Pseudocholinesterase, aspartate transaminase, alanine transaminase as markers for cervical cancer: a study in a tertiary care hospital

Abstract

Butyrylcholinesterase which is also known as pseudocholinesterase, plasma cholinesterase, BCHE or BuChE, is a non-specific cholinesterase enzyme that hydrolyses different choline esters. Primarily found in the liver, it is very similar to the neuronal ABSTRACT Background: Cervical cancer is a malignant neoplasm arising from cells originating in the cervix, almost always caused by human papillomavirus (HPV). Butyrylcholinesterase is a non-specific cholinesterase enzyme that hydrolyses different choline esters. PCHE levels were lower than the normal at all the stages of cancer cervix. The present study was attempted to find out the role of some of the biochemical markers like serum pseudocholinesterase (PCHE), serum aspartate transaminase (AST), and serum alanine transaminase (ALT), in malignancy of the uterine cervix. Methods: 60 patients aged between 30 -70 years who were having cervical cancer were included into the study and 30 healthy patients within the same age group were included as controls. 5ml of venous blood was collected from all the study participants under aseptic conditions in a plain tube. Serum Pseudocholinesterase, Serum Aspartate transaminase and Serum Alanine transaminase was estimated for all the patients in both the groups. Results: The mean value of pseudocholinesterase in cervical cancer patients was lower in the cases when compared to controls and it was statistically significant (P value 0.0005), while the mean value of serum AST and ALT were higher in cases when compared to controls and it were also statistically significant. When compared with Pearson's coefficient, the serum PChE had a significant negative correlation with AST and ALT, while the serum AST had a significant positive correlation with ALT and a negative correlation with PChE. Conclusions: Among the women with cervical cancer, it was observed that the enzyme activity of PChE was lower than normal, while that of SGPT and SGOT were higher. PCHE, AST, and ALT can be used as tumor markers in the management of malignancy of the uterine cervix.

Pre-treatment de-ritis ratio as a marker for cervical cancer: a study at regional cancer centre

“…Veeramalla V noted the mean value of serum AST and ALT to be 50.60±16.61 U/L and 50.28±15.25U/L were higher than our findings. He also compared the values with controls and found that the mean serum AST, ALT values were significantly higher in cervical cancer cases compared to controls (30.43±3.22 U/L and 34.47±4.32 U/L respectively) [8].…”

“…Thus there is excess of mitochondrial enzyme being released i.e., AST, both cytosolic and mitochondrial enzyme. Significant elevation of AST/ALT ratio in advanced stages of the disease could be probably explained as being associated with the degree of necrosis of the tumor [8]. Thus by conducting this study we could rule out the use of pre-treatment serum AST/ALT ratio as a prognostic marker in cervical cancer.…”

“…Similarly, the relevance ofde-ritis ratio in implication of all-cause mortality, a growing body of evidence indicating that liver biomarkers may comprise prognostic information for various clinical conditions without primary pathological manifestations of the liver and biological plausibility as explained by Veeramalla Vhas made us to conduct this study to elicit if the AST/ALT ratio could predict the prognosis of locally advanced cancer cervix before the initiation of treatment [3,4,8].…”

“…International Journal of Medical Research and Review Available online at: www.medresearch.in 168 | P a g e mean values of serum AST and ALT can be used as tumor markers in the management of malignancy of the uterine cervix as the meanswere higher in cervical cancer cases compared to controls [8].…”