Pseudomonas burn wound sepsis. I

Teplitz, Carl; Davis, Donald W.; Mason, Arthur D.; Moncrief, John A.

doi:10.1016/s0022-4804(64)80026-3

Cited by 141 publications

(18 citation statements)

References 4 publications

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“…This culture is used for species identification and antibacterial sensitivities. AS shown by Teplitz et al (1964), this should also be a tissue specimen and not simply a swab culture. Our main interest with species identification has centered on the presence or absence of the B-hemolytic streptococcus.…”

Section: Discussionmentioning

confidence: 99%

Delayed wound closures based on bacterial counts

Robson

Heggers

1970

Journal of Surgical Oncology

138

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There exists a quantitative relationship between bacterial contamination and clinical infection. Because of this relationship, delayed wound closure can be performed based on the number of viable bacteria present in the incision a t the time of closure. This principle was applied to 95 delayed wound closures in a prospective series. Ninetythree cases were closed when the bacterial estimate was l o 5 bacteria or fewer per gram of tissue. This resulted in a 96% successful closure rate. The method of bacterial quantification on a tissue biopsy from the wound requires 1 hr from time of culture to quantitative report to the surgeon so that closure can be effected.

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Section: Discussionmentioning

confidence: 99%

Delayed wound closures based on bacterial counts

Robson

Heggers

1970

Journal of Surgical Oncology

138

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“…Damage to this barrier following a burn disrupts the innate immune system and increases susceptibility to bacterial infection [61]. Burn wound infection was defined in a rat model with Pseudomonas aeruginosa [62, 63], in which the following progression was observed: burn wound colonization; invasion into subjacent tissue within 5 days; destruction of granulation tissue; visceral hematogenous lesions; and leukopenia, hypothermia, and death. Burn patients are at high risk for infection [64], especially drug-resistant infection [65], which often results in significantly longer hospital stays, delayed wound healing, higher costs, and higher mortality [66].…”

Section: Optimization Of Burn Wound Healingmentioning

confidence: 99%

Burn wound healing and treatment: review and advancements

et al. 2015

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Burns are a prevalent and burdensome critical care problem. The priorities of specialized facilities focus on stabilizing the patient, preventing infection, and optimizing functional recovery. Research on burns has generated sustained interest over the past few decades, and several important advancements have resulted in more effective patient stabilization and decreased mortality, especially among young patients and those with burns of intermediate extent. However, for the intensivist, challenges often exist that complicate patient support and stabilization. Furthermore, burn wounds are complex and can present unique difficulties that require late intervention or life-long rehabilitation. In addition to improvements in patient stabilization and care, research in burn wound care has yielded advancements that will continue to improve functional recovery. This article reviews recent advancements in the care of burn patients with a focus on the pathophysiology and treatment of burn wounds.

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“…What is more serious is that pathogens can easily invade adjacent healthy tissues and spread to the bloodstream in patients with severe burns who have lost normal immune function, leading to a lifethreatening infection, sepsis. 4 The treatment of wound infection in burn patients has always been one of the most intractable problems, since heavy antibiotic use has greatly increased antibiotic resistance. 5 Therefore, ideal agents against biomaterial-associated infection and burn wound infection that are effective, can operate against a wide spectrum of pathogens, and are safe are greatly needed, including inorganic antimicrobials.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial effect of gallium nitrate against bacteria encountered in burn wound infections

Zhao

Chen

et al. 2017

RSC Adv.

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Recently, biomaterials have been increasingly used for burn wound healing, but burn wound infections and biomaterial-associated infections still need to be addressed. As a novel inorganic antimicrobial, the antimicrobial effect of gallium nitrate was investigated, and the minimum inhibitory concentration (MIC) of gallium nitrate against bacteria that are common in infected burn wounds was determined with a Microbial Viability Assay Kit-WST. The results showed that the MIC of Ga(NO 3 ) 3 against E. coli and E.faecalis was 256 mg mL À1, and it was 512 mg mL À1 against P. aeruginosa, K. pneumonia, E. cloacae, A.baumannii, S. maltophilia, S. aureus and S. epidermidis. Meanwhile, transmission electron microscopy (TEM) found similar visual evidence of the mechanism by which the gallium ion attacks both Gramnegative and Gram-positive bacteria, which was in agreement with the MIC results. By TEM observation, it was found that detachment of the cell membrane and wall and the appearance of an electron-light region containing condensed substances occurred in both Ga 3+ -treated E. coli and Ga 3+ -treated S.aureus cells, with smaller morphological changes in Ga 3+ -treated S. aureus compared with E. coli. This research shows the effective and wide-spectrum antimicrobial properties of gallium nitrate against most bacteria encountered in burn wound infections. Gallium(III) could be a good choice when fighting an infected burn wound, and it is a promising candidate for modifying biomaterials or medical devices to prevent infection in burn wounds.

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Pseudomonas burn wound sepsis. I

Cited by 141 publications

References 4 publications

Delayed wound closures based on bacterial counts

Delayed wound closures based on bacterial counts

Burn wound healing and treatment: review and advancements

Antimicrobial effect of gallium nitrate against bacteria encountered in burn wound infections

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