Pseudomonas aeruginosa isolates and their antimicrobial susceptibility pattern among catheterized patients at Jimma University Teaching Hospital, Jimma, Ethiopia

Bekele, Temesgen; Tesfaye, Amene; Sewunet, Tsegaye; Waktola, Habtewold D.

doi:10.1186/s13104-015-1497-x

Cited by 18 publications

(13 citation statements)

References 14 publications

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“…The proportion of nosocomial MDR P.aeruginosa infection (4.6%) in the present study was comparable with a study in Uganda (5%) [23]. However, it was lower than findings from other parts of Ethiopia (11.1% -66.7%) [15,22,27,40], Ghana (19.5%) [32], Morocco (8%) [41], India (76.8%) [42], Thailand (9.6%) [39] and Italy (8.7%) [25]. In contrast, it was higher compared to a study in China (0.36%) [29].…”

Section: Discussionsupporting

confidence: 79%

Multi-drug resistance and nosocomial infections of Acinetobacter baumannii and Pseudomonas aeruginosa among patients hospitalized at Felegehiwot Referral Hospital, Northwest Ethiopia: A cross-sectional study

Motbinor

Mulu

Bereded

2019

Preprint

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Background:Multi-drug resistant(MDR) Acinetobacter baumannii and Pseudomonas aeruginosa are major causes of nosocomial infections globally. They are the current World Health Organization critical priority pathogens for resistance and discovery of new antibiotics. However, there is paucity of data on nosocomial infections caused by such superbugs in Ethiopia.Therfore, this study determined the magnitude and profile of nosocomial MDR Acinetobacter baumannii and Pseudomonas aeruginosa infections among patients hospitalized at Felegehiwot referral hospital, Northwest Ethiopia.Methods:A cross-sectional study was conducted at Felegehiwot referral hospital from April 1 to July 31, 2018.A total of 238 patients presumptive for blood stream, urinary tract and surgical site nosocomial infections were enrolled using convenient sampling technique.Either blood, urine and wound swab specimens were collected and processed using standard bacteriological procedures.A.baumannii and P.aeruginosa isolates were identified using standard bacteriological techniques and confirmed by automated Vitek2 Compact.Antimicrobial susceptibility testing on isolates was performed using the disk diffusion technique.The results interpreted as per the standard zone sizes of Clinical and Laboratory Standards Institute.Chi-square test was done to determine associations among variables.P.value< 0.05 was considered statistical significant. Results:The median age of participants was 29 years.Overall, 20(8.4%) of patients had nosocomial MDR A.baumannii and P.aeruginosa infections.The proportion of nosocomial MDR blood stream, urinary tract and surgical site infections were 13(8.9%),5(8.3%) and 2(6.3%), respectively. The mean age of patients with nosocomial infection was significantly lower (24.9 years) than their counter parts (29.6years) (P=0.035). All isolates of nosocomial infections were from patients with intravenous catheterization.The frequency of nosocomial MDR A.baumannii infection was 9(3.8%) and for P.aeruginosa nosocomial infections was 11(4.6%). A.baumannii and P.aeruginosa isolates were 100% MDR.MDR A.baumannii isolates were 100% resistant to ampicillin and piperacillin.MDR P.aeruginosa isolates was 100% resistant to ampicillin, piperacillin, cefotaxime and ceftriaxone.On the other hand, A.baumannii isolates showed 36.4% and 44.5% resistance against ciprofloxacin and meropenem while P.aeruginosa isolates revealed 33.3% and 45.5% resistance against Pseudomonas aeruginosa.Conclusions:Health care associated MDR A.baumannii and P.aeruginosa infections are critical problems in the study area.Therefore,urgent focused interventions required to contain the spreading of MDR NIs.Treatment of NIs for patients on health care should be guided by antimicrobial susceptibility testing.

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Section: Discussionsupporting

confidence: 79%

Multi-drug resistance and nosocomial infections of Acinetobacter baumannii and Pseudomonas aeruginosa among patients hospitalized at Felegehiwot Referral Hospital, Northwest Ethiopia: A cross-sectional study

Motbinor

Mulu

Bereded

2019

Preprint

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“…baumannii and P. aeruginosa isolates were resistant to three to six antibiotics from different classes. All isolates of A. baumannii (9) and P.aeruginosa (11) were MDR (100%). Among this, 3 (33.3%) isolates of A. baumannii and 4 (36.4%) isolates of P. aeruginosa showed resistance to antibiotics from six different classes, respectively.…”

Section: Multi-drug Resistance Profiles Of a Baumannii And P Aerugimentioning

confidence: 99%

“…Pseudomonas aeruginosa (P.aeruginosa) are usually hospital acquired and related to urinary tract catheterization or surgery [9,10]. Surgical site infection (SSI) can involve the skin, subcutaneous tissue of the incisions, deep soft tissues of the incisions and any part of organ and spaces and accounted for 17% of NIs [8,10].…”

Section: Introductionmentioning

confidence: 99%

Multi-drug resistance of blood stream, urinary tract and surgical site nosocomial infections of Acinetobacter baumannii and Pseudomonas aeruginosa among patients hospitalized at Felegehiwot Referral Hospital, Northwest Ethiopia: A cross-sectional study

Motbinor

Mulu

Bereded

2019

Preprint

View full text Add to dashboard Cite

Background: Multi-drug resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa are major causes of nosocomial infections globally. They are the current World Health Organization critical priority pathogens for resistance, AMR surveillance and discovery of new antibiotics. However, there is paucity of data on nosocomial infections (NIs) caused by such superbugs in Ethiopia. Therefore, this study determined the magnitude and profile of nosocomial MDR Acinetobacter baumannii and Pseudomonas aeruginosa infections among patients hospitalized at Felegehiwot referral hospital, Northwest Ethiopia. Methods: A cross-sectional study was conducted at Felegehiwot referral hospital from April 1 to July 31, 2018. A total of 238 patients with blood stream, urinary tract and surgical site NIs were enrolled conveniently. Either blood, urine and wound swab specimens were collected and processed using standard bacteriological procedures.A.baumannii and P.aeruginosa isolates were identified using standard bacteriological techniques and confirmed by automated Vitek2 Compact. Antimicrobial susceptibility testing on isolates was performed using the disk diffusion technique.The results interpreted as per the standard zone sizes of Clinical and Laboratory Standards Institute. Chi-square test was done to determine associations among variables. P.value < 0.05 was considered statistical significant. Results:The median age of participants was 29 years. Overall, 20 (8.4%) of patients had nosocomial MDR A.baumannii and P.aeruginosa infections.The proportion of nosocomial MDR blood stream, urinary tract and surgical site infections were 13 (8.9%), 5 (8.3%) and 2 (6.3%), respectively. Patients with NI has lower mean age (24.9 years) (P=0.035). All isolates of NIs were from patients with intravenous catheterization. The frequency of NI was 9(3.8 %) for MDR A.baumannii and 11 (4.6%) for MDR P.aeruginosa. A.baumannii and P.aeruginosa isolates were 100% MDR.All isolates of A.baumannii and P.aeruginosa were 100% resistant to ampecillin and piperacillin. A.baumannii isolates were 33.3% and 44.5% resistance against meropenem and ciprofloxacin, respectively while P.aeruginosa isolates revealed 36.4% and 45.5% resistance against ciprofloxacin and meropenem, respectively. Conclusions: Health care associated MDR A.baumannii and P.aeruginosa infections are critical problems in the study area. Therefore, urgent focused interventions required to contain the spreading of MDR NIs. Treatment of NIs for patients on health care should be guided by antimicrobial susceptibility testing.

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“…Urinary tract infection (UTI) which involves the bladder, ureter and kidney is the most common type of NIs accounting, 31% [8]. UTI caused by A. baumannii and P. aeruginosa are usually hospital acquired and related to urinary tract catheterization or surgery [9,10]. Surgical site infection (SSI) can involve the skin, subcutaneous tissue of the incisions, deep soft tissues of the incisions and any part of organ and spaces and accounted for 17% of NIs [8,10].…”

Section: Introductionmentioning

confidence: 99%

Multi-drug resistance of blood stream, urinary tract and surgical site nosocomial infections of Acinetobacter baumannii and Pseudomonas aeruginosa among patients hospitalized at Felegehiwot referral hospital, Northwest Ethiopia: a cross-sectional study

2020

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Background Multi-drug resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa are major causes of nosocomial infections globally. They are the current World Health Organization critical priority pathogens for resistance, Antimicrobial resistance (AMR) surveillance and discovery of new antibiotics. However, there is paucity of data on nosocomial infections (NIs) caused by such superbugs in Ethiopia. Therefore, this study determined the magnitude and profile of nosocomial MDR A. baumannii and P. aeruginosa infections among patients hospitalized at Felegehiwot referral hospital, Northwest Ethiopia. Methods A cross-sectional study was conducted at Felegehiwot referral hospital from April 1 to July 31, 2018. A total of 238 patients with blood stream, urinary tract and surgical site NIs were enrolled conveniently. Either blood, urine and wound swab specimens were collected and processed using standard bacteriological procedures. A. baumannii and P. aeruginosa isolates were identified using standard bacteriological techniques and confirmed by automated Vitek2 Compact. Antimicrobial susceptibility testing on isolates was performed using the disk diffusion technique. The results were interpreted as per the standard zone sizes of Clinical and Laboratory Standards Institute.Chi-square test was done to determine associations among variables. P value < 0.05 was considered statistical significant. Results The median age of participants was 29 years. Overall,20(8.4%) of patients had nosocomial MDR A. baumannii and P. aeruginosa infections. The proportion of nosocomial MDR blood stream, urinary tract and surgical site infections were 13(8.9%), 5(8.3%) and 2 (6.3%), respectively. Patients with NI had lower mean age (24.9 years) (P = 0.035). All isolates of NIs were from patients with intravenous catheterization. The frequency of NI was 9(3.8%) for MDR A. baumannii and 11(4.6%) for MDR P.aeruginosa. A. baumannii and P. aeruginosa isolates were 100% MDR. All isolates of A. baumannii and P. aeruginosa were 100% resistant to ampicillin and piperacillin.A. baumannii isolates were 33.3 and 44.5% resistance against meropenem and ciprofloxacin, respectively while P.aeruginosa isolates revealed 36.4 and 45.5% resistance against ciprofloxacin and meropenem, respectively. Conclusions Health care associated infections of MDR A.baumannii and P. aeruginosa are critical problems in the study area. Therefore, urgent focused interventions required to contain the spreading of MDR NIs. Treatment of NIs for patients on health care should be guided by antimicrobial susceptibility testing.

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Pseudomonas aeruginosa isolates and their antimicrobial susceptibility pattern among catheterized patients at Jimma University Teaching Hospital, Jimma, Ethiopia

Cited by 18 publications

References 14 publications

Multi-drug resistance and nosocomial infections of Acinetobacter baumannii and Pseudomonas aeruginosa among patients hospitalized at Felegehiwot Referral Hospital, Northwest Ethiopia: A cross-sectional study

Multi-drug resistance and nosocomial infections of Acinetobacter baumannii and Pseudomonas aeruginosa among patients hospitalized at Felegehiwot Referral Hospital, Northwest Ethiopia: A cross-sectional study

Multi-drug resistance of blood stream, urinary tract and surgical site nosocomial infections of Acinetobacter baumannii and Pseudomonas aeruginosa among patients hospitalized at Felegehiwot Referral Hospital, Northwest Ethiopia: A cross-sectional study

Multi-drug resistance of blood stream, urinary tract and surgical site nosocomial infections of Acinetobacter baumannii and Pseudomonas aeruginosa among patients hospitalized at Felegehiwot referral hospital, Northwest Ethiopia: a cross-sectional study

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