Pseudomembranous<i>Aspergillus</i>tracheobronchitis in a heart transplant recipient

Ramos, António; Segovia, Javier; Gómez‐Bueno, Manuel; Salas, Clara; Lázaro, María; Sánchez, I.; Pulpón, L. Alonso

doi:10.1111/j.1399-3062.2009.00444.x

Cited by 11 publications

(12 citation statements)

References 24 publications

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“…In the small series of patients with pseudomembranous Aspergillus tracheobronchitis reported by Tasci et al, one patient had elevated level of serum Aspergillus antigen, while borderline and negative results were found in two other patients, respectively [45]. Low serum Aspergillus antigen level in a heart transplant recipient with pseudomembranous Aspergillus tracheobronchitis has been recently reported by Ramos et al [75]. To explain these differences, Van Assen et al presented two hypotheses.…”

Section: Trachobronchial Aspergillosismentioning

confidence: 99%

Tracheobronchial Manifestations ofAspergillusInfections

Krenke

Grabczak

2011

The Scientific World JOURNAL

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Human lungs are constantly exposed to a large number of Aspergillus spores which are present in ambient air. These spores are usually harmless to immunocompetent subjects but can produce a symptomatic disease in patients with impaired antifungal defense. In a small percentage of patients, the trachea and bronchi may be the main or even the sole site of Aspergillus infection. The clinical entities that may develop in tracheobronchial location include saprophytic, allergic and invasive diseases. Although this review is focused on invasive Aspergillus tracheobronchial infections, some aspects of allergic and saprophytic tracheobronchial diseases are also discussed in order to present the whole spectrum of tracheobronchial aspergillosis. To be consistent with clinical practice, an approach basing on specific conditions predisposing to invasive Aspergillus tracheobronchial infections is used to present the differences in the clinical course and prognosis of these infections. Thus, invasive or potentially invasive Aspergillus airway diseases are discussed separately in three groups of patients: (1) lung transplant recipients, (2) highly immunocompromised patients with hematologic malignancies and/or patients undergoing hematopoietic stem cell transplantation, and (3) the remaining, less severely immunocompromised patients or even immunocompetent subjects.

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Section: Trachobronchial Aspergillosismentioning

confidence: 99%

Tracheobronchial Manifestations ofAspergillusInfections

Krenke

Grabczak

2011

The Scientific World JOURNAL

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“…[14]Diabetes mellitusInconsistent use of insulin Aspergillus Cough, chest pain, hoarseness, fever, dyspnealiposomal amphotericin BDeceasedRamos et al. [15]Cardiac amyloidosisHeart transplant Aspergillus Fever, dyspnea, wheezing, and a coughIV voriconazoleIV caspofunginImprovedShah et al. [16]StillbirthPulmonary edema Aspergillus Dyspnea, stridorVoriconazoleImproved, then lost to follow up…”

Section: Discussionmentioning

confidence: 99%

Pseudomembranous tracheitis caused by Aspergillus fumigatus in the setting of high grade T-cell lymphoma

Malhotra

Singh

Gill

et al. 2017

Respiratory Medicine Case Reports

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Pseudomembranous tracheitis (PMT) is a rare condition most commonly caused by fungal or bacterial infection that is characterized by a pseudomembrane that partially or completely covers the tracheobronchial tree. PMT is most commonly found in immunocompromised patient populations, such as post-chemotherapy, AIDS, post-transplant and hematological malignancies. Due to its rarity, PMT is often not included in the differential diagnosis. This case describes a 65 year old male with persistent fever and refractory cough despite high dose empiric antibiotics. Subsequent bronchoscopy with biopsy revealed pseudomembranous tracheitis due to Aspergillus fumigatus in the setting of T-cell lymphoma. PMT should be considered in the differential diagnosis of refractory cough in the immunocompromised population. However, it has been described in patients with nonspecific respiratory symptoms such as dyspnea, cough, and other airway issues.

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“…More advanced immunosuppression, mechanical ventilation delay in performing bronchoscopy, severe hemoptysis, and persistent positive culture of respiratory secretions after initiation of treatment seem to be related to an adverse prognosis [13].…”

Section: Discussionmentioning

confidence: 99%

“…Aspergillus flavus , Aspergillus niger , and Aspergillus nidulans were cultured in 4.1%, 3.3%, and 1.7%, respectively, whereas in 28% of the cases data regarding the species were not available [12]. Diagnosis of ATB may be delayed because of its insidious onset, non-specific signs and symptoms, and scarcity of radiographic abnormalities [13]. Therefore bronchoscopic evaluation should be performed in patients with high risk profile and respiratory symptoms (e.g.…”

Section: Introductionmentioning

confidence: 99%

Aspergillus tracheobronchitis, bronchopleural fistula and empyema after lobectomy for aspergilloma

Rummens

Bruyneel

Lungarella

et al. 2014

Medical Mycology Case Reports

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Aspergillus tracheobronchitis and Aspergillus empyema are two rare manifestations of Aspergillus infection. This case report presents a patient with chronic obstructive pulmonary disease who developed a pseudomembranous Aspergillus tracheobronchitis, bronchopleural fistula and empyema 16 months after lobectomy for an aspergilloma. Bronchoscopy proved to be important for assessment of severity. Combined systemic anti-fungal treatment (voriconazole) and open window thoracostomy were used to successfully treat the patient.

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PseudomembranousAspergillustracheobronchitis in a heart transplant recipient

Cited by 11 publications

References 24 publications

Tracheobronchial Manifestations ofAspergillusInfections

Tracheobronchial Manifestations ofAspergillusInfections

Pseudomembranous tracheitis caused by Aspergillus fumigatus in the setting of high grade T-cell lymphoma

Aspergillus tracheobronchitis, bronchopleural fistula and empyema after lobectomy for aspergilloma

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