Pseudomonas aeruginosa adapts its iron uptake strategies in function of the type of infections

Abstract

Pseudomonas aeruginosa is a Gram-negative γ-Proteobacterium which is known for its capacity to colonize various niches, including some invertebrate and vertebrate hosts, making it one of the most frequent bacteria causing opportunistic infections. P. aeruginosa is able to cause acute as well as chronic infections and it uses different colonization and virulence factors to do so. Infections range from septicemia, urinary infections, burn wound colonization, and chronic colonization of the lungs of cystic fibrosis patients. Like the vast majority of organisms, P. aeruginosa needs iron to sustain growth. P. aeruginosa utilizes different strategies to take up iron, depending on the type of infection it causes. Two siderophores are produced by this bacterium, pyoverdine and pyochelin, characterized by high and low affinities for iron respectively. P. aeruginosa is also able to utilize different siderophores from other microorganisms (siderophore piracy). It can also take up heme from hemoproteins via two different systems. Under microaerobic or anaerobic conditions, P. aeruginosa is also able to take up ferrous iron via its Feo system using redox-cycling phenazines. Depending on the type of infection, P. aeruginosa can therefore adapt by switching from one iron uptake system to another as we will describe in this short review.

Siderophores for molecular imaging applications

“…Yersinia pestis, Mycobacterium tuberculosis or Pseudomonas aeruginosa [e.g. 15]. As a result, siderophores were suggested as biomarkers in aspergillosis and tuberculosis [16,17].…”

Differential Contributions of the Outer Membrane Receptors PhuR and HasR to Heme Acquisition in Pseudomonas aeruginosa

“…Many pathogens including the opportunistic pathogen Pseudomonas aeruginosa encode systems that utilize the host heme containing proteins as a source of iron (5,6). P. aeruginosa encodes two heme uptake systems the Pseudomonas heme uptake (phu) 2 and the heme assimilation systems (has).…”

Rôles des sidérophores bactériens et de mammifères dans les interactions hôtes-pathogènes

“…Pour acquérir de façon efficace le fer, les bactéries ont développé différentes stratégies de capture du métal qui dépendent de sa disponibilité dans l'environnement, de sa nature (ionique, héminique), et de son degré d'oxydation [9,10]. Lorsque le fer est en quantité limitée, les bactéries produisent et sécrètent des sidérophores (du grec pherein et sideros signifiant « porter le fer »).…”