Pseudocholinesterase in obese and hyperlipemic subjects

Cucuianu, M; Popescu, T.A.; Hărăguş, S

doi:10.1016/0009-8981(68)90351-3

Cited by 47 publications

(18 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Positive correlations between total BChE activity and total cholesterol levels have already been shown. 6,18,23 An increase in total BChE activity has already been detected in hyperthyroidism. 24,25 The negative correlation with E 2 is supported by data showing higher mean total BChE activity in men than in women in the fertile period, a difference that disappears after menopause.…”

Section: Discussionmentioning

confidence: 93%

“…BChE activity is positively correlated with subcutaneous fat 4 and with weight. [5][6][7][8][9] A positive association between BMI and the activity of the C 4/5 complex of BChE was also reported. 10 In the case of the CHE2 gene that interacts with the BCHE gene to form the C 5 complex, it was shown that CHE2 C5 þ individuals present a significantly lower mean weight 9 and a significantly lower mean BMI 11 than their CHE2 C5À controls.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

et al. 2003

View full text Add to dashboard Cite

OBJECTIVE:To investigate the association between butyrylcholinesterase (BChE) activities (total and band specific) and body mass index (BMI) in obese and nonobese individuals, considering other variables (anthropometric, biochemical and hormonal) and the leanness process. SUBJECTS: Obese (BMIZ30 kg/m 2 ; N ¼ 181) and nonobese individuals (N ¼ 265), classified according to the CHE2 locus phenotypes, with the obese patients being followed-up when submitted to a weight-loss program. MEASUREMENTS: Anthropometric (weight, height, BMI, waist, waist/hip ratioFWHR, triceps and subscapular skinfolds, percentage of body fat and arterial pressures), hormonal (insulin, estradiolFE 2 , triiodothyronineFT 3 and thyroxineFT 4 ) and biochemical (glucose, total cholesterol, HDL-C, triglycerides, uric acid, urea, creatinine, sodium, potassium and BChE activities) variables. RESULTS: Although obese CHE2 C5À individuals presented higher mean BChE activities than their CHE2 C5À controls and diminished mean activities with leanness, similar comparisons did not show any difference in the CHE2 C5 þ group. Furthermore, the mean serum potassium values of obese individuals were significantly higher in the CHE2 C5 þ than in the CHE2 C5À phenotype. The BChE activities were less related to BMI in obese CHE2 C5À individuals than in their controls. In the CHE2 C5À obese group, significant regression coefficients were found between BChE activity variables and BMI ( þ ), ethnic origin (higher in Euro-Brazilians), sex (higher in males), diastolic pressure (À), triceps skinfold ( þ ), total cholesterol ( þ ), T 3 ( þ ) and E 2 (À). The main findings in the CHE2 C5 þ obese group: mean insulin levels decreased with leanness and a significant correlation was detected between the C 5 complex activity and creatinine ( þ ), insulin (À) and WHR (À); a significantly higher frequency of weight loss occurred compared to the CHE2 C5À group. CONCLUSION: In the present study, different relations between obesity and some of the studied variables were found when CHE2 C5 þ and CHE2 C5À individuals were compared.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Plasma cholinesterase increases in obesity and in patients with normal body weight and hyperlipidaemia. There is a good statistical correlation between plasma cholinesterase and the serum cholesterol level and the logarithm of the serum triglyceride concentration [61].…”

Section: Thyroid Diseasementioning

confidence: 99%

Cholinesterase Its significance in anaesthetic practice

1997

View full text Add to dashboard Cite

SummaryPlasma cholinesterase is an enzyme which has importance to the anaesthetist primarily for its rôle in the metabolism of suxamethonium, although other anaesthetic related drugs that this enzyme metabolises are also increasingly important. In this article we review current thoughts on the function, profile and chemistry of plasma cholinesterase. Causes of variations in the activity of the enzyme are described and the basis of genetic variations is explained.

show abstract

“…Many reports based on studies of its activ ity suggested a role in lipid metabolism. Individuals with higher weight presented higher mean BChE activity [2,13,14], It was shown that subcutaneous fat and BChE activity are positively correlated [15] and that higher mean enzyme activity is presented by obese and hyperlipemic subjects when compared with normal con trols [16][17][18]. A physical association be tween BChE and lipoproteins such as LDL [19][20][21][22][23][24][25] as well as HDL and VHDL [25] has been reported.…”

Section: Introductionmentioning

confidence: 99%

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Chautard‐Freire‐Maia¹,

Primo-Parmo²,

Picheth

et al. 1991

Hum Hered

View full text Add to dashboard Cite

The relationship between the CHE2 locus of serum cholinesterase (BChE) and adult human weight was studied in a sample of 225 CHE2 C5+ individuals and 225 CHE2 C5- controls matched for sex, height, age and race. With respect to the intensity of the C₅ band staining (scored 1–6), 113 individuals had faint C₅ bands (scores 1–3) and 112 intense C₅ bands (scores 4–6). The individuals with intense CHE2 C5+ phenotype showed a significantly lower mean adult weight (64.66 ± 0.73 kg) when compared to their controls (70.59 ± 0.97 kg) and a significant reduction in weight variance (59.81 and 105.18, respectively). Individuals with faint C₅ bands, although showing a negative correlation between weight and C₅ band intensity, did not differ from their controls in mean weight.

show abstract

Pseudocholinesterase in obese and hyperlipemic subjects

Cited by 47 publications

References 16 publications

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

Cholinesterase Its significance in anaesthetic practice

The C<sub>5</sub> Isozyme of Serum Cholinesterase and Adult Weight

Contact Info

Product

Resources

About