Pseudoternary phase diagrams used in emulsion preparation

Jhawat, Vikas; Monika, Gulia; Sharma, Anil K.

doi:10.1016/b978-0-12-821748-1.00011-7

Cited by 7 publications

(2 citation statements)

References 37 publications

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“…For each phase diagram, Smix and oil were fully blended in various weight ratios ranging from 9:1 to 1:9 (i.e., 9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, and 1:9). Slow aqueous phase titration was used to create pseudo-ternary phase diagrams (14)(15)(16).…”

Section: Construction Of Pseudo-ternary Phase Diagrammentioning

confidence: 99%

Optimization and Evaluation of Anti-Inflammatory Herbal Emulgel loaded with Vitex Negundo for Enhanced Permeation

Keerthana¹,

Dubey²,

Mahadev³

et al. 2023

IJAM

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The use of conventional drugs for the treatment of pain and inflammation has largely resulted in various side effects. These challenges have triggered the search for alternative therapy such as herbal medication that may serve as a safe, effective, and alternate treatment approach to managing pain and inflammation. Vitex negundo, a potential lipophilic molecule, possesses limited solubility and permeability. Emulgels are either water-in-oil or oil-in-water type emulsions, mixed with a gelling agent to form a gel for the delivery of lipophilic active ingredients. Therefore the current study is undertaken for the effective delivery of vitex negundo locally in the form of oil-in-water emulgel for improving solubility and permeability. The emulgel was formulated from carbopol 934 with vitex negundo in mineral oil emulsion using tween 80 (surfactant), and triethanolamine (co-surfactant). The formulations were optimized using the design of experiment software. The optimized emulgel formulation containing Smix (tween 80 and triethanolamine) ratio of 61.90, mineral oil 50.58%, and carbopol 934 3% showed a pH of 6.5±0.3, a viscosity of 17793 – 939 cps, and spreadability of 7.07 g.cm/s. Data from in-vitro and ex-vivo diffusion studies demonstrated improved permeability properties. The stability of the optimized emulgel formulation was additionally examined at ambient temperature for 28 days. The emulgel remained stable for 28 days. Based on the overall results we can conclude that emulgel can be a promising and suitable formulation for the application of vitex negundo.

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Section: Construction Of Pseudo-ternary Phase Diagrammentioning

confidence: 99%

Optimization and Evaluation of Anti-Inflammatory Herbal Emulgel loaded with Vitex Negundo for Enhanced Permeation

Keerthana¹,

Dubey²,

Mahadev³

et al. 2023

IJAM

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“…Construction of pseudoternary phase-diagrams is a critical step to evaluate the effect of different formulation components on the stability and in-vitro performance of a lipid-based nanocarrier (Jhawat et al 2021. By constructing pseudoternary phase diagrams containing OO, water and surfactant mixture (S80:T80) at different ratios (presented in Fig 1A and 1B), it was found that the maximum NE zone was achieved at an S mix ratio of 2:1 In this study, water-in-oil NEs of CHG were prepared using HSH, followed by ultrasonication.…”

Section: Synthesis and Optimization Of Chg-nesmentioning

confidence: 99%

Nanoemulsions for enhanced skin permeation and controlled delivery of chlorohexidine digluconate

Kakadia

Conway

2022

Journal of Microencapsulation

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Chlorhexidine digluconate (CHG) is a widely used antiseptic for skin disinfection, as it exhibits poor skin permeability. Therefore, aim of the present study was preparation and evaluation of CHG nanoemulsions (NEs) using high-speed homogenization (HSH) combined with ultra-probe sonication to improve skin permeability. CHG-NEs were prepared using eucalyptus oil (EO) and olive oil (OO), with a surfactant-to-cosurfactant ratio of 2:1. Optimized NEs had a mean droplet diameter of 257.5 ± 12.4 nm and PDI of 0.56 ± 0.13. In In vitro permeation studies EO based NEs delivered more CHC into the skin, 6.15 ± 0.12 µg/mg compared to 3.01 ± 0.02 µg/mg for a control solution. Additionally NEs were incorporated into an in situ forming dressing and results showed controlled delivery of CHG within skin. Together, these findings bring new possibilities for topical antimicrobial treatment and prophylactic strategies in wound management.

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Enhancing the oral bioavailability of fisetin: polysaccharide-based self nano-emulsifying spheroids for colon-targeted delivery

Gunjal,

Vishwas,

Kumar

et al. 2024

Drug Deliv. and Transl. Res.

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Pseudoternary phase diagrams used in emulsion preparation

Cited by 7 publications

References 37 publications

Optimization and Evaluation of Anti-Inflammatory Herbal Emulgel loaded with Vitex Negundo for Enhanced Permeation

Optimization and Evaluation of Anti-Inflammatory Herbal Emulgel loaded with Vitex Negundo for Enhanced Permeation

Nanoemulsions for enhanced skin permeation and controlled delivery of chlorohexidine digluconate

Enhancing the oral bioavailability of fisetin: polysaccharide-based self nano-emulsifying spheroids for colon-targeted delivery

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