Pseudophakic cystoid macular edema treated with high-dose intravenous methylprednisolone

Abstract

High-dose methylprednisolone may be effective in the treatment of pseudophakic CME.

Monthly OCT monitoring of Ozurdex for macular oedema related to retinal vascular diseases: re-treatment strategy (OCTOME Report 1)

“…Chronic or severe MO may lead to temporary or permanent visual loss depending on the degree of strain or disruption of the microscopic intraretinal neural connections (transmission defects) and the intracellular damage suffered by the visual elements (transduction defects). 1 Steroids inhibit the formation of both prostaglandins and leukotrienes and decrease intracellular and extracellular oedema by suppression of macrophage activity, vasoconstrictive effect, reduction of lymphokine production, 2 and downregulation of production of vascular endothelial growth factor (VEGF). 3 Several randomized clinical trials have reported good short-term efficacy data on intravitreal triamcinolone acetonide both in terms of improving visual acuity and reducing central retinal thickness (CRT) in patients with MO because of various retinal vascular diseases.…”

Primary intravitreal bevacizumab for the management of pseudophakic cystoid macular edema

“…8 Systemic corticosteroids are rarely prescribed as the systemic side effects are numerous. 2,8,9 Topical corticosteroids, although effective in suppressing postoperative inflammation, have many well-documented undesirable side effects including increased IOP, posterior subcapsular cataract, exacerbation of infections, and recurrence of herpetic keratitis. 2,4,8 More recently, intravitreal injection of triamcinolone acetonide has been reported as treatment for CME associated with central retinal vein obstruction and birdshot chorioretinopathy.…”

Is it time for a new attitude to "simultaneous" bilateral cataract surgery?

“…Despite this, no significant difference in mean cell loss after phacoemulsification has been found between 1% sodium hyaluronate (Healon), 1.4% sodium hyaluronate (Healon GV), 4% sodium chondroitin sulphate-3% sodium hyaluronate (Viscoat) and 2% hydroxypropyl methylcellulose (Hymecel) 80. Although we exclude patients with endothelial dystrophies or significant guttata, even corneas that appear normal preoperatively may fail postoperatively 78. The time over which this occurs is variable; thus, a short interval between cataract surgeries may not eliminate the risk.…”

“…Bilateral penetrating keratoplasty was performed, unfortunately the graft failed in one eye, the subsequent vision was 1/60, the successful graft achieved 6/36. No mention of ocular comorbidity was made 78. Improved phacoemulsification machines and techniques allow cataracts to be removed with less and less energy.…”