Pseudosarcomatous Reticulohistiocytoma

Gordon, Herschel W.

doi:10.1001/archderm.1964.01600030069015

Cited by 32 publications

(11 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…known to metastasize (Levan, Hirsch & Kwong, 1963). A peculiar feature of pseudosarcomatous dermatofibroma is its association with degenerate collagen (Kempson & McGavran, 1964), and this was also conspicuous in our case. Local recurrence is explained by the fact that the tumour is not encapsulated or well defined in its limits (Stout i960), thus making complete removal uncertain.…”

Section: Histologysupporting

confidence: 74%

“…i) was suggestive of a degenerative process which was affecting the collagen. DISCUSSION Pseudosarcomatous dermatofibroma (pseudosarcomatous reticulohistiocytoma: Gordon, 1964), atypical fibroxanthoma (Reed & O'Quinn, 1971), or the nodular pseudosarcomatous fasciitis which occurs in subcutaneous tissue, is a rare condition showing multinucleated giant cells and proliferation of elongated sarcoma-like fibroblasts.…”

Section: Histologymentioning

confidence: 99%

See 1 more Smart Citation

Pseudosarcomatous dermatofibroma

THAVABALAN

Ratnaike

2006

British Journal of Dermatology

View full text Add to dashboard Cite

A pseudosarcomatous dermatofibroma with marked collagen damage is reported. The multinucleated giant cells and proliferation of very elongated sarcomatous-likc fibroblasts histologically resemble a highly mahgnant sarcoma. CASE REPORTA married white female aged 28 presented with a small flat papule in the floor of the left axilla which had been present for 5 years. She complained that it had been occasionally painful and it had slowly increased in size.On examination the lesion was a small, round, firm dermal nodule about i cm in diameter. It was removed under local anaesthesia, and sent for histological examination. HistologyThe epidermis and superfiicial dermis were essentially normal. The cellular proliferation was present in an ill-defined but localized area of the mid-and lower dermis; it did not penetrate into the subcutaneous tissue. There were numerous spindle and stellate cells together with many multinucleated giant cells scattered throughout the affected dermis. Only a few mitotic figures were seen and the nuclei were not grossly pyknotic. The collagen surrounding this cellular proliferation was abnormal in that it appeared hazy and there was coagulation and loss of the usual flbrillar structure seen in fixed and processed preparations. This abnormal dermis at the periphery of the cellular lesion ( Fig. i) was suggestive of a degenerative process which was affecting the collagen. DISCUSSION

show abstract

Section: Histologysupporting

confidence: 74%

Section: Histologymentioning

confidence: 99%

Pseudosarcomatous dermatofibroma

THAVABALAN

Ratnaike

2006

British Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…With respect to our examples of AFX, vascular invasion seems to be strongly suggestive of impending metastasis. This is particularly true in view of the fact that vascular invasion was not described in several reported cases of AFX.2-8*'y- 23 Tumor necrosis was present in the four lesions that showed vascular invasion, but was absent in the other four cases. Vascular insufficiency after the occlusion or destruction of a vessel is the most plausible explanation for the apparent relationship.…”

Section: Discussionmentioning

confidence: 99%

Atypical fibroxanthoma of the skin with metastasis

Helwig

May

1986

Cancer

169

129

View full text Add to dashboard Cite

Cutaneous atypical fibroxanthoma (AFX) occurs in elderly persons as a small nodule or ulceronodule in actinically damaged skin of the head and neck area. The vast majority of AFX behave in a benign manner, and metastasis is rare. Eight examples of metastasizing AFX are reported. Factors that portend aggressive behavior and metastasis are vascular invasion, recurrence, deep tissue invasion, tumor necrosis and, possibly, defective or depressed host resistance. The metastasizing primary AFX were located on the head, and the metastasis involved the structures in the region of the parotid gland.Cancer 57:368-376, 1986.UTANEOUS ATYPlCAL FIBROXANTHOMA (AFX)C usually occurs in the elderly as a small nodule or ulceronodule in actinically damaged skin of the head and neck. Histologically, an anaplastic appearance with multiplicity of cell types, marked cytologic atypia, bizarre giant cells, and abundant mitotic activity are characteri~tic.l-~ Paradoxically, the clinical course of atypical fibroxanthoma is almost always benign. Recurrent tumors are mentioned in most recorded series,2-8 but reports of metastasizing AFX are a rarity.2,R-'0 Eight cases of metastasizing AFX were studied to ascertain histologic and clinical factors that might aid in differentiating the aggressive lesions from the usual AFX. Seven are initially reported, and one was recorded previously.9 Materials and MethodsReview of the material on file at the Armed Forces Institute of Pathology revealed eight cases of AFX with clinical and histologic evidence of metastasis. All lesions met the established histologic criteria for AFX and were of dermal origin.2 Lesions that appeared to arise in the subcutaneous tissue or in deeper tissues were excluded. The cases were contributed by civilian pathologists and by pathologists of the Veterans Administration and the Military Services. Follow-up questionnaires were sent to pathologists, clinicians, and patients.

show abstract

“…The so-called "atypical fibroxanthoma," for example, has been variously referred to as pseudosarcoma of the skin,' paradoxical fibrosarcoma,* pseudosarcomatous derma-t~f i b r o m a ,~ and pseudosarcomatous reticulohistiocytoma. 4 The term "atypical fibroxanthoma" was originally applied by Helwig' to describe a nodular ulcerative lesion usually occurring on areas of actinic-or radiation-affected skin. The tumors histologically demonstrate pleomorphic atypical cells of fibrohistiocytic origin arranged either in haphazard fashion or in a vague fascicular pattern.…”

Section: Discussionmentioning

confidence: 99%

Mohs Surgery Report: Spindle Cell Fibrohistiocytic Tumors: Classification and Pathophysiology

Dzubow

1988

The Journal of Dermatologic Surgery and Oncology

View full text Add to dashboard Cite

Four patients with spindle cell cutaneous fibrohistiocytic neoplasms are presented. A classification scheme for this group of tumors is discussed along with the histologic and immunohistochemical criteria needed to establish the diagnosis. Cutaneous malignant fibrous histiocytoma (atypical fibroxanthoma) may behave biologically as a neoplastic rather than reactive mesenchymal tumor with definite invasive and metastatic potential.

show abstract

Pseudosarcomatous Reticulohistiocytoma

Cited by 32 publications

References 5 publications

Pseudosarcomatous dermatofibroma

Pseudosarcomatous dermatofibroma

Atypical fibroxanthoma of the skin with metastasis

Mohs Surgery Report: Spindle Cell Fibrohistiocytic Tumors: Classification and Pathophysiology

Contact Info

Product

Resources

About