Background: Hyperplastic polyps of the esophagus are rare lesions that are often associated with reflux esophagitis and hiatal hernia. They are frequently asymptomatic and discovered incidentally at endoscopy or radioimaging. Case Report: We present a 25-year-old female who had multiple nodules of the lower esophagus at endoscopy. Her major complaints were recurrent heartburn, regurgitation and epigastric pain. Sections of the biopsied esophageal nodules showed features that were consistent with hyperplastic polyp of the esophagus. Conclusion: Though the report of esophageal hyperplastic polyp from Nigeria is scarce in the literature, the rate of detection and reporting is likely to increase as gastrointestinal endoscopy services become more available and accessible in the country.