PSEUDOMONAS | Burkholderia cocovenenans

Cox, Julian; Kartadarma, Embit; Buckle, K. A.

doi:10.1006/rwfm.1999.1296

Cited by 2 publications

(4 citation statements)

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“…Microbial pigments are receiving more attention in current research as they are widely applied as natural food colourants, fires, antimicrobial agents and cytotoxic activity (Ramesh et al ., 2019). Yellow Txn exhibits antibiotic activity against a variety of bacteria, fungi and plants and has mammalian toxicity (Latuasan and Berends, 1961; Cox et al ., 2000). This toxin is well known as a key virulence factor for bacterial grain rot of rice and wilt of many crop plants (Jeong et al ., 2003; Kim et al ., 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Toxoflavin (Txn) is a bright yellow pigment {1,6dimethylpyrimido[5,4-e]-1, 2,4-triazine-5,7(1H,6H) dione; molecular weight= 193}, which exhibits antibacterial, antifungal and herbicidal activities and is toxic to animals (Latuasan and Berends, 1961;Sato et al, 1989;Iiyama et al,1995;Cox et al, 2000;Nagamatsu, 2001;Kim et al, 2004). Several bacterial strains are known as Txn producers, including Burkholderia cocovenenans, B. gladioli, B. glumae, B. plantarii, Pseudomonas protegens and Streptomyces spp.…”

Section: Introductionmentioning

confidence: 99%

“…(Levenberg and Linton, 1966;Lynch and Dennis, 2010;Machlowitz et al, 1954;Philmus et al, 2015). It has been reported that B. cocovenenans intoxication caused by two toxins, bongkrekic acid and Txn, produced an average of 288 poisonings and 34 deaths in Indonesia between 1951and 1975(Latuasan and Berends, 1961Cox et al, 2000). The mode of action of Txn toxicity has been proposed: briefly, under aerobic and visible light conditions, Txn functions as an active electron carrier that is reduced and transfers its electrons to oxygen, resulting in the production of hydrogen peroxide (Latuasan and Berends, 1961).…”

Section: Introductionmentioning

confidence: 99%

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A novel toxoflavin‐quenching regulation in bacteria and its application to resistance cultivars

Choi

Lee

Park

et al. 2021

Microbial Biotechnology

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The toxoflavin (Txn), broad host range phytotoxin produced by a variety of bacteria, including Burkholderia glumae, is a key pathogenicity factor of B. glumae in rice and field crops. Two bacteria exhibiting Txn-degrading activity were isolated from healthy rice seeds and identified as Sphingomonas adhaesiva and Agrobacterium sp. respectively. The genes stdR and stdA, encoding proteins responsible for Txn degradation of both bacterial isolates, were identical, indicating that horizontal gene transfer occurred between microbial communities in the same ecosystem. We identified a novel Txnquenching regulation of bacteria, demonstrating that the LysR-type transcriptional regulator (LTTR) StdR induces the expression of the stdA, which encodes a Txn-degrading enzyme, in the presence of Txn as a coinducer. Here we show that the bacterial StdR Txn -quenching regulatory system mimics the ToxR Txn -mediated biosynthetic regulation of B. glumae. Substrate specificity investigations revealed that Txn is the only coinducer of StdR and that StdA has a high degree of specificity for Txn. Rice plants expressing StdA showed Txn resistance. Collectively, bacteria mimic the mechanism of Txn biosynthesis regulation, employ it in the development of a Txn-quenching regulatory system and share it with neighbouring bacteria for survival in rice environments full of Txn.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A novel toxoflavin‐quenching regulation in bacteria and its application to resistance cultivars

Choi

Lee

Park

et al. 2021

Microbial Biotechnology

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“…Considering the structural conservativity of mitochondrial ADP/ATP carrier in eukaryotic organisms, the toxicity of BKA is most likely universal across human and mammalian species. Previous research showed that BKA-contaminated diet can lead to the death of mice, dogs, and rhesus monkeys within 35 h [14,15]. Studies on oral administration have indicated LD50 value ranges of 1-3.16 mg/kg for human and 0.68-6.84 mg/kg for mice, respectively, while another study revealed that rats were able to survive an oral dose of 10 mg/kg of BKA, whereas a dose of 20 mg/kg was proved to be lethal [3,16].…”

Section: Introductionmentioning

confidence: 99%

Bongkrekic Acid and Burkholderia gladioli pathovar cocovenenans: Formidable Foe and Ascending Threat to Food Safety

Han,

Chen,

Chen

et al. 2023

Foods

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Bongkrekic acid (BKA) poisoning, induced by the contamination of Burkholderia gladioli pathovar cocovenenans, has a long-standing history of causing severe outbreaks of foodborne illness. In recent years, it has emerged as a lethal food safety concern, presenting significant challenges to public health. This review article highlights the recent incidents of BKA poisoning and current research discoveries on the pathogenicity of B. gladioli pv. cocovenenans and underlying biochemical mechanisms for BKA synthesis. Moreover, the characterization of B. gladioli pv. cocovenenans and the identification of the bon gene cluster provide a crucial foundation for developing targeted interventions to prevent BKA accumulation in food matrices. The prevalence of the bon gene cluster, which is the determining factor distinguishing B. gladioli pv. cocovenenans from non-pathogenic B. gladioli strains, has been identified in 15% of documented B. gladioli genomes worldwide. This finding suggests that BKA poisoning has the potential to evolve into a more prevalent threat. Although limited, previous research has proved that B. gladioli pv. cocovenenans is capable of producing BKA in diverse environments, emphasizing the possible food safety hazards associated with BKA poisoning. Also, advancements in detection methods of both BKA and B. gladioli pv. cocovenenans hold great promise for mitigating the impact of this foodborne disease. Future studies focusing on reducing the threat raised by this vicious foe is of paramount importance to public health.

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PSEUDOMONAS | Burkholderia cocovenenans

Cited by 2 publications

References 0 publications

A novel toxoflavin‐quenching regulation in bacteria and its application to resistance cultivars

A novel toxoflavin‐quenching regulation in bacteria and its application to resistance cultivars

Bongkrekic Acid and Burkholderia gladioli pathovar cocovenenans: Formidable Foe and Ascending Threat to Food Safety

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