Pseudotumor cerebri from sinus venous thrombosis, associated with polycystic ovary syndrome and hereditary hypercoagulability

Finsterer, Josef; Kuntscher, Dagmar; Brunner, Simon; Krugluger, Walter

doi:10.1080/09513590701237290

Cited by 18 publications

(9 citation statements)

References 23 publications

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“…However, this theory is contradicted by reports of PTC occurrence in males or in females with Turner's syndrome [7,8]. Less popular theories talk about disturbances in the hypothalamic-hypophyseal-ovarian axis in response to stressful triggers, an allergic Jarisch-Herxheimer-type reaction to some undetermined infectious or noninfectious stimuli or theories that incriminate thrombophilia and/or hypofibrinolysis that lead to microthrombi in the choroid plexus leading to decreased drainage of the cerebrospinal fluid (CSF) and increased intracranial pressure [9][10][11]. The last theory seems to confuse intracranial hypertension due to increased CSF pressure with increased intracranial pres- sure due to increased volume of brain tissue.…”

Section: Discussionmentioning

confidence: 72%

Pseudotumor Cerebri: Categorical Disease or Spectrum of Disease

Walid¹

2011

J Neurol Res

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Section: Discussionmentioning

confidence: 72%

Pseudotumor Cerebri: Categorical Disease or Spectrum of Disease

Walid¹

2011

J Neurol Res

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“…In the literature, 23 we found association of pseudotumor cerebri from sinus venous thrombosis with polycystic ovary syndrome and hereditary hyper coagulability.…”

Section: Discussionmentioning

confidence: 95%

Pseudotumor cerebri in pediatric age: role of obesity in the management of neurological impairments

Marton

Feletti

Mazzucco

et al. 2008

Nutritional Neuroscience

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Pseudotumor cerebri occurs quite rarely in the pediatric population and its clinical features differ from adults in many ways. Intracranial hypertension with papilledema should obviously be treated promptly to avoid permanent visual damage, but various more or less invasive options have been proposed over the years, from bariatric surgery for obesity to optic nerve sheath fenestration. We report a prospective study on a group of 15 children, aged 3-16 years, with clinical and instrumental diagnosis of pseudotumor cerebri. All the patients were treated simply by external lumbar cerebrospinal fluid drainage with a mean volume of 10 ml/h for 3-5 days, with hypocaloric diet and with appropriate dosages of acetazolamide. All had immediate relief of headache, a considerable reduction in papilledema and marked improvement of both visual loss and cranial nerve palsies within 2 months. None of the patients relapsed during the follow-up period, ranging from 12-48 months.

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“…(3) We speculate that it is possible that metabolic changes of polycystic ovary syndrome can contribute to a prothrombotic state especially when the patient is treated with oral contraceptives (even for a short period of time). There are fewer similar cases published (3,4,5,6). Baillargeon also speculated that women with PCOS have an amplified cardiovascular risk; the long term use of oral contraceptives in such cases is contraindicated even if the patient is younger than 35 years or has no other risk factor (7).…”

Section: Discussionmentioning

confidence: 96%

Cerebral Venous Sinus Thrombosis in a Patientwith Polycystic Ovary Syndrome

Roman¹

2010

Acta Endo (Buc)

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Background. There are many systemic illnesses that constitute risk factors for cerebral vein thrombosis (CVT).The association between cerebral venous sinus thrombosis and polycystic ovary syndrome (PCOS) has been rarely reported in the literature. This report describes a case of cerebral venous sinus thrombosis following intake of contraceptive pill (cyproterone acetate 2mg + etinil-estradiol 35 micrograms), for dysfunctional uterine bleeding secondary polycystic ovary syndrome in young women.Case report. We reported a 22-year-old women presented with severe headache associated with vomiting sudden onset; she had been taking contraceptive pills for the previous ten days. CVT was diagnosed with CT scan, MRI and MR venography. Laboratory investigations showed no evidence of inherited thrombophilia. The patient was treated with classic heparine, followed by acenocumarol with good clinical outcome.Conclusions. This case illustrates that patients with polycystic ovary syndrome may develop thrombosis, if the patient is treated with combined contraceptives, even for short period of time. The role of PCOS as independent prothrombotic factor and the risk associated with oral contraceptive as first line treatement in PCOS need to be further investigated.

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Pseudotumor cerebri from sinus venous thrombosis, associated with polycystic ovary syndrome and hereditary hypercoagulability

Abstract: For the first time we describe the association of pseudotumor cerebri, optic nerve demyelination, PCOS, other endocrinologic abnormalities, and thrombophilia due to a factor V and prothrombin mutation. A causal relationship between these abnormalities remains elusive.

Cited by 18 publications

References 23 publications

Pseudotumor Cerebri: Categorical Disease or Spectrum of Disease

Pseudotumor Cerebri: Categorical Disease or Spectrum of Disease

Pseudotumor cerebri in pediatric age: role of obesity in the management of neurological impairments

Cerebral Venous Sinus Thrombosis in a Patientwith Polycystic Ovary Syndrome

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