Pseudomonas aeruginosa Nonphosphorylated AlgR Induces Ribonucleotide Reductase Expression under Oxidative Stress Infectious Conditions

Rubio-Canalejas, Alba; Admella, Joana; Pedraz, Lucas; Torrents, Eduard

doi:10.1128/msystems.01005-22

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2024

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Cited by 3 publications

References 35 publications

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Oxidative stress responses in biofilms

da Cruz Nizer,

Adams,

Allison

et al. 2024

Biofilm

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Oxidative stress responses in biofilms

da Cruz Nizer,

Adams,

Allison

et al. 2024

Biofilm

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Beyond denitrification: Alginate production by mucoid Pseudomonas aeruginosa using wastewater nitrate as electron acceptor

Tao,

Zou,

Yuan

et al. 2024

Journal of Environmental Chemical Engineering

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Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms

Torrents,

Arévalo-Jaimes,

Admella

2024

Preprint

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Historical processes in community assembly, such as the arrival order of species, strongly influence their interactions causing priority effects. Candida albicans and Pseudomonas aeruginosa are frequently co-isolated from biofilm-based infections of the skin, lungs, and medical devices. Their relationship, predominantly antagonistic, involves physical and chemical interactions. However, the presence and implications of priority effects among these microorganisms remain largely unexplored. Here, we developed dual biofilms with differing inoculation times for each species and assessed the resulting microbial communities' in vitro virulence and susceptibility. Our findings showed that the inoculation order impacts biofilm composition, structure, virulence, and antimicrobial susceptibility. The first colonizer had an advantage for surface colonization. Consecutive colonization increased biofilm virulence and negated C. albicans’ protective effect on P. aeruginosa PAET1 against meropenem treatment. Finally, we propose N-acetylcysteine as an adjuvant for treating C. albicans and P. aeruginosa interkingdom infections, working independently of priority effects.

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Pseudomonas aeruginosa Nonphosphorylated AlgR Induces Ribonucleotide Reductase Expression under Oxidative Stress Infectious Conditions

Cited by 3 publications

References 35 publications

Oxidative stress responses in biofilms

Oxidative stress responses in biofilms

Beyond denitrification: Alginate production by mucoid Pseudomonas aeruginosa using wastewater nitrate as electron acceptor

Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms

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