Pseudotumor of the Mandible as First Presentation of Hemophilia in a 2-Year-Old Male: A Case Report and Review of Jaw Pseudotumors of Hemophilia

Abstract

Pseudotumor of hemophilia (PTH) is a rare complication seen in approximately 1-2%

Haemophilic pseudotumour in two parts of the maxilla: case report

“…4,13 The treatment plan is chosen on a case-by-case basis, and most physicians have accepted that replacement therapy that provides the coagulation factor is a fundamental component of treatment and another appropriate therapy with replacement therapy is effective. 9,23 In conclusion, our case of a patient with haemophilic pseudotumour required a differential diagnosis with post-operative maxillary cysts, ameloblastoma, odontogenic cysts and fibrous dysplasia which were relatively common diseases compared with haemophilic pseudotumours. Although the preliminary diagnosis of a haemophilic pseudotumour is usually assumed by the medical history of haemophilia, previous reports showed haemophilic pseudotumour could occur in a patient who has no medical history although low percentage.…”

“…In this report, we briefly summarized our case and the previous 24 studies, 1,[3][4][5][6][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] which included 32 cases, on haemophilic pseudotumours of the jaw. Table 1 shows the summary of studies conducted between 1968 and 2014, including the present case.…”

“…Haemophilic pseudotumours can be caused not only by traumatic falls and strikes but also by mumps, 12 incisional biopsies 16 and extractions. 17 On the basis of radiographs, a haemophilic pseudotumour could be often misdiagnosed as a benign myxoma, giant cell tumour, aneurysmal bone cyst, osteosarcoma, ameloblastoma or similar lesion 8,9 because this disease was not pathognomonic.…”

“…Numerous attempts have been made to treat a haemophilic pseudotumour of the jaw by using treatment modalities such as radiotherapy, 5,10,20,21 cryoprecipitation, 11 curettage, 3,12,17,26 enucleation, 14,23 replacement therapy, 1,3,4,9,15,19,22,25,26 immobilization, 19 ethanol embolization 24 and resection. 4,13 The treatment plan is chosen on a case-by-case basis, and most physicians have accepted that replacement therapy that provides the coagulation factor is a fundamental component of treatment and another appropriate therapy with replacement therapy is effective.…”

“…On the basis of radiographic findings, a haemophilic pseudotumour can be misdiagnosed as a giant cell tumour, aneurysmal bone cyst, osteosarcoma, ameloblastoma, myxoma or other lesion. 8,9 The aim of this report was to present a case of a haemophilic pseudotumour that occurred in two parts of the maxilla. An expansive and thinly corticated lesion with fluid attenuation at the left anterior maxilla mimicked a post-operative maxillary cyst, ameloblastoma or odontogenic cyst radiologically.…”