Pseudorabies virus infection in hunting dogs in Oita, Japan: Report from a          prefecture free from Aujeszky’s disease in domestic pigs

Kaneko, Chiho; Kaneko, Yasuyuki; Sudaryatma, Putu Eka; Mekata, Hirohisa; Kirino, Yumi; Yamaguchi, Ryoji; Okabayashi, Tamaki

doi:10.1292/jvms.20-0450

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…Together with the study by Kotnik et al [41], the present study is only the second report of PRV infection in dogs from Slovenia in over 30 years. All cases indicate direct interspecies transmission, similar to previously published results from other countries [10,15,23,24,[26][27][28][29][30][31][32][33]37], confrming the still existing risk of PR and supporting the need for national control programmes in the wild boar population for this disease.…”

Section: Discussionsupporting

confidence: 86%

“…Two studies published in 2005 and 2014 on serological surveys in Slovenian wild boar showed that PRV circulates with a prevalence of 26% to 45.1% and poses a risk to other susceptible hosts [20,22]. PRV infections in dogs have been previously reported in Europe, the United States, Japan, and China [6,10,[23][24][25][26][27][28][29][30][31][32][33]. In most cases where PRV has been reported in dogs, the dogs became infected directly by ingestion or indirectly by inhalation, or via small wounds from contact with infected pigs [1].…”

Section: Introductionmentioning

confidence: 99%

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Detection of Pseudorabies in Dogs in Slovenia between 2006 and 2020: From Clinical and Diagnostic Features to Molecular Epidemiology

Černe

Hostnik

Toplak

et al. 2023

Transboundary and Emerging Diseases

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Pseudorabies (PR) is one of the most economically important diseases in domestic pigs. Since 2010, Slovenia has been free of PR in the domestic pig population, but the disease is endemic in the wild boar population, which can pose a real threat to domestic pigs and other animal species, including dogs. Between 2006 and 2020, infections with the PR virus (PRV) were reported in two pets and three hunting dogs from Slovenia that were found to have a direct contact with the wild boar or raw wild boar or pork meat. Typical clinical signs of PRV infection, including characteristic facial itching, cytopathic effect in cell cultures, positive immunocytochemistry, and positive PCR results confirmed the presence of PRV in all five cases investigated. A phylogenetic comparison of the partial glycoprotein C (gC) genomic region revealed that the Slovenian PRV isolates belong to clade A, with 95.78–100% nucleotide identity with strains isolated from dogs, domestic pigs, and wild boars from Europe. Within phylogenetic comparison of the partial glycoprotein D (gD) and partial glycoprotein E (gE) genomic regions of Slovenian PRV isolates, 100% and 99.12%–100% nucleotide identities were detected, respectively, suggesting low diversity between the PRV strains identified in dogs in Slovenia. This study provides the first molecular characterization of PRV in dogs and suggests that similar PRV strains circulate in the wild boar populations in this geographic area.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Detection of Pseudorabies in Dogs in Slovenia between 2006 and 2020: From Clinical and Diagnostic Features to Molecular Epidemiology

Černe

Hostnik

Toplak

et al. 2023

Transboundary and Emerging Diseases

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show abstract

“…Because of the recent incidents of PRV infecting people, the dog in PRV infection has aroused great concern. PRV is prevalent in dogs, including working and hunting dogs, in the USA [ 17 , 89 , 90 ], Belgium [ 91 ], Italy [ 19 , 75 , 92 ], France [ 93 ], Spain [ 85 , 94 ], Japan [ 95 , 96 ], Austria [ 97 , 98 , 99 ], China [ 18 ], Serbia [ 100 ], Argentina [ 101 ], and Germany [ 74 ], with infection via direct or indirect contact with wild boars and pigs [ 6 , 74 ]. Dogs with PRV infection display neurological signs, anorexia, intense muzzle itch, and respiratory distress [ 1 , 96 ], and usually die within 48 h of clinical symptom onset [ 19 ].…”

Section: Prv Infection In Wild Domestic and Farm Animalsmentioning

confidence: 99%

Pseudorabies Virus Associations in Wild Animals: Review of Potential Reservoirs for Cross-Host Transmission

Liu

Tong

Zhao

et al. 2022

Viruses

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Pseudorabies virus (PRV) has received widespread attention for its potential health effects on humans, wildlife, domestic animals, and livestock. In this review, we focus on PRV dynamics in wildlife, given the importance of wild-origin PRV transmission to domestic and farm animals. Wild boars, pigs, and raccoons can serve as reservoirs of PRV, with viral transmission to domestic livestock occurring via several routes, such as wild herd exposure, contaminated meat consumption, and insect vector transmission. Many endangered feline and canine species can be infected with PRV, with acute disease and death within 48 h. The first confirmed human case of PRV infection in mainland China was reported in 2017. Thus, PRV exhibits potentially dangerous cross-host transmission, which is likely associated with inappropriate vaccination, poor awareness, and insufficient biosecurity. Currently, no vaccine provides full protection against PRV in all animals. Here, we summarize the epidemiology and pathogenesis of PRV infection in wild, domestic, and farmed animals, which may facilitate the design of novel therapeutics and strategies for controlling PRV infection and improving wildlife protection in China.

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“…It consists of a unique long region (U L ), a unique short region (U S ), internal repetitive sequences (IRS), and terminal repetitive sequences (TRS) [ 2 ]. The natural host of PRV is pigs, but it can infect most mammals, including cattle, sheep, cats, dogs, mink, and rodents [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. There are significant differences in PRV infection between natural and non-natural hosts [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Latency-Associated Transcripts in the Latent Infection of Pseudorabies Virus

Deng

Liu

et al. 2022

Viruses

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Pseudorabies virus (PRV) can cause neurological, respiratory, and reproductive diseases in pigs and establish lifelong latent infection in the peripheral nervous system (PNS). Latent infection is a typical feature of PRV, which brings great difficulties to the prevention, control, and eradication of pseudorabies. The integral mechanism of latent infection is still unclear. Latency-associated transcripts (LAT) gene is the only transcriptional region during latent infection of PRV which plays the key role in regulating viral latent infection and inhibiting apoptosis. Here, we review the characteristics of PRV latent infection and the transcriptional characteristics of the LAT gene. We also analyzed the function of non-coding RNA (ncRNA) produced by the LAT gene and its importance in latent infection. Furthermore, we provided possible strategies to solve the problem of latent infection of virulent PRV strains in the host. In short, the detailed mechanism of PRV latent infection needs to be further studied and elucidated.

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Pseudorabies virus infection in hunting dogs in Oita, Japan: Report from a prefecture free from Aujeszky’s disease in domestic pigs

Cited by 13 publications

References 31 publications

Detection of Pseudorabies in Dogs in Slovenia between 2006 and 2020: From Clinical and Diagnostic Features to Molecular Epidemiology

Detection of Pseudorabies in Dogs in Slovenia between 2006 and 2020: From Clinical and Diagnostic Features to Molecular Epidemiology

Pseudorabies Virus Associations in Wild Animals: Review of Potential Reservoirs for Cross-Host Transmission

The Role of Latency-Associated Transcripts in the Latent Infection of Pseudorabies Virus

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