cells, cervix/breast/pancreatic adenocarcinoma, and osteosarcoma cells were used. For the antioxidant activity determination, both intracellular assay with human embryonic kidney and cervix adenocarcinoma cells, as well as the biochemical DPPH test, were employed. To complete the information about macroalgae composition, organic compounds were characterized by the liquid chromatography coupled with high resolution tandem mass spectrometry. Attention was concentrated mainly on the lipidomic profile characterization. In spite the fact that any significant antiproliferative effect was not observed for cancer cells, both the Turbinaria species were shown to be good protectors against the oxidative stress of the noncancer cells. Most of the antioxidants were determined in the hexane/i-PrOH extract. As regards the lipids identified, most of them belonged to the triacylglycerols followed by sphingomyelins, diacylglycerols, and polar (lyso) phospholipids. Additionally to fatty acids with 14, 16 and 18 carbons, also those with odd carbon numbers were frequently present.

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“…Secalonic acid A (4) 23,24 was obtained from a culture of Setophoma terrestris (NRRL 25008) obtained as a colonist of an Aspergillus f lavus sclerotium that was buried in sandy field soil near Kilbourne, IL. Cephalochromin (5) 19,20,25,26 was obtained from a culture of Cosmospora sp. (syn.…”

mentioning

confidence: 99%