Pseudogout: An Autoimmune Paraneoplastic Manifestation of Myelodysplastic Syndrome

Iqbal, Shumaila Muhammad; Aslam, Hafiz Muhammad; Faizee, Faizan; Qadir, Sana; Waheed, Saadia

doi:10.7759/cureus.3372

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Tedeschi et al [29] and Iqbal et al [30] were the only authors to report a case of paraneoplastic arthritis mimicking pseudogout correlated with an underlying myelodysplastic syndrome. Lima et al [31] described the case of a paraneoplastic polyarthritis, polymyositis and hypercalcemia developing in a patient an acute lymphoblastic leukemia on a chronic myeloid leukemia (CML).…”

Section: Hematological Malignanciesmentioning

confidence: 99%

Paraneoplastic arthritides: an up-to-date case-based systematic review

Khayyat¹,

Conticini²,

Falsetti³

et al. 2022

Reumatologia

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Among the rheumatic diseases whose symptoms are more often associated with the possibility of cancer and other malignancies are systemic sclerosis, dermatomyositis and rheumatic polymyalgia. However, a differential diagnosis should be performed in each case of non-typical rheumatic disease and/or other neoplastic disease risk factors. The article’s aim was based on a literature review of this subject and presentation own a case description and discussion about arthritis as a paraneoplastic syndrome. The conclusions of our analysis were as follows: more often paraneoplastic arthritis occurs in men, in ages higher than 50 years old, in patients who poorly respond to treatment of arthritis with polyarticular symmetrical involvement of the limbs, seronegative type of inflammatory joint disease. In this group of patients, complete remission after treatment of the primary tumor and recurrence of the symptoms in the presence of metastasis was observed.

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Section: Hematological Malignanciesmentioning

confidence: 99%

Paraneoplastic arthritides: an up-to-date case-based systematic review

Khayyat¹,

Conticini²,

Falsetti³

et al. 2022

Reumatologia

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“…CKD was defined as present if it was included on the problem list or clinical notes within 30 days of the index date and encompassed a range of severity, and it is possible that different stages of CKD may be associated with different risks for acute CPP crystal arthritis. Recurrent acute CPP crystal arthritis has been noted in case reports of patients with myelodysplastic syndrome (MDS) and/or acute myelogenous leukemia (AML) who have not received granulocyte colony stimulating factor (the latter of which has been linked with acute CPP crystal arthritis flares) 14,15,16 . The pathophysiology linking acute CPP crystal arthritis and MDS/AML remains unclear; it is possible that systemic inflammation related to neoplasm is a triggering factor.…”

Section: Resultsmentioning

confidence: 99%

Acute Calcium Pyrophosphate Crystal Arthritis Flare Rate and Risk Factors for Recurrence

Yates

Yoshida²,

Xu³

et al. 2019

J Rheumatol

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Objective Little is known about acute calcium pyrophosphate (CPP) crystal arthritis flare rates and risk factors for recurrence. We characterized flares and determined the rate and predictors of acute CPP crystal arthritis flares in an academic medical center cohort. Methods We performed a retrospective cohort study among a random sample of patients with acute CPP crystal arthritis identified in the Partners HealthCare electronic medical record, 1991–2017. Flare was defined as self-limited, acute-onset synovitis with synovial fluid CPP crystals and/or chondrocalcinosis, not better explained by another cause. We calculated incidence rates (IR) for acute CPP crystal arthritis flare among all subjects and by sex. We estimated HR for recurrent flare using univariate Cox models that accounted for within-person correlated data. Results We identified 70 patients with acute CPP crystal arthritis with a total of 111 flares. Recurrent flares occurred in 24% of patients; half of flares occurred in a previously unaffected joint. The acute CPP crystal arthritis flare rate was 11.4 per 100 person-years overall (95% CI 8.2–15.4), 14.2 in women (95% CI 9.6–0.1), and 7.1 in men (95% CI 3.4–13.0). Cancer (HR 2.98, 95% CI 1.33–6.68) and chronic kidney disease (HR 2.92, 95% CI 1.10–7.76) were associated with a higher rate for recurrent flare. Conclusion Recurrent flares occurred in about one-fourth of patients with acute CPP crystal arthritis and often occurred in previously unaffected joints. The acute CPP crystal arthritis flare rate was twice as high in women as in men.

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“…CPPD is an idiopathic condition, however, it has a predilection to affect patients with certain risk factors. Aging, previous joint injury, osteoarthritis, hyperparathyroidism, hypermagnesemia, hypothyroidism, and hemochromatosis are some of these risk factors [4,5]. Chronic cases of CPPD may mimic rheumatoid arthritis or osteoarthritis [6].…”

Section: Discussionmentioning

confidence: 99%

A Case of Pseudogout Causing Thoracic Myelopathy

Carpenter¹,

Siddique²,

El‐Zammar³

et al. 2022

Cureus

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Calcium pyrophosphate deposition disease is not an uncommon cause of polyarthritis, especially in the elderly. This disease typically affects the appendicular skeleton but may rarely affect the axial skeleton as well. When the axial skeleton is involved, it can lead to numerous neurological signs and can be disabling. We describe a case in which a 68-year-old male presented with on-and-off myelopathy and was thought to have chronic inflammatory demyelinating polyneuropathy. Magnetic resonance imaging of the spine suggested an inflammatory or infectious lesion at the thoracic level. However, after a surgical biopsy, pathologists concluded that calcium pyrophosphate deposition, or pseudogout, was the cause of this patient's neurological symptoms. Pseudogout in the spine, especially the thoracic spine, is exceptionally rare. There are very few additional cases reported. In this report, we review the current literature on existing similar cases, radiological findings, risk factors, and treatments for this condition in hopes of increasing knowledge and awareness of this rare differential.

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Pseudogout: An Autoimmune Paraneoplastic Manifestation of Myelodysplastic Syndrome

Cited by 4 publications

References 14 publications

Paraneoplastic arthritides: an up-to-date case-based systematic review

Paraneoplastic arthritides: an up-to-date case-based systematic review

Acute Calcium Pyrophosphate Crystal Arthritis Flare Rate and Risk Factors for Recurrence

A Case of Pseudogout Causing Thoracic Myelopathy

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