Pseudotumor Cerebri Induced by All-trans Retinoic Acid Treatment of Acute Promyelocytic Leukemia

Pseudotumor cerebri

“…Hemolytic anemia and aplastic anemia have also recently been noted to be associated with PTC in other studies [24,25]. Other recent reports have linked PTC to primary aldosteronism, thyreostimulin suppression hormonotherapy after thyroidectomy, Crohn's disease, Goldenhar's syndrome, treatment of spontaneous cerebrospinal fluid leaks, minocycline for acne vulgaris, all-trans retinoic acid for acute promyelocytic leukemia, and mesalazine for ulcerative colitis [26][27][28][29][30][31][32][33][34][35].…”

High Pseudotumor Cerebri Incidence in Tretinoin and Arsenic Treated Acute Promyelocytic Leukemia and the Role of Topiramate After Acetazolamide Failure

“…PTC secondary to ATRA administration for APL has been well described in the literature through case reports in both the pediatric and young adult populations [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] and, among adults, has been most often associated with obese women of childbearing age [34]. However, all patients described in this report were males with a wide age range and body mass indexes (BMIs) consistent with an overweight (BMI 25.0-29.9 kg/m 2 ) or obese (BMI Z30 kg/m 2 ) stature.…”

“…PTC following ATRA administration for APL has been well described [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. However, reports of PTC resulting specifically from dual differentiation therapy are currently lacking, and there is a paucity of evidence describing management of this condition specifically in patients with APL, where continuation of therapy is necessary for optimal clinical outcomes.…”

Pseudotumor Cerebri Caused by All-Trans-Retinoic Acid Treatment for Acute Promyelocytic Leukemia

“…2 Pseudotumor cerebri is a rare complication of ATRA treatment characterized by signs and symptoms of intracranial hypertension without evidence of infective or space-occupying lesions. 3 Previous studies showed that pseudotumor cerebri is a complication of ATRA therapy occurring predominantly in children and usually within 2 weeks of the initiation of treatment. 4 We report herein a case of pseudotumor cerebri in an adult with APL after long-term ATRA treatment.…”