Pseudomyxoma peritonei in women: A clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumors of low malignant potential

Mucinous epithelial neoplasms of the appendix and pseudomyxoma peritonei

“…Is a low-grade cystic appendiceal mucinous tumor that ruptures and disseminates to the peritoneum a ruptured 'adenoma'? Several authorities, [5][6][7][8][9][10] noting that the epithelium in the peritoneal metastasis is remarkably bland and that the tumor in the appendix shares features with an appendiceal adenoma, accepted that adenomatous epitheliumbeing neoplastic-might disseminate in the peritoneal cavity if given access to the peritoneum. Morphologic assessments also noted that these low-grade tumors are often associated with diverticula, herniations, dissection, or frank rupture, any of which could provide a route by which neoplastic epithelium disseminates to the peritoneum.…”

“…Other organs may be affected such as small or large bowel, liver, or ovary. 10,65 Non-mucinous appendiceal adenocarcinomas show a range of morphologic features of the invasive component. The tumors may resemble colonic adenocarcinomas with malignant glands lined by columnar cells with central dirty necrosis (Figure 11).…”

“…8,57,58,61,62,68,69 Patients with peritoneal carcinomatosis have a poor prognosis. 10,52,60,62 Treatment Invasive adenocarcinoma of the appendix warrants treatment by right hemicolectomy, with lymph node dissection, in order to stage the tumor and ensure complete resection. 57,59,62,68 Some authorities Figure 11 Invasive adenocarcinoma of the appendix.…”

“…10 Classical PMP, which occurs in patients with LAMN, demonstrates abundant mucin, hyalinized, fibrotic stroma, and occasional strips of low-grade mucinous epithelium (Figures 12 and 13). Peritoneal mucinous tumors with high-grade cytologic atypia of the neoplastic epithelium and more complex architecture are usually associated with mucinous adenocarcinomas of the appendix or elsewhere (Figure 14).…”

“The Jelly Belly”: Diagnostic Dilemmas and Current Concepts

“…PMP is a clinical terminology rather than a pathological diagnosis. The primary neoplasms producing PMP may be benign or malignant and their origin has been debated, until recent studies have attributed it to primary appendiceal mucinous neoplasms [2][3][4]. It may also originate from other mucinous neoplasms throughout the gastrointestinal tract [5].…”