Pseudomonas aeruginosa: a pathogen making itself at home

Stölting, Helen; Lloyd, Clare M.

doi:10.1016/j.it.2022.05.002

Cited by 4 publications

(1 citation statement)

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“…Pseudomonas is a type of bacteria that can cause respiratory infections and disease in individuals with weakened immune systems, such as those with cystic fibrosis, chronic obstructive pulmonary disease (COPD), or severe asthma [ 22 ]. Pseudomonas aeruginosa (P. aeruginosa ) infection represents a significant danger to individuals with cystic fibrosis (CF).…”

Section: Introductionmentioning

confidence: 99%

Restoring the epigenetic landscape of lung microbiome: potential therapeutic approach for chronic respiratory diseases

KavianFar,

Taherkhani,

Ahmadi

et al. 2024

BMC Pulm Med

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Background Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and bronchiectasis, present significant threats to global health. Recent studies have revealed the crucial role of the lung microbiome in the development of these diseases. Pathogens have evolved complex strategies to evade the immune response, with the manipulation of host cellular epigenetic mechanisms playing a pivotal role. There is existing evidence regarding the effects of Pseudomonas on epigenetic modifications and their association with pulmonary diseases. Therefore, this study aims to directly assess the connection between Pseudomonas abundance and chronic respiratory diseases. We hope that our findings will shed light on the molecular mechanisms behind lung pathogen infections. Methods We analyzed data from 366 participants, including individuals with COPD, acute exacerbations of COPD (AECOPD), bronchiectasis, and healthy individuals. Previous studies have given limited attention to the impact of Pseudomonas on these groups and their comparison with healthy individuals. Two independent datasets from different ethnic backgrounds were used for external validation. Each dataset separately analyzed bacteria at the genus level. Results The study reveals that Pseudomonas, a bacterium, was consistently found in high concentrations in all chronic lung disease datasets but it was present in very low abundance in the healthy datasets. This suggests that Pseudomonas may influence cellular mechanisms through epigenetics, contributing to the development and progression of chronic respiratory diseases. Conclusions This study emphasizes the importance of understanding the relationship between the lung microbiome, epigenetics, and the onset of chronic pulmonary disease. Enhanced recognition of molecular mechanisms and the impact of the microbiome on cellular functions, along with a better understanding of these concepts, can lead to improved diagnosis and treatment.

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Section: Introductionmentioning

confidence: 99%