2018
DOI: 10.1134/s0006297918110044
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Pseudogenes as Functionally Significant Elements of the Genome

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Cited by 51 publications
(51 citation statements)
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“…Interestingly, we found that most genes of the top 30 MDG differentially 5hmC markers were pseudogenes. The experimental data obtained during recent years indicate this understanding of the nature of pseudogenes is not entirely correct, and many pseudogenes are functionally significant elements of the genome and may play a regulatory role in the form of non-coding RNA [57][58][59]. Thus, we speculated that 5hmC regulated gene expression by regulating the production of pseudogene RNA.…”
Section: Discussionmentioning
confidence: 97%
“…Interestingly, we found that most genes of the top 30 MDG differentially 5hmC markers were pseudogenes. The experimental data obtained during recent years indicate this understanding of the nature of pseudogenes is not entirely correct, and many pseudogenes are functionally significant elements of the genome and may play a regulatory role in the form of non-coding RNA [57][58][59]. Thus, we speculated that 5hmC regulated gene expression by regulating the production of pseudogene RNA.…”
Section: Discussionmentioning
confidence: 97%
“…On the contrary, a low expression is detected in adrenal gland, colon and pituitary gland (https://amp.pharm.mssm.edu/Harmonizome/gene/ EEF1DP3). It is known that lncRNAs, as pseudogenes as well as the others ncRNAs, may modulate the gene expression both at the transcriptional level, interacting with the promotor of parental gene o other genes, and posttranscriptional level, acting as microRNA decoys and so they may play key roles in cellular biological processes (Chan and Tay, 2018;Hu et al, 2018;Kovalenko and Patrushev, 2018). Nowadays, is still unknown the exact role of EEF1DP3 in healthy tissues.…”
Section: Transcriptionmentioning
confidence: 99%
“…Pseudogenes are DNA sequences with high homology to functional genes. More than 17,000 pseudogenes have been identified in the human genome and up to 10% of them are transcribed (Kovalenko and Patrushev, 2018). Even if pseudogenes are considered as ancient genes that have lost their functions (Portin, 2002), they still participate to the regulation of their parental gene expression at both transcriptional and translational levels (Kovalenko and Patrushev, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…More than 17,000 pseudogenes have been identified in the human genome and up to 10% of them are transcribed (Kovalenko and Patrushev, 2018). Even if pseudogenes are considered as ancient genes that have lost their functions (Portin, 2002), they still participate to the regulation of their parental gene expression at both transcriptional and translational levels (Kovalenko and Patrushev, 2018). Pseudogenes can act as competing endogenous RNA (ceRNA) toward their parental gene and compete for regulatory microRNA (miRNA) (Costa et al, 2012;Kovalenko and Patrushev, 2018).…”
Section: Introductionmentioning
confidence: 99%
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