Pseudomonas aeruginosa bacteremia in patients with neoplastic disease

Fishman, Louis; Armstrong, Donald

doi:10.1002/1097-0142(197209)30:3<764::aid-cncr2820300326>3.0.co;2-g

Cited by 44 publications

(8 citation statements)

References 28 publications

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“…DISCUSSION Infections represent a serious problem in haematological patients, especially during neutropenic periods (7). Potential pathogens present in the environment could easily colonize skin and mucosae of these immunocompromised patients, caused by primary pathology as well as antineoplastic treatment (8)(9)(10). In particular, eating of uncooked vegetables and contamination from personnel and/or the environment represent common means for colonization of the gastrointestinal tract and other mucosae.…”

Section: Polyphenolssupporting

confidence: 58%

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Nosocomial outbreak of severe Pseudomonas aeruginosa infections in haematological patients

Grigis¹,

Goglio²,

Parea³

et al. 1993

Eur J Epidemiol

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From June to September 1988, an outbreak of Pseudomonas aeruginosa infections in neutropenic patients admitted to the Haematological Wards of "Ospedali Riuniti" in Bergamo, Italy, was detected. Out of 11 cases of P. aeruginosa infections, 8 were bacteremic. Of these, 7 died within few days of onset (mortality rate: 87.5%). Consequently, possible sources of infection were investigated, and moist areas of the hospital environment were shown to be highly contaminated by P. aeruginosa. A clinical and microbiological follow-up of patients admitted to the Haematological Wards was performed for a 10 month period following the outbreak. Adequate measures for cleaning and disinfection were shown to reduce the frequency of P. aeruginosa hospital infections.

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Section: Polyphenolssupporting

confidence: 58%

“…-Typing of 54 P. aeruginosa strains isolated from the environment of (46) and patients(8) admitted to Haematological Wards of "Ospedali Riuniti" in Bergamo, Italy, from June to September 1988.…”

mentioning

confidence: 99%

Nosocomial outbreak of severe Pseudomonas aeruginosa infections in haematological patients

Grigis¹,

Goglio²,

Parea³

et al. 1993

Eur J Epidemiol

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“…The paucity of similar cases in the literature suggests that P. aeruginosa persistence in lung nodules or small abscesses is unusual, but also possibly under‐recognized. Of note, P. aeruginosa bacteremia in patients with neoplastic disease has been reported to have a high recurrence rate 1.5–17 months after an initial episode . Among patients with acquired immunodeficiency syndrome and lung abscesses, 11/28 were due to P. aeruginosa , and P. aeruginosa was recovered from 4/11 recurrences, at 2–16 months after initial treatment .…”

Section: Discussionmentioning

confidence: 98%

Persistence of Pseudomonas aeruginosa in a pulmonary nodule with late relapse

Ronkainen

Xie

Battiwalla

et al. 2014

Transplant Infectious Dis

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Lung nodules are common diagnostic challenges in hematopoietic stem cell transplantation and solid organ transplantation. Pseudomonas aeruginosa is a known cause of lung abscess in these patients, but its ability to persist for months in a quiescent lung nodule and later cause recurrent infection is not well known or documented. A patient with a history of acute pre-B-cell lymphoblastic leukemia had enlargement and cavitation of a small right upper lobe pulmonary nodule 10 months after allogeneic hematopoietic stem cell transplantation. The nodule was the remnant of a presumed P. aeruginosa septic embolus that occurred 2.5 months after transplantation. With antibiotic treatment, the nodule had shrunk in size to <1 cm and remained stable. Transthoracic needle aspiration grew P. aeruginosa indistinguishable by molecular typing from isolates obtained 7.5 months earlier from blood and bronchoalveolar lavage fluid. Sub-centimeter pulmonary nodules attributable to previously treated P. aeruginosa may harbor viable organisms and lead to recrudescent infection.

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“…In the 1960s and early 1970s, aminoglycosides and polymyxins were the only options for treatment of P. aeruginosa bacteremia but were found to be fairly ineffective for these infections. Mortality of greater than 50% was reported when mortality was used as the end point (Fishman & Armstrong, 1972;Whitecar, Luna, & Bodey, 1970), and was as high as 70% in febrile neutropenic patients (Bodey, Jadeja, & Elting, 1985). Despite the introduction of effective anti-pseudomonal β-lactams and the associated reduction in mortality rates, P. aeruginosa bacteremia is still one of the most feared nosocomial infections.…”

Section: Bacteremiamentioning

confidence: 99%

Pseudomonas aeruginosa – Pathogenesis and Pathogenic Mechanisms

Alhazmi

2015

IJB

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Pseudomonas aeruginosa is a common bacterium, Gram-negative opportunistic pathogen capable of infecting humans with compromised natural defenses and causing severe pulmonary disease. It is one of the leading pathogen associated with nosocomial infections. It has a vast arsenal of pathogenicity factors that are used to interfere with host defenses. Pathogenesis in P. aeruginosa facilitates adhesion, modulate or disrupt host cell pathways, and target the extracellular matrix. The propensity of P. aeruginosa to form biofilms further protects it from antibiotics and the host immune system. P. aeruginosa is intrinsically resistant to a large number of antibiotics and can be acquired resistance to many others, making treatment difficult. P. aeruginosa provokes a potent inflammatory response during the infectious process. The majority of mortalities in immunocompromised patients; cystic fibrosis, can be attributed to the progressive decline of lung function resulting from chronic infection by pathogens such as P. aeruginosa. Antibiotic treatment of chronic P. aeruginosa infections may temporarily suppress symptoms; however, they do not eradicate the pathogen. Lung diseases caused by P. aeruginosa are a leading cause of death in immunocompromised individuals as well as in children. Although immunocytes recruitment is critical to augment the host defense, excessive neutrophil accumulation results in life-threatening diseases, such as acute lung injury, as well as acute respiratory distress syndrome. Several virulence factors have been studied for their roles as potential vaccine candidate, although there is currently no clinically accepted vaccine. Understanding host-pathogen interaction is critical for the development of effective therapeutic strategies to control the damage in the lung.

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Pseudomonas aeruginosa bacteremia in patients with neoplastic disease

Cited by 44 publications

References 28 publications

Nosocomial outbreak of severe Pseudomonas aeruginosa infections in haematological patients

Nosocomial outbreak of severe Pseudomonas aeruginosa infections in haematological patients

Persistence of Pseudomonas aeruginosa in a pulmonary nodule with late relapse

Pseudomonas aeruginosa – Pathogenesis and Pathogenic Mechanisms

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