Pseudosarcoma of the oesophagus

Shields, Thomas W.; Eilert, John B.; Battifora, Hector

doi:10.1136/thx.27.4.472

Cited by 42 publications

(9 citation statements)

References 8 publications

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“…Lane's concept held sway for a number of years, but with the advent of electron microscopy different views began to appear. Most reports of the ultrastructure of the spindle cells have indicated that they have desmosomes and tonofilaments and are therefore squamous in type (Lichtiger et al 1970, Shields et at. 1972, Woyke et al 1974.…”

Section: Discussionmentioning

confidence: 99%

“…The histogenesis of the spindle cell element has been the subject of much speculation over the past 80 years, the currently fashionable view being that the spindle cells are merely squamous carcinoma cells of altered morphology. Ultrastructural studies have mainly tended to confirm this concept (Lichtiger, Mackay & Tessmer 1970, Shields, Ailbert & Battifora 1972, Woyke et a / . 1974, Feldman & Barr 1976) but there has not been absolute consistency in the electron microscopic findings and some workers have found evidence favouring the older idea that the spindle cells are stromal in type (Goellner, Devine & Weiland 1973, Liefer et al The purpose of this study is to present further data on the ultrastructure of the spindle cell element of such tumours.…”

Section: Introductionmentioning

confidence: 99%

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Spindle cell squamous carcinoma: ultrastructural observations

Harris

1982

Histopathology

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Two spindle cell carcinomas of the skin and one of the breast have been studied by electron microscopy. In one tumour the spindle cells were of purely mesenchymal type and in the other two the spindle cells exhibited both mesenchymal and epithelial features within the same cells. The significance of the findings in relation to the histogenesis of the spindle cells is discussed, with special reference to the possible alternative roles of mesenchymal metaplasia of the epithelial component and spontaneous cell fusion between carcinoma cells and stromal cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spindle cell squamous carcinoma: ultrastructural observations

Harris

1982

Histopathology

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“…These light and electron microscopic findings have led many to consider that most of so-called carcinosarcomas and pseudosarcomas of the esophagus are in reality squamous carcinomas with highly morphologic variations giving a spindle sarcoma-like appearance, since the influential ultrastructural study of SHIELDS et al in 1972. 20 Thus, establishing a diagnosis of true carcinosarcoma requires a critical evaluation of the qualifying criteria, namely, the presence and admixture of a carcinoma and a genuine sarcoma, regardless of its exact histogenesis.…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma Of The Esophagus With Osseous And Cartilagenous Production A Combined Study Of Keratin Immunohistochemistry And Electron Microscopy

Hanada

Nakano

Yamashita

1984

Acta Pathologica Japonica

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A case of polypoid carcinosarcoma of the esophagus is presented. Histologically the bulk of the tumor consisted of a sarcomatous tissue having large foci of osseous and cartilagenous differentiation and infiltrating deeply the wall, whereas a superficially, invasive squamous cell carcinoma associated with insitu carcinoma was located at the base and luminal surface of the polypoid tumor. Intermingling of the carcinomatous and sarcomatous elements was found only in areas where they appeared to be collided. Ultrastructurally the sarcomatous portion contained cells with fibroblastic features but with no typical epithelial characteristics. Immunoperoxidase staining of the paraffinembedded histologic sections for keratin proteins revealed, however, some positive spindle cells indicative of epithelial nature in the sarcomatous area, but the great majority of the sarcoma cells were devoid of keratin. These combined findings strongly suggest that the sarcomatous component in our case of true carcinosarcoma is derived from mesenchymal transformation (metaplasia) of the squamous carcinoma cells. The findings were discussed in light of the previous pertinent literature. ACTA PATHOL, JPN. 34: 669–678, 1984.

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“…The exact identity of the spindle cells is also controversial, an issue wliich has not been settled by electron microscopic studies. Thus, the finding of tonofilaments, desmosomes and keratohyaline granules (Lichtiger et al 1970, Shields et al 1972, Someren et al 1976 suggests that some lesions are spindle cell epidermoid carcinomas. On the other hand, areas resembling fibroblastic osteogenic sarcoma have been described in a metastatic lesion harboring osteoid and chondroid foci (Leifer et al 1974).…”

Section: Discussionmentioning

confidence: 99%