Pseudocarcinomatous Hyperplasia Associated With Hidradenoma Papilliferum

Abstract

Cutaneous pseudocarcinomatous hyperplasia is a benign proliferation that can be associated with many nontumoral and tumoral conditions. In the literature, squamous proliferations of different types have been associated with several types of adnexal adenomas. However, we found no reported case of association of hidradenoma papilliferum with pseudocarcinomatous hyperplasia. We had the opportunity of studying this type of an association in a 38-year-old man. The hidradenoma was located deep in the corion of the biopsy and the uppermost squamous epithelium showed a pseudocarcinomatous hyperplasia that focally contacted with the hidradenoma. No atypia was noted in the squamous proliferation. E-cadherin was diffusely expressed by the squamous nests, whereas p53 and Ki-67 were restricted to the basal layer. Cyclin D-1 was expressed in the parabasal layer. Immunohistochemistry of the squamous proliferation was negative for human papillomavirus.

Rare Presentation of Areolar Sebaceous Hyperplasia.

“…Recently another therapy, the isotretinoin has proven its efficacy in reducing the size of sebaceous glands [35,36]. Although it is a benign condition the search for an underlying malignant tumor is systematic [37]. Hence it is preferable that the patient has a regular monitoring of his lesion, especially in the case where there is a family history of cancer like the patient of our case.…”