Pseudodiverticulosis: a rare presentation of eosinophilic esophagitis

Kathi, Pradeep; Tama, Maher; Thammineni, Nikhila; Ehrinpreis, Murray N.

doi:10.1007/s12328-019-01044-z

Cited by 3 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Кроме того, эндоскопическая картина у 76% пациентов напоминает трахеевидный пищевод, характерный для ЭоЭ [55]. В единичных наблюдениях интрамуральный псевдодивертикулез пищевода сопровождается выраженной интраэпителиальной инфильтрацией эозинофилами и ЭоЭ [56,57]. Интересно, что у пациентов с сочетанием этих нозологий псевдодивертикулы обнаруживаются в средней трети пищевода, а при изолированном псевдодивертикулезе в проксимальной трети [56].…”

Section: интрамуральный псевдодивертикулез пищеводаunclassified

Clinical and morphological diagnosis of eosinophilic esophagitis

Maslenkina,

Mikhaleva,

Motylev

et al. 2023

Clin. Exp. Morphology

View full text Add to dashboard Cite

Eosinophilic esophagitis (EoE) is an immune-mediated disease that presents with dysphagia and esophageal bolus obstruction and is characterized by predominant intraepithelial eosinophilic infiltration at histology. The aim of our literature review was to delineate clinical and morphological EoE features in terms of differential diagnosis with other esophageal diseases, i.e., gastroesophageal reflux disease (GERD), inflammatory bowel diseases (IBDs), autoimmune diseases, and rare esophageal disorders. Clinical features of dysphagia and esophageal bolus obstruction and endoscopic criteria (according to EREFS) are typical of EoE. Nevertheless, eosinophilia of the esophageal mucosa is not a specific marker of mucosal injury and is not sufficient for EoE diagnosis. Therefore, eosinophilic esophagitis histological scoring system (EoEHSS) was developed. It involves assessment of intraepithelial eosinophilic infiltration, basal zone hyperplasia, eosinophilic abscesses, eosinophil surface layering, dilated intercellular spaces, surface epithelial alteration, dyskeratotic epithelial cells, and lamina propria fibrosis. Complex clinical, endoscopic, and histological evaluation allows accurate diagnosis of EoE and other causal factors of esophageal eosinophilia. Keywords: eosinophilic esophagitis, esophageal eosinophilia, gastroesophageal reflux disease, celiac disease, inflammatory bowel diseases, achalasia, atopy

show abstract

Section: интрамуральный псевдодивертикулез пищеводаunclassified

Clinical and morphological diagnosis of eosinophilic esophagitis

Maslenkina,

Mikhaleva,

Motylev

et al. 2023

Clin. Exp. Morphology

View full text Add to dashboard Cite

show abstract

“…Patients with EoE tend to have pseudodiverticulosis within the mid-to-distal esophagus, whereas patients without EoE had pseudodiverticula primarily in the proximal esophagus. Moreover, Kathi et al [98] reported an endoscopic and biopsy findings of a patient with dysphagia and gastroesophageal reflux disease who was found to have an esophageal pseudodiverticula along with EoE.…”

Section: Esophageal Intramural Pseudodiverticulosismentioning

confidence: 99%

An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications

Khan

Guo

et al. 2020

Digestion

View full text Add to dashboard Cite

Background: Eosinophilic esophagitis (EoE) is an immune-mediated clinicopathological condition characterized by esophageal infiltration with eosinophils resulting in chronic inflammation and stricture. Summary: The recent increase in the incidence of EoE and the characteristic presentation of symptoms with difficulty swallowing and food bolus impaction has raised key concerns of clinicians as well as researchers. EoE often presents with dysphagia, food impaction, nausea, regurgitation or vomiting, and decreased appetite. It is more common in males, affecting both adults and children. The causative manner of this condition is complex and multifactorial. Throughout recent years, researchers have made a significant contribution to understanding the pathogenesis of EoE, genetic background, natural history, work on allergy, and standardization in the evaluation of disease activity. There is relatively high prevalence of EoE among the population, emphasizing the importance of this disease. Key messages: Esophageal involvement with eosinophils may be manifested as isolated or with coexisting conditions and should be taken into consideration in the differential diagnosis. This study aimed to provide gastroenterologists with novel insights into the evaluation of esophageal involvement with eosinophils and to pay special attention to the etiological factors, coexisting clinical diseases, and complications.

show abstract

“…To our knowledge, only 9 confirmed cases of concomitant EoE and EIPD have been described. [2][3][4][5][6] In fact, 5 of the cases were reported in a retrospective Canadian series. 6 Patients with EoE presented with EIPD affecting the mid esophagus or distal part of the esophagus, as in the case reported.…”

Section: Concomitant Esophageal Intramural Pseudodiverticulosis and Ementioning

confidence: 99%

“…Histologic detection of EoE is affected by the site number of biopsy samples obtained. Salek et al 5 evaluated patients with established EOE and found that endoscopically normal areas or areas with lines may not demonstrate elevated eosinophil counts and that biopsy specimens in areas of exudates and furrows demonstrated higher eosinophil counts. In patients suspected of EoE, when the peak of infiltrating eosinophils is <14 eosinophils/HPF, more biopsies can help confirm the definitive diagnosis of EoE.…”

Section: Concomitant Esophageal Intramural Pseudodiverticulosis and Ementioning

confidence: 99%