Pseudomembranous colitis within radiotherapy field following concurrent chemoradiation therapy: a case report

Shen, Bo; Lin, Shih-Chiang; Shueng, Pei‐Wei; Chou, Yueh-Hung; Tseng, Li-Ming; Hsieh, Chen‐Hsi

doi:10.2147/ott.s40145

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Despite a high prevalence of C. difficile in Asia [27,28,30,35], reports of severe outcomes of CDI are rare. Few reports of PMC and toxic megacolon exist from Asian countries [36,37,38,39,40,41,42,43], suggesting they may be less commonly seen than in other regions. Where reports do appear, they are frequently associated with infection with A-B+ strains [36,40].…”

Section: Epidemiology Of CDI In Asiamentioning

confidence: 99%

Clostridium difficile in Asia: Opportunities for One Health Management

Collins

Riley

2018

TropicalMed

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Clostridium difficile is a ubiquitous spore-forming bacterium which causes toxin-mediated diarrhoea and colitis in people whose gut microflora has been depleted by antimicrobial use, so it is a predominantly healthcare-associated disease. However, there are many One Health implications to C. difficile, given high colonisation rates in food production animals, contamination of outdoor environments by use of contaminated animal manure, increasing incidence of community-associated C. difficile infection (CDI), and demonstration of clonal groups of C. difficile shared between human clinical cases and food animals. In Asia, the epidemiology of CDI is not well understood given poor testing practices in many countries. The growing middle-class populations of Asia are presenting increasing demands for meat, thus production farming, particularly of pigs, chicken and cattle, is rapidly expanding in Asian countries. Few reports on C. difficile colonisation among production animals in Asia exist, but those that do show high prevalence rates, and possible importation of European strains of C. difficile like ribotype 078. This review summarises our current understanding of the One Health aspects of the epidemiology of CDI in Asia.

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Section: Epidemiology Of CDI In Asiamentioning

confidence: 99%

Clostridium difficile in Asia: Opportunities for One Health Management

Collins

Riley

2018

TropicalMed

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“…[33] (20,4 % против 9,5 % соответственно; р = 0,005), причём рак является независимым фактором риска реци-дива. Описаны случаи возникновения ПМК у пациентов, страдающих злокачественными новообразованиями, на фоне проведения послеоперационной химиолучевой терапии без применения антибиотиков в анамнезе [34,35].…”

Section: клиническая картинаunclassified

Pseudomembranous colitis complicated by toxic megacolon in oncological patients

Morikov,

Kartashova,

Shelekhov

et al. 2023

Acta biomedica scientifica

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In recent years, information on the increase in the incidence of infection associated with Clostridioides difficile (CDI) has appeared in the literature. It is known that C. difficile which causes pseudomembranous colitis (PMC) most often affects debilitated patients who receive treatment for the main pathology for a long time. That is why PMC is most common in cancer patients receiving long-term and aggressive anticancer treatment, which is often accompanied by the use of several courses of antibiotics. The result of the irrational use of antibiotics, incorrect PMC therapy may be the formation of toxic megacolon, intestinal perforation, sepsis, which in turn is fraught with a fatal outcome. It is this state of affairs that aroused our interest in the study of this topic. The steady increase in the incidence of Clostridioides difficile infection makes it particularly relevant to study CDI problem in relation to cancer patients, since they most often have a wide range of risk factors for developing clostridial infection. The article presents an overview of domestic and foreign sources describing this pathology, discusses epidemiology, pathogenesis, clinical picture and current understanding of the CDI treatment. At the end of the review, we present a case of successful treatment of pseudomembranous colitis after stoma closure, which was complicated by the development of toxic megacolon. Colproctectomy was performed as part of the complex treatment of this pathology. The patient received respiratory, renal replacement, hepatoprotective, antibiotic and antifungal therapy and other treatments.

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Linked mutations within the pathogenicity locus of Clostridioides difficile increase virulence

Lin,

Li,

et al. 2023

Infectious Diseases

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Pseudomembranous colitis within radiotherapy field following concurrent chemoradiation therapy: a case report

Cited by 4 publications

References 20 publications

Clostridium difficile in Asia: Opportunities for One Health Management

Clostridium difficile in Asia: Opportunities for One Health Management

Pseudomembranous colitis complicated by toxic megacolon in oncological patients

Linked mutations within the pathogenicity locus of Clostridioides difficile increase virulence

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